Mercurial > repos > dfornika > mob_suite
changeset 41:cd69d25ce451 draft
"planemo upload for repository https://github.com/phac-nml/mob-suite commit 96af868783fb62b932e49452133d3e1a8e1d181c-dirty"
| author | dfornika |
|---|---|
| date | Thu, 14 Nov 2019 00:43:21 +0000 |
| parents | 8ad65c3af781 |
| children | bcf6aa9dbc77 |
| files | 1.4/mob_recon.xml 1.4/mob_typer.xml README.md distance_matrix_phylip.py distance_matrix_phylip.xml mash_dist_from_mob_db.xml mob_hostrange.xml mob_recon.xml mob_suite_databases.loc.sample mob_typer.xml mob_typer_refseq_download.py mob_typer_refseq_download.xml test-data/contig_report.txt test-data/mash_dist_matrix.phy test-data/mash_dist_matrix.txt test-data/mash_dist_plasmid_38.tsv test-data/mob_hostrange_._refseqhostrange_phylostats.txt test-data/mob_hostrange_._refseqhostrange_report.txt test-data/plasmid_38.fasta test-data/plasmid_476.fasta test-data/plasmids.msh tool_data_table_conf.xml.sample workflows/AMRworkflow_STARAMR.ga |
| diffstat | 22 files changed, 528 insertions(+), 448 deletions(-) [+] |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/1.4/mob_recon.xml Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,127 @@ +<tool id="mob_recon" name="MOB-Recon" version="1.4.9.1+galaxy0"> + <description>Type contigs and extract plasmid sequences</description> + <requirements> + <requirement type="package" version="1.4.9.1">mob_suite</requirement> + </requirements> + <command detect_errors="exit_code"> + <![CDATA[ + #import re + #import os.path + + #set $named_input = re.sub(r'(\s|\(|\)|:|!)', '_', str($input.element_identifier)+".fasta") + ln -s "$input" $named_input && + + mob_recon --num_threads \${GALAXY_SLOTS:-4} --infile "${named_input}" + #if str($adv_param.unicycler_contigs) == "True": + --unicycler_contigs + #end if + #if str($adv_param.run_circlator) == "True": + --run_circlator + #end if + #if str($adv_param.min_length_condition.min_length_param) == "True": + --min_length ${adv_param.min_length_condition.min_length_value} + #end if + --run_typer --min_rep_evalue '${adv_param.min_rep_evalue}' + --min_rep_evalue '${adv_param.min_rep_evalue}' + --min_mob_evalue '${adv_param.min_mob_evalue}' + --min_con_evalue '${adv_param.min_con_evalue}' + --min_rep_ident '${adv_param.min_rep_ident}' + --min_mob_ident '${adv_param.min_mob_ident}' + --min_con_ident '${adv_param.min_con_ident}' + --min_rpp_ident '${adv_param.min_rpp_ident}' + --outdir '.' && + mkdir ./sequences && (cp plasmid*.fasta chromosome.fasta ./sequences 2> /dev/null || true) + ]]> + </command> + <inputs> + <param name="input" type="data" format="fasta" label="Input" help="FASTA file with contig(s)"/> + <section name="adv_param" title="Advanced parameters" expanded="False"> + <param name="unicycler_contigs" label="Check for circularity flag generated by unicycler in contigs fasta headers" type="select" value="True"> + <option value="True">Yes</option> + <option value="False">No</option> + </param> + <param name="run_circlator" label="Run circlator minums2 pipeline to check for circular contigs" type="select" value="True"> + <option value="True">Yes</option> + <option value="False">No</option> + </param> + <conditional name="min_length_condition"> + <param name="min_length_param" label="Minimum length of contigs to process" type="select" value="False"> + <option value="False">No</option> + <option value="True">Yes</option> + </param> + <when value="True"> + <param name="min_length_value" type="integer" value="500" min="50"/> + </when> + <when value="False"/> + </conditional> + <param name="min_rep_evalue" label="Minimum evalue threshold for replicon blastn" type="float" min="0.00001" max="1" value="0.00001"/> + <param name="min_mob_evalue" label="Minimum evalue threshold for relaxase tblastn" type="float" min="0.00001" max="1" value="0.00001"/> + <param name="min_con_evalue" label="Minimum evalue threshold for contig blastn" type="float" min="0.00001" max="1" value="0.00001"/> + <param name="min_rpp_evalue" label="Minimum evalue threshold for repetitve elements blastn" type="float" min="0.00001" max="1" value="0.00001"/> + <param name="min_rep_ident" label="Minimum sequence identity for replicons" type="integer" min="0" max="100" value="80"/> + <param name="min_mob_ident" label="Minimum sequence identity for relaxases" type="integer" min="0" max="100" value="80"/> + <param name="min_con_ident" label="Minimum sequence identity for contigs" type="integer" min="0" max="100" value="80"/> + <param name="min_rpp_ident" label="Minimum sequence identity for repetitive elements" type="integer" min="0" max="100" value="80"/> + </section> + </inputs> + <outputs> + <data name="outfile1" format="tabular" from_work_dir="contig_report.txt" label="${tool.name} on ${on_string}: Overall contig MOB-recon report"/> + <data name="outfile2" format="tabular" from_work_dir="repetitive_blast_report.txt" label="${tool.name} on ${on_string}: Repetitive elements BLAST report"/> + <data name="outfile3" format="tabular" from_work_dir="mobtyper_aggregate_report.txt" label="${tool.name} on ${on_string}: Aggregate MOB-typer report for all contigs"/> + <collection name="seqhits" type="list" label="${tool.name} on ${on_string}: Extracted sequences (plasmids,chromosome(s))"> + <discover_datasets pattern="__name_and_ext__" directory="sequences" /> + </collection> + </outputs> + <tests> + <test> + <param name="input" value="plasmid_476.fasta" ftype="fasta"/> + <section name="adv_param"> + <param name="unicycler_contigs" value="True"/> + <param name="run_circlator" value="True"/> + </section> + <output name="outfile1"> + <assert_contents> + <has_text text="NC_019097"/> + </assert_contents> + </output> + </test> + </tests> + <help> + +**Syntax** + +This tool reconstructs individual plasmid sequences from draft genome assemblies using the plasmid reference databases. + +For more information please visit https://github.com/phac-nml/mob-suite/. + +**Workflow** + +This preliminary \"Mobilome and Resistome Analysis Workflow\" linking mob_recon with staramr provides reports on mobilome and resistome for a given isolate given a draft genome assembly. The workflow is located in Shared Data --> Workflows --> Mobilome and Resistome Analysis Workflow (MOB-Recon and STARAMR). The workflow file can also be manually downloaded from https://raw.githubusercontent.com/phac-nml/galaxy_tools/master/tools/mob_suite/workflows/AMRworkflow_STARAMR.ga. + +----- + +**Input:** + +A FASTA file with a single or multiple contigs (e.g. a draft genome assembly): + + +**Output:** + +Tab-delimited report listing information for each input contig on its cluster number, possible replicon, relaxase, and repetitive elements types, etc. Refer to https://github.com/phac-nml/mob-suite#mob-recon-contig-report-format for the description of each column. + +Note: Plasmid sequences will not be output if none are found. Some plasmid could be intergrated into a chromosome. + + + </help> + <citations> + <citation type="bibtex"> + @misc{githubmob-suite, + author = {Robertson J, Nash J}, + title = {MOB-Suite: Software tools for clustering, reconstruction and typing of plasmids from draft assemblies.}, + publisher = {GitHub}, + journal = {GitHub repository}, + doi = {10.1099/mgen.0.000206}, + url = {https://github.com/phac-nml/mob-suite} + }</citation> + </citations> +</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/1.4/mob_typer.xml Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,81 @@ +<tool id="mob_typer" name="MOB-Typer" version="1.4.9.1+galaxy0"> + <description>Get the plasmid type and mobility given its sequence</description> + <requirements> + <requirement type="package" version="1.4.9.1">mob_suite</requirement> + </requirements> + <command detect_errors="exit_code"> + <![CDATA[ + ln -s "${input}" "${input.name}"; + mob_typer --num_threads \${GALAXY_SLOTS:-4} --infile "${input.name}" + --min_rep_evalue '$adv_param.min_rep_evalue_value' + --min_mob_evalue '$adv_param.min_mob_evalue_value' + --min_con_evalue '$adv_param.min_con_evalue_value' + --min_ori_evalue '$adv_param.min_ori_evalue_value' + --min_mpf_evalue '$adv_param.min_mpf_evalue' + --min_rep_ident '$adv_param.min_rep_ident' + --min_mob_ident '$adv_param.min_mob_ident' + --min_ori_ident '$adv_param.min_ori_ident' + --min_mpf_ident '$adv_param.min_mpf_ident' + --outdir '.'; + ]]> + </command> + <inputs> + <param name="input" type="data" format="fasta" label="Input" help="FASTA file with contig(s)"/> + <section name="adv_param" title="Advanced parameters" expanded="False"> + <param name="min_rep_evalue_value" type="float" value="0.00001" min="0.00001" max="1" label="Minimum evalue threshold for replicon blastn"/> + <param name="min_mob_evalue_value" type="float" value="0.00001" min="0.00001" max="1" label="Minimum evalue threshold for relaxase tblastn"/> + <param name="min_con_evalue_value" type="float" value="0.00001" min="0.00001" max="1" label="Minimum evalue threshold for contig blastn"/> + <param name="min_ori_evalue_value" type="float" value="0.00001" min="0.00001" max="1" label="Minimum evalue threshold for oriT elements blastn"/> + <param name="min_mpf_evalue" type="float" value="0.00001" min="0.00001" max="1" label="Minimum evalue threshold for mpf elements blastn"/> + <param name="min_rep_ident" label="Minimum sequence identity for replicons" type="integer" min="0" max="100" value="80"/> + <param name="min_mob_ident" label="Minimum sequence identity for relaxases" type="integer" min="0" max="100" value="80"/> + <param name="min_ori_ident" label="Minimum sequence identity for oriT elements" type="integer" min="0" max="100" value="90"/> + <param name="min_mpf_ident" label="Minimum sequence identity for mpf elements" type="integer" min="0" max="100" value="80"/> + </section> + </inputs> + <outputs> + <data name="outfile1" label="${tool.name}: Plasmid report on ${input.name}" format="tabular"> + <discover_datasets pattern=".+_report\.txt" visible="true" format="tabular" assign_primary_output="true"/> + </data> + </outputs> + <tests> + <test> + <param name="input" value="plasmid_476.fasta" ftype="fasta"/> + <assert_stdout> + <has_text text="JN253636"/> + </assert_stdout> + </test> + </tests> + <help> + +**Syntax** + +This tool provides *in-silico* predictions on plasmid typing including identification of replicon, relaxase and mate-pair formation protein types. MOB-typer also predicts mobility of a plasmid (Conjugative, Mobilizable, Non-mobilizable). Do not include multiple unrelated plasmids in the input FASTA file as they will be treated as a single plasmid. + +For more information please visit https://github.com/phac-nml/mob-suite/. + +----- + +**Input:** + +A FASTA file with a single or multiple contigs (e.g. plasmid.fasta): + + +**Output:** + +Tab-delimited report listing identified plasmid(s) and their predicted mobility. Refer to https://github.com/phac-nml/mob-suite#mob-typer-report-file-format for the description of each column. + + + </help> + <citations> + <citation type="bibtex"> + @misc{githubmob-suite, + author = {Robertson J, Nash J}, + title = {MOB-Suite: Software tools for clustering, reconstruction and typing of plasmids from draft assemblies.}, + publisher = {GitHub}, + journal = {GitHub repository}, + doi = {10.1099/mgen.0.000206}, + url = {https://github.com/phac-nml/mob-suite} + }</citation> + </citations> +</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/README.md Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,7 @@ +# MOB-suite: Software tools for clustering, reconstruction and typing of plasmids from draft assemblies + + +These are Galaxy wrappers for [MOB-Suite](https://github.com/phac-nml/mob-suite): a set of tools designed to be a modular set of tools for the typing and reconstruction of plasmid sequences from WGS assemblies. This wrapper allows to conveniently run all these tools on a Galaxy instance. Also coupling MOB-Suite tools with other AMR tools via workflows allows to obtain both mobilome and resistome valuable information. + + +For more information please refer to https://github.com/phac-nml/mob-suite
--- a/distance_matrix_phylip.py Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,69 +0,0 @@ -#!/usr/bin/env python - -import argparse -import sys -import csv -import numpy as np - -from Bio.Phylo.TreeConstruction import DistanceMatrix, DistanceTreeConstructor - - -def process_input_matrix(input_matrix): - """ Converts an array-of-arrays containting sample IDs and distances - into a BioPython DistanceMatrix object - """ - input_matrix.pop(0) - sample_names = [row[0] for row in input_matrix] - for row in input_matrix: - row.pop(0) - distance_matrix = [] - for input_matrix_row in input_matrix: - distance_matrix.append([float(i) for i in input_matrix_row]) - """ np.tril() converts a matrix like this: [[0 1 2] - [1 0 1] - [2 1 0]] - ...into this: [[0 0 0] - [1 0 0] - [2 1 0]] - ...but what we need to pass to DistanceMatrix() is this: [[0] - [1 0] - [2 1 0]] - ...so that's what the (somewhat cryptic) code below does. - """ - distance_matrix = np.tril(np.array(distance_matrix)) - num_rows = distance_matrix.shape[0] - """ masking the distance matrix with tril_indices gives a linearized - distance matrix [0 1 0 2 1 0] that we need to re-construct - into [[0], [1, 0], [2, 1, 0]] - """ - lower_triangular_idx_mask = np.tril_indices(num_rows) - linear_distance_matrix = distance_matrix[lower_triangular_idx_mask] - distance_matrix = [] - min = 0 - max = 1 - for i in range(num_rows): - distance_matrix.append(linear_distance_matrix[min:max].tolist()) - min = max - max = max + (i + 2) - - distance_matrix = DistanceMatrix(names=sample_names, matrix=distance_matrix) - - return distance_matrix - -def main(): - parser = argparse.ArgumentParser() - parser.add_argument("--input", dest="input", help="") - args = parser.parse_args() - - reader = csv.reader(open(args.input, "r"), delimiter="\t") - input_matrix = list(reader) - # Don't build a tree with fewer than 3 samples, just produce an empty file - if len(input_matrix) < 4: - print('();') - sys.exit(0) - distance_matrix = process_input_matrix(input_matrix) - distance_matrix.format_phylip(sys.stdout) - - -if __name__ == '__main__': - main()
--- a/distance_matrix_phylip.xml Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,29 +0,0 @@ -<tool id="distance_matrix_phylip" name="Distance Matrix to Phylip" version="0.1.0"> - <description></description> - <requirements> - <requirement type="package" version="1.73">biopython</requirement> - </requirements> - <command detect_errors="exit_code"> - <![CDATA[ - $__tool_directory__/distance_matrix_phylip.py - --input '${input}' - > '${output}' - ]]> - </command> - <inputs> - <param name="input" type="data" format="tabular" label="Input" help=""/> - </inputs> - <outputs> - <data name="output" format="phylip"/> - </outputs> - <tests> - <test> - <param name="input" value="mash_dist_matrix.txt"/> - <output name="output" file="mash_dist_matrix.phy"/> - </test> - </tests> - <help> - </help> - <citations> - </citations> -</tool>
--- a/mash_dist_from_mob_db.xml Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,59 +0,0 @@ -<tool id="mash_dist_from_mob_suite_db" name="mash dist" version="@TOOL_VERSION@+galaxy0"> - <description>determines how well query sequences are contained within a pool of sequences.</description> - <macros> - <import>macros.xml</import> - </macros> - <requirements> - <requirement type="package" version="@TOOL_VERSION@">mash</requirement> - </requirements> - <version_command>mash --version</version_command> - <command detect_errors="exit_code"><![CDATA[ - #set $query_name = $query.element_identifier - cp '$query' '$query_name' && - mash dist - '${reference}/ncbi_plasmid_full_seqs.msh' - '$query_name' - > '$output' - ]]></command> - <inputs> - <param name="reference" type="select"> - <options from_data_table="mob_suite_databases"> - <validator type="no_options" message="No MOB-suite databases are available." /> - </options> - </param> - <param name="query" type="data" format="fasta" label="Assembly" help="Assembly"/> - </inputs> - <outputs> - <data name="output" format="tabular" /> - </outputs> - <tests> - <test> - <param name="reference" value="plasmids.msh"/> - <param name="query" value="plasmid_38.fasta"/> - <output name="output" file="mash_dist_plasmid_38.tsv"/> - </test> - </tests> - <help><![CDATA[ -Description: - - Estimate the distance of each query sequence to the reference. - Both the reference and queries can be fasta or fastq, gzipped or not, - or Mash sketch files (.msh) with matching k-mer sizes. Query files can also - be files of file names (see -l). Whole files are compared by default (see -i). - The output fields are [reference-ID, query-ID, distance, p-value, shared-hashes]. - ]]></help> - <citations> - <citation type="bibtex"> -@article{ondov2016mash, - title={Mash: fast genome and metagenome distance estimation using MinHash}, - author={Ondov, Brian D and Treangen, Todd J and Melsted, P{\'a}ll and Mallonee, Adam B and Bergman, Nicholas H and Koren, Sergey and Phillippy, Adam M}, - journal={Genome biology}, - volume={17}, - number={1}, - pages={132}, - year={2016}, - publisher={BioMed Central} - } - </citation> - </citations> -</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/mob_hostrange.xml Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,89 @@ +<tool id="mob_hostrange" name="MOB-Hostrange" version="2.0.2+galaxy0"> + <description> + Provides information on plasmid reproductive host range and transfer rate using both sequencing + and experimental data from public databases (NCBI) and publications (PubMED). + </description> + <requirements> + <requirement type="package" version="2.0.2">mob_suite</requirement> + </requirements> + <command detect_errors="exit_code"> + <![CDATA[ + mob_hostrange + ${exact_match} + ${loose_match} + ${host_range_detailed} + #if str(${replicon_name}) != "" + --replicon_name '${replicon_name}' + #end if + #if str(${relaxase_name}) != "" + --relaxase_name '${relaxase_name}' + #end if + #if str(${relaxase_accession}) != "" + --relaxase_accession '${relaxase_accession}' + #end if + #if str(${cluster_id}) != "" + --cluster_id '${cluster_id}' + #end if + --inputseq "${inputseq}" + --outdir '.'; + ]]> + </command> + <inputs> + <param name="inputseq" type="data" format="fasta" label="Input" help="plasmid FASTA file"/> + <param name="exact_match" type="boolean" truevalue="--exact_match" falsevalue="" checked="false"/> + <param name="loose_match" type="boolean" truevalue="--loose_match" falsevalue="" checked="false"/> + <param name="host_range_detailed" type="boolean" truevalue="--host_range_detailed" falsevalue="" checked="false"/> + <param name="replicon_name" type="text" /> + <param name="relaxase_name" type="text" /> + <param name="relaxase_accession" type="text" /> + <param name="cluster_id" type="text" /> + </inputs> + <outputs> + <data name="hostrange_phylostats" label="${tool.name}: Phylostats report on ${input.name}" format="tabular"> + <discover_datasets pattern=".+hostrange_phylostats\.txt" visible="true" format="tabular" /> + </data> + <data name="hostrange_report" label="${tool.name}: Hostrange report on ${input.name}" format="tabular"> + <discover_datasets pattern=".+hostrange_report\.txt" visible="true" format="tabular" /> + </data> + </outputs> + <tests> + <test> + <param name="inputseq" value="plasmid_476.fasta" ftype="fasta"/> + <assert_stderr> + <has_text text="RefSeq Plasmid database found no hits"/> + </assert_stderr> + </test> + </tests> + <help> + +**Syntax** + +This tool provides information on plasmid reproductive host range and transfer rate using both sequencing and experimental data from public databases (NCBI) and publications (PubMED). The predicted host range represents a range of putative hosts where a given plasmid can stably replicate and be maintained by the host. The host range module makes no source attribution predictions of a plasmid. + +For more information please visit https://github.com/phac-nml/mob-suite/. + +----- + +**Input:** + +A FASTA file with a single or multiple contigs (e.g. plasmid.fasta): + + +**Output:** + +Tab-delimited reports listing predicted hostrange information. Refer to https://github.com/phac-nml/mob-suite#mob-hostrange-report-file-format for the description of each column. + + + </help> + <citations> + <citation type="bibtex"> + @misc{githubmob-suite, + author = {Robertson J, Nash J}, + title = {MOB-Suite: Software tools for clustering, reconstruction and typing of plasmids from draft assemblies.}, + publisher = {GitHub}, + journal = {GitHub repository}, + doi = {10.1099/mgen.0.000206}, + url = {https://github.com/phac-nml/mob-suite} + }</citation> + </citations> +</tool>
--- a/mob_recon.xml Tue Nov 05 16:46:20 2019 -0500 +++ b/mob_recon.xml Thu Nov 14 00:43:21 2019 +0000 @@ -1,7 +1,7 @@ -<tool id="mob_recon" name="MOB-Recon" version="2.0.1_galaxy0"> +<tool id="mob_recon" name="MOB-Recon" version="2.0.2+galaxy0"> <description>Type contigs and extract plasmid sequences</description> <requirements> - <requirement type="package" version="2.0.1">mob_suite</requirement> + <requirement type="package" version="2.0.2">mob_suite</requirement> </requirements> <command detect_errors="exit_code"> <![CDATA[ @@ -11,12 +11,10 @@ #set $named_input = re.sub(r'(\s|\(|\)|:|!)', '_', str($input.element_identifier)+".fasta") ln -s "$input" $named_input && - mob_recon - --num_threads \${GALAXY_SLOTS:-4} - --infile "${named_input}" + mob_recon --num_threads \${GALAXY_SLOTS:-4} --infile "${named_input}" #if str($adv_param.unicycler_contigs) == "True": --unicycler_contigs - #end if + #end if #if str($adv_param.run_circlator) == "True": --run_circlator #end if @@ -31,10 +29,8 @@ --min_mob_ident '${adv_param.min_mob_ident}' --min_con_ident '${adv_param.min_con_ident}' --min_rpp_ident '${adv_param.min_rpp_ident}' - --outdir '.' && - mkdir ./plasmids && - (cp plasmid*.fasta ./plasmids 2> /dev/null || true) && - tar -czf plasmids.tgz plasmids + --outdir 'outdir' && + mkdir ./outdir/plasmids && (mv outdir/plasmid*.fasta ./outdir/plasmids 2> /dev/null || true) ]]> </command> <inputs> @@ -69,10 +65,13 @@ </section> </inputs> <outputs> - <data name="contig_report" format="tabular" from_work_dir="contig_report.txt" label="${tool.name} on ${on_string}: Overall contig MOB-recon report"/> - <data name="repetitive_blast_report" format="tabular" from_work_dir="repetitive_blast_report.txt" label="${tool.name} on ${on_string}: Repetitive elements BLAST report"/> - <data name="chromosome" type="data" format="fasta" from_work_dir="chromosome.fasta" label="${tool.name} on ${on_string}: plasmids (zipped)"/> - <data name="plasmids_zipped" type="data" format="zip" from_work_dir="plasmids.tgz" label="${tool.name} on ${on_string}: plasmids (zipped)"/> + <data name="contig_report" format="tabular" from_work_dir="outdir/contig_report.txt" label="${tool.name} on ${on_string}: Overall contig MOB-recon report"/> + <data name="repetitive_blast_report" format="tabular" from_work_dir="outdir/repetitive_blast_report.txt" label="${tool.name} on ${on_string}: Repetitive elements BLAST report"/> + <data name="mobtyper_aggregate_report" format="tabular" from_work_dir="outdir/mobtyper_aggregate_report.txt" label="${tool.name} on ${on_string}: Aggregate MOB-typer report for all contigs"/> + <data name="chromosome" format="fasta" from_work_dir="outdir/chromosome.fasta" label="${tool.name} on ${on_string}: Chromosome"/> + <collection name="plasmids" type="list" label="${tool.name} on ${on_string}: Plasmids"> + <discover_datasets pattern="__name_and_ext__" directory="plasmids" /> + </collection> </outputs> <tests> <test> @@ -81,7 +80,7 @@ <param name="unicycler_contigs" value="True"/> <param name="run_circlator" value="True"/> </section> - <output name="outfile1"> + <output name="contig_report"> <assert_contents> <has_text text="NC_019097"/> </assert_contents> @@ -89,6 +88,7 @@ </test> </tests> <help> + **Syntax** This tool reconstructs individual plasmid sequences from draft genome assemblies using the plasmid reference databases. @@ -111,17 +111,18 @@ Tab-delimited report listing information for each input contig on its cluster number, possible replicon, relaxase, and repetitive elements types, etc. Refer to https://github.com/phac-nml/mob-suite#mob-recon-contig-report-format for the description of each column. Note: Plasmid sequences will not be output if none are found. Some plasmid could be intergrated into a chromosome. + + </help> <citations> <citation type="bibtex"> - @misc{githubmob-suite, - author = {Robertson J, Nash J}, - title = {MOB-Suite: Software tools for clustering, reconstruction and typing of plasmids from draft assemblies.}, - publisher = {GitHub}, - journal = {GitHub repository}, - doi = {10.1099/mgen.0.000206}, - url = {https://github.com/phac-nml/mob-suite} - } - </citation> + @misc{githubmob-suite, + author = {Robertson J, Nash J}, + title = {MOB-Suite: Software tools for clustering, reconstruction and typing of plasmids from draft assemblies.}, + publisher = {GitHub}, + journal = {GitHub repository}, + doi = {10.1099/mgen.0.000206}, + url = {https://github.com/phac-nml/mob-suite} + }</citation> </citations> </tool>
--- a/mob_typer.xml Tue Nov 05 16:46:20 2019 -0500 +++ b/mob_typer.xml Thu Nov 14 00:43:21 2019 +0000 @@ -1,7 +1,7 @@ -<tool id="mob_typer" name="MOB-Typer" version="2.0.1_galaxy0"> +<tool id="mob_typer" name="MOB-Typer" version="2.0.2+galaxy0"> <description>Get the plasmid type and mobility given its sequence</description> <requirements> - <requirement type="package" version="2.0.1">mob_suite</requirement> + <requirement type="package" version="2.0.2">mob_suite</requirement> </requirements> <command detect_errors="exit_code"> <![CDATA[ @@ -16,7 +16,7 @@ --min_mob_ident '$adv_param.min_mob_ident' --min_ori_ident '$adv_param.min_ori_ident' --min_mpf_ident '$adv_param.min_mpf_ident' - --outdir '.'; + --outdir 'outdir'; ]]> </command> <inputs> @@ -34,16 +34,16 @@ </section> </inputs> <outputs> - <data name="outfile1" label="${tool.name}: Plasmid report on ${input.name}" format="tabular"> - <discover_datasets pattern=".+_report\.txt" visible="true" format="tabular" assign_primary_output="true"/> + <data name="plasmid_report" label="${tool.name}: Plasmid report on ${input.name}" format="tabular"> + <discover_datasets directory="outdir" pattern=".+_report\.txt" visible="true" format="tabular" assign_primary_output="true"/> </data> </outputs> <tests> <test> <param name="input" value="plasmid_476.fasta" ftype="fasta"/> - <assert_stdout> - <has_text text="JN253636"/> - </assert_stdout> + <assert_stderr> + <has_text text="CP015838"/> + </assert_stderr> </test> </tests> <help>
--- a/mob_typer_refseq_download.py Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,143 +0,0 @@ -#!/bin/env python - -import argparse -import csv -import logging -import os -import re -import sys -import time -import urllib.request - -def parse_mash_result(path_to_mash_screen): - """ - Args: - path_to_mash_screen (str): Path to the mash screen report file. - Returns: - list(dict): Parsed mash screen report - For example: - [ - { "identity": 0.996805, - "shared_hashes": "935/1000", - "median_multiplicity": 38, - "p_value": 0.00, - "query_id": "GCF_001022155.1_ASM102215v1_genomic.fna.gz", - "query_comment": "[10 seqs] NZ_CP011612.1 Citrobacter freundii strain CAV1321, complete genome [...]" - }, - { "identity": 0.914483, - ... - } - ] - See mash docs for more info on mash screen report file: - https://mash.readthedocs.io/en/latest/tutorials.html#screening-a-read-set-for-containment-of-refseq-genomes - """ - - mash_screen_report_fields = { - 'identity': lambda x: float(x), - 'shared_hashes': lambda x: x, - 'median_multiplicity': lambda x: int(x), - 'p_value': lambda x: float(x), - 'query_id': lambda x: x, - 'query_comment': lambda x: x - } - - # Example mash screen report record (actual report has no header and is tab-delimited): - # identity shared_hashes median_multiplicity p_value query_id query_comment - # 0.998697 973/1000 71 0 GCF_000958965.1_matepair4_genomic.fna.gz [59 seqs] NZ_LAFU01000001.1 Klebsiella pneumoniae strain CDPH5262 contig000001, whole genome shotgun sequence [...] - - parsed_mash_result = [] - with open(path_to_mash_screen) as mashfile: - reader = csv.DictReader(mashfile, delimiter='\t', fieldnames=list(mash_screen_report_fields)) - mash_record = {} - for row in reader: - for field_name, parse in mash_screen_report_fields.items(): - mash_record[field_name] = parse(row[field_name]) - parsed_mash_result.append(mash_record.copy()) - return parsed_mash_result - -def mash_query_id_to_ncbi_ftp_path(query_id): - """ - Args: - query_id (str): Mash query ID (column 5 of mash screen report) - Returns: - list: Directory names used to locate reference genome - on ftp://ftp.ncbi.nlm.nih.gov/genomes/all/ - For example: - "GCF/001/022/155" - """ - prefix = query_id.split('_')[0] - digits = query_id.split('_')[1].split('.')[0] - path_list = [prefix] + [digits[i:i+3] for i in range(0, len(digits), 3)] - - return "/".join(path_list) - -def main(args): - logging.basicConfig() - log = logging.getLogger('mash_screen_refseq_download') - log.setLevel(logging.INFO) - - mash_results = parse_mash_result(args.input_file) - - for mash_result in mash_results: - url = None - query_id = mash_result['query_id'] - if re.match("^ref\|", query_id): - accession = re.search('ref\|(.*)\|', mash_result['query_id']).group(1) - url = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?" + \ - "&".join([ - "db=nucleotide", - "id=" + accession, - "rettype=fasta", - ]) - # NCBI API is rate-limited to 3 requests per second, so pause between requests - time.sleep(1) - try: - urllib.request.urlretrieve(url, accession + ".fasta") - log.info("Downloaded: " + url) - except urllib.error.HTTPError as e: - log.error("Download Failed: " + str(e)) - - elif re.match("^GCF", query_id): - ncbi_ftp_path = mash_query_id_to_ncbi_ftp_path(query_id) - assembly = query_id[:query_id.find("_genomic.fna.gz")] - ncbi_ftp_server_base = "ftp://ftp.ncbi.nlm.nih.gov" - url = "/".join([ - ncbi_ftp_server_base, "genomes", "all", - ncbi_ftp_path, - assembly, - query_id - ]) - # NCBI API is rate-limited to 3 requests per second, so pause between requests - time.sleep(1) - try: - urllib.request.urlretrieve(url, query_id) - log.info("Downloaded: " + url) - except urllib.error.HTTPError as e: - log.error("Download Failed: " + str(e)) - - if args.download_assembly_stats: - assembly_stat_url = "/".join([ - ncbi_ftp_server_base, "genomes", "all", - ncbi_ftp_path, - assembly, - assembly + "_assembly_stats.txt" - ]) - try: - urllib.request.urlretrieve(assembly_stat_url, assembly + "_assembly_stats.txt") - log.info("Downloaded: " + assembly_stat_url) - except urllib.error.HTTPError as e: - log.error("Download Failed: " + str(e)) - else: - log.error("query ID \"" + mash_result['query_id'] + "\" not recognized.") - - -if __name__ == '__main__': - script_name = os.path.basename(os.path.realpath(sys.argv[0])) - parser = argparse.ArgumentParser(prog=script_name, description='') - parser.add_argument("-i", "--input", dest="input_file", - help="Mash screen report file", required=True) - parser.add_argument("-a", "--assembly_stats", dest="download_assembly_stats", action='store_true', - help="For genome files, also download assembly_stats.txt file,", required=False) - - args = parser.parse_args() - main(args)
--- a/mob_typer_refseq_download.xml Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,37 +0,0 @@ -<tool id="mob_typer_refseq_download" name="MOB-Typer RefSeq download" version="0.1.0"> - <description>Parses MOB-Typer report and downloads reference files from refseq.</description> - <requirements> - <requirement type="package" version="11.0">ncbi-acc-download</requirement> - </requirements> - <command detect_errors="exit_code"><![CDATA[ - '$__tool_directory__/mob_typer_refseq_download.py' - -i $input - -o outdir - ]]></command> - <inputs> - <param name="input" format="tabular" type="data" /> - </inputs> - <outputs> - <collection name="downloaded_references" type="list"> - <discover_datasets pattern="__name_and_ext__" directory="outdir" /> - </collection> - </outputs> - <tests> - <test> - <param name="input" value="input/mash_screen_genome_single.tabular" /> - <output_collection name="downloaded_references" type="list"> - <element name="GCF_001601135.1_ASM160113v1_genomic" file="output/GCF_001601135.1_ASM160113v1_genomic.fna.gz" /> - </output_collection> - </test> - <test> - <param name="input" value="input/mash_screen_plasmid_single.tabular" /> - <output_collection name="output" type="list" > - <element name="NZ_CP019139.1" file="output/NZ_CP019139.1.fasta" /> - </output_collection> - </test> - </tests> - <help><![CDATA[ - ]]></help> - <citations> - </citations> -</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/contig_report.txt Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,2 @@ +file_id cluster_id contig_id contig_length circularity_status rep_type rep_type_accession relaxase_type relaxase_type_accession mash_nearest_neighbor mash_neighbor_distance repetitive_dna_id match_type score contig_match_start contig_match_end +plasmid_476.fasta 476 plasmid_476.fasta|SRR3703080_illumina_unicycler.fasta|8|length=91194|depth=3.25x 91194 Incomplete IncI1 000145__HE610900_00001 MOBP NC_019097 CP016520 0.000508006
--- a/test-data/mash_dist_matrix.phy Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,9 +0,0 @@ - 8 -A 0.0000 0.0135 0.0119 0.0391 0.0439 0.0111 0.0029 0.0000 -B 0.0135 0.0000 0.0070 0.0348 0.0563 0.0081 0.0152 0.0136 -C 0.0119 0.0070 0.0000 0.0318 0.0591 0.0013 0.0149 0.0119 -D 0.0391 0.0348 0.0318 0.0000 0.0550 0.0307 0.0407 0.0392 -E 0.0439 0.0563 0.0591 0.0550 0.0000 0.0574 0.0384 0.0441 -F 0.0111 0.0081 0.0013 0.0307 0.0574 0.0000 0.0140 0.0111 -G 0.0029 0.0152 0.0149 0.0407 0.0384 0.0140 0.0000 0.0030 -H 0.0000 0.0136 0.0119 0.0392 0.0441 0.0111 0.0030 0.0000
--- a/test-data/mash_dist_matrix.txt Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,9 +0,0 @@ -#query A B C D E F G H -A 0 0.0135016 0.0119383 0.0391011 0.0439391 0.0110882 0.00294054 2.38274E-05 -B 0.0135016 0 0.00698112 0.0348125 0.0563082 0.00808024 0.0152404 0.0135508 -C 0.0119383 0.00698112 0 0.0317837 0.0590885 0.00134007 0.014871 0.0119383 -D 0.0391011 0.0348125 0.0317837 0 0.0549966 0.030677 0.040724 0.0392331 -E 0.0439391 0.0563082 0.0590885 0.0549966 0 0.0574401 0.0384495 0.0440934 -F 0.0110882 0.00808024 0.00134007 0.030677 0.0574401 0 0.0139988 0.0111321 -G 0.00294054 0.0152404 0.014871 0.040724 0.0384495 0.0139988 0 0.00296902 -H 2.38274E-05 0.0135508 0.0119383 0.0392331 0.0440934 0.0111321 0.00296902 0
--- a/test-data/mash_dist_plasmid_38.tsv Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,49 +0,0 @@ -pBC13Kox003_2|10 plasmid_38.fasta 0.0623675 0 156/1000 -pBC15Kox001|17 plasmid_38.fasta 0.0730018 0 121/1000 -pBC15Ror002|11 plasmid_38.fasta 0.0848014 0 92/1000 -pBC15Rpl001_1|4 plasmid_38.fasta 0.132399 1.66543e-211 32/1000 -pBC15Rpl002|3 plasmid_38.fasta 0.126974 5.49483e-240 36/1000 -pBC15Rpl020|3 plasmid_38.fasta 0.126974 5.5993e-240 36/1000 -pBC16Cam003|37 plasmid_38.fasta 0.112887 0 49/1000 -pBC16Cfa001|5 plasmid_38.fasta 0.219531 2.12229e-30 5/1000 -pBC16Ecl021|6 plasmid_38.fasta 0.210897 1.1394e-36 6/1000 -pBC16Eco063|12 plasmid_38.fasta 0.0824989 0 97/1000 -pBC16Ehe001|9 plasmid_38.fasta 0.0637124 0 151/1000 -pBC16Ent002|10 plasmid_38.fasta 0.0623675 0 156/1000 -pBC16Kox022|30 plasmid_38.fasta 0.0693234 0 132/1000 -pBC16Kpn002_1|35 plasmid_38.fasta 0.0759181 0 113/1000 -pBC16Rpl007|34 plasmid_38.fasta 0.0693234 0 132/1000 -pBC16Rpl014|32 plasmid_38.fasta 0.0730018 0 121/1000 -pBC16Rsp003|21 plasmid_38.fasta 0.0690061 0 133/1000 -pBC16Rte001|36 plasmid_38.fasta 0.102268 0 62/1000 -pBC16Sma001|16 plasmid_38.fasta 0.0621044 0 157/1000 -pBC16Sma049|15 plasmid_38.fasta 0.0621044 0 157/1000 -pBC16Sma053|20 plasmid_38.fasta 0.0716227 0 125/1000 -pBC17Cfr022|23 plasmid_38.fasta 0.0709514 0 127/1000 -pBC17Ecl001|28 plasmid_38.fasta 0.0712856 0 126/1000 -pBC17Ecl003|29 plasmid_38.fasta 0.0744324 0 117/1000 -pBC17Ecl013|23 plasmid_38.fasta 0.0709514 0 127/1000 -pBC17Eko002|23 plasmid_38.fasta 0.0709514 0 127/1000 -pBC17Kpn024|1 plasmid_38.fasta 1 1 0/1000 -pBC17Kpn045|7 plasmid_38.fasta 0.0608169 0 162/1000 -pBC17Kpn050|8 plasmid_38.fasta 0.0600659 0 165/1000 -pBC17Psp001|9 plasmid_38.fasta 0.0637124 0 151/1000 -pBC17Ror004|27 plasmid_38.fasta 0.0696435 0 131/1000 -pBC17Rpl001|33 plasmid_38.fasta 0.0709514 0 127/1000 -pBC17Rpl002|31 plasmid_38.fasta 0.0677629 0 137/1000 -pBC17Rpl006|27 plasmid_38.fasta 0.0696435 0 131/1000 -pBC17Sma026|15 plasmid_38.fasta 0.0621044 0 157/1000 -pBC18Cfr011|25 plasmid_38.fasta 0.0686914 0 134/1000 -pBC18Eas001|38 plasmid_38.fasta 0.0364545 0 303/1000 -pBC18Ecl022|13 plasmid_38.fasta 0.0642645 0 149/1000 -pBC18Ecl030|24 plasmid_38.fasta 0.0709514 0 127/1000 -pBC18Ecl032|14 plasmid_38.fasta 0.0677629 0 137/1000 -pBC18Ecl034|23 plasmid_38.fasta 0.0709514 0 127/1000 -pBC18Ecl035|18 plasmid_38.fasta 0.0730018 0 121/1000 -pBC18Eco209|26 plasmid_38.fasta 0.0674584 0 138/1000 -pBC18Eco240|22 plasmid_38.fasta 0.0702918 0 129/1000 -pBC18Kox006|18 plasmid_38.fasta 0.0730018 0 121/1000 -pBC18Kox008|19 plasmid_38.fasta 0.0730018 0 121/1000 -pBC18Kpn061|17 plasmid_38.fasta 0.0730018 0 121/1000 -pBC19Ecl005_2|22 plasmid_38.fasta 0.0709514 0 127/1000 -pWA18Eco007|2 plasmid_38.fasta 1 1 0/1000
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/mob_hostrange_._refseqhostrange_phylostats.txt Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,1 @@ +rank sci_name db_hits convergance_rank convergance_sci_name
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/mob_hostrange_._refseqhostrange_report.txt Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,2 @@ +filename query_replicons query_mob_cluster_ids query_relaxase_names query_relaxase_name_accs convergance_refseq_rank convergance_refseq_sci_name +- None None None None NA NA
--- a/test-data/plasmid_38.fasta Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,4 +0,0 @@ ->BC19A327A_unicycler.fasta.fasta|38_length=14959_depth=3.63x_circular=true -ATGAACCTCCAGCATGAGCGGATCGACGCCCTGTGCCAGCAACTCAAACTCGAACGGGTGGCAACGCATTACCCCGTCCTGGCGCAGCAGGCGGTGCGCGAGGACTTCAGCTTCACCGACTTCCTGGAACACCTGTTGCGGCATGAAGCGGGGTGTCGCCAGCAGCGCAGCCGCGAACTGCTGACGCGGATGGCTTGCTTCCCGGGCATCAAGACCCTGGAGGACTATGACTTCAGCTTCAACCCCGGCGTGCCCAAGGCACTGGTGCAGGAGCTGGGCAGTCTGGCGTTTGTCGAACGGGCCGAGAACGTGGTGCTGATCGGACCCTCTGGCATCGGCAAGACCCACCTCGCCATCGCCTTGGGTTACAAGGCCGCGCAAGCCGGGGTCAAGACACGCTTCATCACGGCAGCCGACCTGATGCTGCAACTGAGCACGGCGCAGCGACAAGGGCGGCTGAAGGAATACTTCAACCGCGCCATCCTCGGTCCACGGCTGCTGGTGATCGATGAGATCGGCTACCTGCCTTTCGGACGCGAGGAAGCGAACCTGTTCTTTCAGGTGGTGGCGAAGCGCTATGAGAAAGGGGCGATGATCCTGACCTCGAACCTGCCGTTCAGCCAGTGGGCCGACGCGTTTGCCGGCGATACCACCCTGACAGCCGCGATGCTGGATCGGCTGCTGCACCATGCCCATATCCTGACCCTGAGCGGCGAAAGCTACCGCTTGAAGGACAAGAGGAAGGCGGGAGTGGTCAGGAAAAATTCCAAACCCGAATGATCCAGGTGGGTCAGTATTACTTTGGTGATTCAGGGGTAAAGTGGGTCAGTTTTCAGTTGGTGTTGACACCGGCGTACCCTCGGTGCTATCTTCGCGCCCCAATAGTCGGGGCTTGGCCAGGACTTCCTGAGGCCGTCCGTAACGTGGATGCCGAGGTCAGGCGAGGTGGCCGACCCATGAACGCCGACCTGATTCGTTTTTCAATAGCGCTGGACGTTGTGGTGCCAGGGACTTACCAACCCGATGTGTGCCCATCCGGGGCAGTTACAGCCGTTACAGCCTCTGGAGAGGGAGCGGCTTGCCGCTCGGTGATAATCCCAGCTGTAGCGGCCTGATTACATCCGGCCGCTACACCTAGCTCCACCTTCAAACAAGGAATATCGTTGATGTCACTGTATCGCCGTCTAGTTCTGCTGTCTTGTCTCTCATGGCCGCTGGCTGGCTTTTCTGCCACCGCGCTGACCAACCTCGTCGCGGAACCATTCGCTAAACTCGAACAGGACTTTGGCGGCTCCATCGGTGTGTACGCGATGGATACCGGCTCAGGCGCAACTGTAAGTTACCGCGCTGAGGAGCGCTTCCCACTGTGCAGCTCATTCAAGGGCTTTCTTGCTGCCGCTGTGCTGGCTCGCAGCCAGCAGCAGGCCGGCTTGCTGGACACACCCATCCGTTACGGCAAAAATGCGCTGGTTCCGTGGTCACCCATCTCGGAAAAATATCTGACAACAGGCATGACGGTGGCGGAGCTGTCCGCGGCCGCCGTGCAATACAGTGATAACGCCGCCGCCAATTTGTTGCTGAAGGAGTTGGGCGGCCCGGCCGGGCTGACGGCCTTCATGCGCTCTATCGGCGATACCACGTTCCGTCTGGACCGCTGGGAGCTGGAGCTGAACTCCGCCATCCCAGGCGATGCGCGCGATACCTCATCGCCGCGCGCCGTGACGGAAAGCTTACAAAAACTGACACTGGGCTCTGCACTGGCTGCGCCGCAGCGGCAGCAGTTTGTTGATTGGCTAAAGGGAAACACGACCGGCAACCACCGCATCCGCGCGGCGGTGCCGGCAGACTGGGCAGTCGGAGACAAAACCGGAACCTGCGGAGTGTATGGCACGGCAAATGACTATGCCGTCGTCTGGCCCACTGGGCGCGCACCTATTGTGTTGGCCGTCTACACCCGGGCGCCTAACAAGGATGACAAGTACAGCGAGGCCGTCATCGCCGCTGCGGCTAGACTCGCGCTCGAGGGATTGGGCGTCAACGGGCAGTAAGGCTCTGAAAATCATCTATTGGCCCACCACCGCCGCCCTTGCGGGCGGCATGGATTACCAACCACTGTCACATTTAGGCTAGGAGTCTGCGCGGCAGAGCCGTGTGACCGGTTTTCTGTAGAGCACTGACGATGGCGGCGGCGCTCTCTGCAATTGGCAAGGCGTCGGCGCCAAGGATACCAATCTTGCGGCGCGCGGCGTGTTATGACGACTGGGGTGCATTTGAGCCGCCCCATTTAACCTTCGCCCTCACAGATACGCCATTCGCCTCAGATTTAGCGCCATGCAGACGAGCTTCCACTCGGCTTGCACCTTGTCCAGGCCCCTCATGCTGAACTGACGCAATCCCATCACCGCCTTGATCCAACCATTCGGAGCCTCCACGATCGACTTGCGCCGGCGGTAAGCTGCATCGCCTTGCTCCGTTTTCAATTTCGCCGCAATCGCCGCCGTATGCGGATGGGTCTTGGCATTGACCTTGGCATCTTCACGTCCCTCGCGGCCGAGGGCAACGATGACATCGCCGTGGTGATCGGCGACCTTTGCCAGAACAGCCTCACTACGGAATCCCGCATCCGCCAGCGTCTGGGCCGGCATTTCTCCGGTGTTGGCCTGAACTGCTGCCAGCATGCCCAGCAGCGCCTGACTGTCCGCGGCGCAGTTGGTCAACTCCGCCGCCACGATGATCTGGTGCTCGGCATCGACCGCTGTGTACCCGTTGTAGCTCTGCTCGGAGCCACCACCGGCGTGTTTCATGATCCGGCTGTCCGGATCGGTGAAGCTTTCCTGATCACGGTCATCCGGCACACCAAACTCGCGTTTGTACGAGCCACCGCCCTTGTCCGAGCCATCCGGATGGCGAGGCCGGCGGCCATCGTCTTCGCTGCGCCCCCGGGCCTGGTCCGCTTCACGCTGGCGCGCTTCCAGGCGCGCCTTTGCCGCCTGGATCGCCTCCAGGCGCTTCTCGCGGCGAGAAATCTCGGCAGGAATGTCCAGCTCCGGCTCGTTACGCTCCTGGTCGTCGGTAGCCTTGGCGCGATCAAGCAGCGCCTTGATCTCGCAATGCAATTCGTCCTCGGCCGGCTTCATGCGCTTATAGCTCATCGCCTTGTGGCGGCTGGCGTTGGCTTTTACCTTGGTGCCGTCGACCGCGATCGTGCCAAGCTTCACCAGCCCACATTCGCGCGCCAGTTGCACCACCTGAACGAACAAATTCTCAAGCTCGGTCAGGTGTAGGGCACGGAAGTCACTCAGCGTGCGGTGGGCCGGGAAGTTTCCAGCGGCCAGCACACGCAACGCGACATCCTCGTACAGCTTCCTGGCTAGTTTGCGCGAAGAGAAGACGCCGCTCGCGTAACCATAGATCAGCACTTTGACCATCATCGCCGGATGAAACGGCTGATTGCCCGGACCACCGCCGGCATACCGGGCGTGGAATGCGCTCAAGTCCAGCGTATCGACAGTCTCGCTGATGAAGTAGGCAAGATGCCCTTCAGGTAGCCACTCTCCCAGAGAAGGGGGCAGCAGATAGGATTGGTCGGGTCGGTAAGGAAGGTAACTGGCAGCCATCCCCGTATCGTCCTCGATCTTCCGCCGATTTGGCTTCTGCCGCGCAGGCTCCTAGGCCACCGTAGCTAAACATACGAGAAAAACCGCTTCTTGAGCGCTCTCTGAGACCACCTTGCCGACAACGCAGAAACGGTTGCGGAAAAATCGGCGTTTCCGGCGTACGCCACCCGACCTGGACGAACTATTGCGGACCTGGAACTGGAGTAGCGGAATTCCCCGGGGTTTCAGCGTCGCGCCACAGCGCCTCAGATAGATGCGGTAGCCTTTGGCGGGTCGTCATGCCGCGGACCACCCCCCCAAAAAATTCCACAATGCGGAATGGCGGAATTTTCTGGGGTTCCCGCTTACCCCCCCAGTAGAAGGTGAAGTCGATGGTTTTGCATTCTTATTTCTGTACTCTATCGATTCTTCAGTAGCAAACTGAACAAAGTCTCCGACAGAGAAGTTAGGACATTTTTTCTGTCTTTTGAAAAAATCATATTGAATAACAGCGGCTAAATAGCCATTACAAAAACCCCAAGCTCCTTTTTCTTTTATATCGTTTCGTGCACTATCACAATGACTACCCCATTCTGACATGGTAGGGTGCGCTGCATCAATATATTTACTGCCAGGGATATTAATAGGCATATCAAAAATATTATTTTCAGCATTAACGGAAGAAGATAAGCTGATTAAATACAGAGTAAAAACAGACGCAACAAGTGAAAGTCTCATTATAAAAACCTCTTATTCATCCCAAGTCTATAATATTTACTACGGCTAATATTTAAATTTACCCATGGTTTTAAACTTGCATCAGATGCAATAGATATTCGTCCCTTTGGGCGACCTCCTCCTCGGCTTTTTTTTCCTCTAACTGATTGAATCTCACTAGAATGAGTACGAGATACATAGGCACCAAATGTTTCCTCACTAAATTTTGACTTAGTCCATTTAGCAATGCTCTTGGCTATACCATTAACCTCATTTTCATCCAGAGGCGCTGCAAATTGCAGGTTATAAGCGTTGGCACGTTCGTAGCAGGCTCTTAACCACTGTTCATAATCAGGCCAGCCCTGACGAATGGCGCGATAAGCCCATTTACGGGTTTTATCGAACAGGGTGCAGTTACGGCCTAAACCGTAGTCGGGTAGGATTTCTTTGTCGTTCGCTGCACTCAGGTCAAGTGAGTCTGCTAACCAGTCGAGCGTGTAGAGTTCCGGTTGCCACACGGCAAGCTGCCAGTGGTCATGGTTCGGATTTTTGCAGATTAACCCTGAATAGCCAGTGTCAGCGTCCAGTTTTTTACACAGCGCACGCTCAACCGCTGCCGCATACTTCAGCGGCTTAATTTTTCCGTCAGGTGCCGTGCGCACCGCTGTTTTCAGCGCATACAGTAAGTGGGCATGTCCGTTTTCCGGATTCATGATGGTCAGCGTTGGCGCAGGTGCGTTCCGGTCGCTCCAGTCTATCGCCGCGCCGGGGCGGTCAACGTCAAAACCGAGCCAGAACATCGCGTGTGGCTGGTTGAACTGGATGTATTTCGCAAGAATGGCGCGCTCTTTCCCGGCAATGCGTACTCCGAACTGGAGTTCGTCGGTAAAATAGGGTTTGCGGGGAAGCCGCTCGTTAAAAAGGTCGAGTGCCTGGTTACTCAATCTCGCCTGCGCTTATGGCGGGCTGTTGTTTCGCACGGTTCATGTGCTAGTATCCTTCTTAGGTTTTGTGCCTGCGCCCTCGTTAATCATGTCCTTCCGCCAAGTCGAGCATGATTACGGGGGCGTCGTCTTTTCTGCCGCTTAACGTTACACACCCCGCCGTATTTTGTCACCTGTCACCGTCAGTTATTGCCTGAAGCAACAGACCATTACCTTCCGGGTAAAAAACGCGTACACTGGCAACACGTGCTATATACACGTGTAAAAATCAGGAGATCATCATGCCCGTATCAGCGATGCGCCATAAAAAAACCGTCAGTGTGACAATCGAGCCTGCGCTTTTGCATCAGGCCCGCGAAGCCGGGATTAATCTGTCTGCCACGCTCACCACCGCCCTGAAACATCAGATCCGCGAGTCAGAAGCGGAGCGCTGGAAACGCGCCAACCGCAAGGCAATCCAGGAGCTCAACCGTATTACGGACGAGCACGGCTTACTCTCTGACGATCACAGGACGTTCTGATGCAGTTCATGGTTTACCGCAATAACAGCAACAACCGGGCTTATCCCTATCTGCTCGATGTACAGAGCGATATTATCGACGAACTGAATACCCGCCTGGTGATCCCGCTGTTTCTGCTGGATGAAGTGAATGGACGGCCCGCCCGCCGCCTGACCCCGGTGCTGAATGTGGACGGTGAGGATTTTCTGGTCATGACACATGAAATGGCCAGCGTTCGCCAGTCACAGCTCGGGGAAGAGGTGGTGAGCGTCCGGGAGCACCGGCAGGCCATCAAGAATGCGCTGGATTTTCTGCTCGACGGTTTCTGAGTTTACCTTTCCATCCCGTGATCGTGTCCCCGGCTGCGTCCGGGGGCAAATGAGCGCGTTTTCTGTCGTTCCTGTTTCTGCGCCAGCTCCCTGTCCAGTCTGGCTACCTGCGCGTCAAGCGGCTGACGGCTTCGGTTAAGCTCATGACCTGCTGCCGCAAGCTCTCCACCTGCCCGCTCAAGTGCTGACACGCCTGGTCGCTGCGCATCAGCGCGGCGGAAGTAGTGGTGAACATGGTCTGCAAGCTGTCGTAACTGGCCTGCCATGCCTGCTGTCGTGTCTCGTAATCGTCCTGTAAGCGCTCTAACGCACTCAGCAGCAGTTTTTCGGTCTCGGTCATGGATTTGCTTGTCCTTATCGCTAAAAACGCCGTATGGCGCTTCTGTGGCAACTGACGGGGCTATTTCGCGGTGTAGGTCACGACCTGTTTGTCGTTTTTCGAGGTGTACAGCTCGACGCCCTTCGCGCTCTTCGGCAGCACCACGTAATACTTGTTCTTCCGGGTGTCGTCCGTGAGTATTTCCACCCCCGCCCCCGATTTCGCTTTCAGGTCGGTAAGCTGCTGGCTGTAGCTGTTCATCTCGTCCAGACGTGAGGCGATGAGTGTCCCCTGAAACCACAGTATCCCCGACAGAATACCGATCAGCAGCACACCACAAAACAATATCCATATCAGCGCGATCGTGACCGAGCGCCGCAGCAGGGTTGTCTGCCTGACGTTCTGTTCGTGGATAGCGTCGCTGATGCTCTTCCCGCTTGATTTCAAGGCCTCGCTGATGGATTGCTCGAGCTTCACAAACTCGCTCTTCACGCTCTCCCCTGTACGCTGTGCCTGCTGCTTCGAGGTCTCTTCGAAGGCTTTCGCTAAATCTAAAATCCCGCTCATATAACGCCCCTTTTAACCGGATATTTCGTCCACCGTCCGGGTCGGCAATGCTGAGACTGCTTTTCGTTTCCCGCACCACCGTCAGCCCGCCGTTTTCCAGCGCCCTGACCACATTCTCACGGTTGCGGATCATACCCTGTGCCACCATCGTTTCCAGCGAGTCCGTAATGGCCTGCGCCGCCTTCTGACGGTCGCCGGGAAGGTCATTGCCCGGTGTCAGGGTGCGTCGTCGGGCAGGATCATGAGGGTCATCGAGGTTCAAGCGGTCATTGGTCAGAGTCTGCCAGGCGTTGACCCTGGGACGATCAGCCCGGTCATAGTAGGGTTGCAGGCGTTTTCCGCTCTGCAATTCGATGTTCGGGAACACAAAATTCAGCTCCAGCCTGTCCTTGTCCCGGTGCTCCACCCACAGACAGGCGTACTGGTCGCCGTCCAGACCGGGCAACAGTGTCTGCTCAAACTCATCCATCAGACGCACTTTCTCATCGTCAGGGAGGTTTTGTTCCCGGAACGACAACACCCCGGAGGTATAGGCGCGGGCAAACTCACAACCATCAATCAGTTGCCTGACACGCTCAGGCTCACCGCGCAGTACCACCGCTTTATCCCGATCACGTTCTTTTCCCAGCAGGTAATCCACCGGGCCACTGCCTGAACCCGCACCGCGGCTATGAATCTTGACGATCACGCTGTGTCTCCAGAAGCTCAGATAACTGGCGATCAAGGCTGGTCAGTACCGCCAGAAGAGAAACCTGCTGATGGGCCGAAAGCGAATCCAGACCATGCAGCTTACGGGCTATCTGATTGAGGTTATTGCCGATGCCGGTCACCTGACGAAGCAGTGCCGGATCAACGTCAGGCACACGCCGGCGACGCAATACATGTTCACCCAGACCGAGCGAACGTAACCATTCAGCGAGATGAGCACGATCACAACGTGCCAGCAGTCGCTCATGTTCACTCTCAGTCAGGCGGATTTTTATCTCTTTCGTTCGCTTGTCCATGACACTCCGCTGAGAAAACTTTCGCACCCAGAGTGCGAATTTTCGCAGTGGATGCCAGGGGTTTCGGGGGGCGGCGAGCCCCCTGAACCAGTCACAGAAGGAACCCTCGTAGAGGGGACGCTGTGTGTACTGGCTTATAGTGATTGATAAGTATGTCAGATTCTGTGCTGGCTGCAAAAAAAAAAGCCTTCTCTGGAGAAGGCTGTTATCTGATATAGGTTGTTTTTAGTCTCACAGAGAACATCTAGTGGATTGTTCTTAGCTTTAGCGATATCAGTGATATGATCAGCATCAGCATCAGCATCAGCATCATATTAGTTGATTGTATTTATTCATCATGCTGGCCATTATATGCTTTGAGCACCGTAGAATGGCTCTTCCCGCAAGTCCGAAGAATAATTAGCGCATGTTCAATGAGTTCTTTACTTCGTTGAGGACTAAACCATTCACCATTAAATTTACCCCCATGGAAAAGATTATTTCTAATTCTACAAATAAGAGAAAAAACAAGCTCAGACTTATTTCTATGGTCAGGCAATACATTAGACCAACATAATAAACCATCTTTTAAAACTTGTTTTTTTGGTGGGTTGTTTATCAGGTATGATATTGACTCATTTAACTCTTTACTTGGACTTTCAATCAATGAAACGAATTCACCAGCATACTTATACCAATCAGCTTCTACTCTAGTATTTGTGCCCTTACGAAATCCGGTAACCTTAAGACAATATTCATAGCGAGCAAATTCACGAAAAAAGTTATATCCTAAATAATCTAGTTCTAATGTAGATTGCTTCATAAAAACCTCATAAATGAAAAAATATGTAATTTAATTTATATTACACTTTTCCATTACAATAGATTCCAACACAAGAAAAGCAGGGCGCTGGCCCGGGGCAGGGACATTTTCATAAACATAAGCATTAGGAATAACTTTACCAGTAGGGGGTTCTAAGCGGGAATCCCAGAAAATTCCGTCATTCCGTATGATGAAAATTCAGTCGACTCCTCGCTTGACGTGACGAGCGCCAAAAGCCTGCCGCATCTGCCTGGCGCGCTCGAGCTCATCGCCATGCAAATACATCGACGTCGTGGCGATCGACGCATGGCGTAGGTTGTCGCGCACCGCGGTGAGCTGAGCTCCCCGGGCCAACGCATGGCTGGCATGACTGTGACGCATCCAATGAGGCGTGGCACGGCGCAGCTTTTCGGCGGCGACCGGATGATCGGCCTCAATGGCCTCAGCGGCTTGCGTAAAGAATCTTCGCAACACGCACCAAAGGTGAGGGCCGGTGATGCCGGCATTACCGTCTTCCCCAAGACTGCCCACCAGGGGCGTTTTCGGATTCCACCGTTCCCGGCTGACTGGCAGTTGACGCTGTGCCAAGTATTGGTCCAGCGCCGTATACGCGAGCGGCGGCAAGGCCACCTTACCTGGTTTGCCACCTTTGCCAACCAAATGCAGCCAGTGGTCACCGTGCTCGTCGAGGCGGACATTACCCAGGACGGCGCCGACCAGTTCGCTAGCGCGCAGGCCCGTGGCATAGCCGAAGTCGAGCATGAAGCGCAGGCGTTGTGCTGCCGGCTCGGACCAGCCGTAGGACCATTCCAGGCCGTCTGCAATGGCGCGCAGCAGTAGCCATTCTCCCTCGGTAAAGCCTCGCGCCGTATCCAGTGCGGGCCGCAAGGCGTGACCGCGTACCTTGACGCCGGCGAAAGGGTTGGCCAGCACATAGCGCTGCTCGATGAGCCACCGGAACAGCGCCGAGAGCACCGTCAGCGCATACGCTGCCGAGCGTGCGGACAAGCCGCCCGAGAAGGGGCGCCATTCCACCGAATCGCGTGGTCGAGGTGGCCCCACCCAACGCTCGCGCGGGGTCGGGTGCCGGACAAAGGCCCGGTACGCGATTGCATCGTCCGTGGTCAGGGATGATAGCGCCCGTCCGCGTTCGACGATGGCCCACAGGATTAGCCGCGCAGCCTCCTTGCGATAGGCGCGCTGTGTGGCGACAGTCTCGTGCAGCGCCAGCCAGGCCTGCACGGCCTCGTAGTCGTTGGTCGCATTCAGCGTGCAAGCGTTGCGCGGGGCCCGGAAATTGCCCTGCGAGCCGTCGACTTCGTTCGGCAGACGCAACTGCTCCCACGGCACGATGCCGCTGGGCTGAATAATCGGGATCAGGGCCCGGGCGCGCTCGGTGAGCTGCGGATGTGCGGCAAAGAAAGCCTCGACCTGCCGGGCGCCTGTCATGCCGAGTCCCTCGATGGCTTTCCACCAGCCACGCCGGCGGGGAATGCGCACGGTCAGCGCCGAGAGGGTGTGGATACCGTACGCCTGCAGTGCCCTGACGGTCCTCGGAGACAGCCACTGGTCGATGCTGTCGCTGATCTGGGGCTTCGGCGCCGGCAGCGTGGGCAAGAGCCGGATCGCGCGTTCGACGGCACCCGCGCGCCCCTGTCGCTCTTCGGGGGCGTGCTGGAACACGTCGGCCAGATCCGGCCGGTGGCGGCTGTTGGCGAAAACGATGAGCTGGCGGCGGATATGCCCCAGCATCCCTCGCGCTGATTGACCGGCGGCCTTGCGTGCCGCCAGGTAGTGTTCAACGGCCGCGCGAGAGCTGAGTCCCGCGTACCAGCCGCGCAAGGCAGCCAGCGAATCCGCATCGGGAAAGCCGACTGGGGTAGAACTCGAAGCCGTAGTCTGGCCCGTTTTCATATGGACAGGTTGCGATTCGAAAAGCGAGTAACGCGATAATAACGATTATTTCAGTAGAATCGAAAATGCCCCATGTTTCTACGAAACCTCAAGATAGCAAGAACGGGCCATGAGCAAGAAGAACAAGCTACTCAGCGTCCTATCCGACGCCGAACAGGAGGCCTTGTATGGCCTGCCGGAGTTCGATGATGCGCAGCAGCTGGAATATCTGGCTGTGACAGAAACCGAGTTGGCGCTTGCCAACAGCCGGCCCAGTCTTCATGCCAAGGTCTATTGCCTCTTGCAGATCGGCTACTTCAAGGCCAAGCATGCCTTCTTCAGTTTCGACTGGGACGAAGTCGAGGACGATTGCGCTTTCGTGCTGAGCCGCTATTTCCACGGCGAGGTGTTCGAACCCAAGGCGATCACCAAGCATGAACGCTACACCCAGCGCGAGCAGATCGCCAAACTATTCGGCTACTGGCCGTGGTCGGCCGCCTTCCTGCCGCAGCTCGAGCAGCAGGCCGCACGGACCGTGCGGCGTGACGTAACGCCGGGGTTCGTCGCCGCCGAGCTGATCGTCTGGCTCAATGAGCACAAGATTATCCGGCCCGGCTATACGACCTTGCAAGAGTTGGTCAGCGAAACGCTATCCGCCGAGCGCCGGCGCCTGGGCAATCTGCTGGAGCAAGCGTTGGACGAATCTGCCAAGGCCGCGCTGAGCCAGCTTCTGGTCCGTGATGACACCCTGTCGCAACTGGCGGCGCTCAAGCAGGACGCCAAGAATTTCGGCTGGCGCCAGATGGTCCGCGAGCGCGAAAAGCGCGCCACGCTGGAGCCGCTGCACGCAATCGCCAAGACACTGCTGCCTAAACTCGACGTCTCGCAGCAGAACCTGCTGTACTACGCGAGCCTGGCAAACTTCTACACCGTCCACGACCTGCGCAATCTGAAGGCCGATCAGACCCAACTCTACCTGCTGTGCTATGCCTGGGTACGCTACCGGCAGCTCTCCGACAACCTGGTCGATGCGATGGCGTACCACATGAAGCAGTTGGAGGACGAAAGCAGCGCTGGTGCCAAACAATCCTTTGCCGACGAGCAGGTGCGCCGTCAGCAGGAAACGCCGCGGGTAGGCCGCCTGCTGTCACTCTACGTTGATGATAGCGTGGCCGATCCCACGCCCTTCGGCGAGGTGCGGCAGCGCGCCTACAAGATCATGCCTCGCGATACGCTGCAAACCACGGCGCAGCGTATGAGCGTGAAGCCGGCGAGCAAGCTGGCCTTGCAGTGGCAGGCGGTGGACGGGCTGGCCGACCGCATGCGCCGCCATCTTCGTCCACTGTACGTTGCGCTCGACCTCTCCGGCTCCAATCCAGACAGTCCATGGCTTGCCGCGCTGGCCTGGGCCAAAGGTGTTTTTGCCAAGCAGCAGCGGCTGTCGCAACGGCCACTCGACGAGTGGCCCGCGGCGACACTTCCGAAACGCTTGCGGCCGTACCTGCTGACCTTCGACGCCGACGGTAAACCAACCGGCCTGCACGCTGACCGCTACGAGTTCTGGCTGTACCGCCAGATCAGGAAGCGTCTCCAATCGGGTGAACTCTACCTCGACGACAGCCTGCAACACCGGCACTTCTCAGATGAACTGGTTGAGATGGACAGGAAGATCGATGTGCTCGCAAAAATGGAGATCCCCTTCCTGCAGCAACCCGTCCATGCCCAACTCGATGCGCTGACTGCCGAACTGCGCACGCAGTGGCTGGCGTTCAACCGCGAGCTGAAACAGGGCAAGCTGACGCACCTCGAATACAACAAGGACACGCAGAAACTGACCTGGCGCAAGCCCAAGAGCGAGAATGAGAAAGCGCGCGAAAAGGCATTCTACGAGAAGCTTCCGTTCTGCGACGTGGCCGACGTGTTTCGCTTCGTCAACGACGAGTGCAAGTTTCTGTCGGCGTTCACGCCCATGCAGCCGCGCTACGCGAAGAAGGTCGCCGACGCTGACAGCCTGATGGCGGTCATCATCGCGCAAGCGATGAACCACGGCAACCACGTCATGGCGCGCACCAGCGACATCCCGTACCACGTGCTGGATAGCGGCTACCAGCAGTACCTGCGCCAGGCAACGCTGCACGCGGCCAACGACTGCATCAGCAACGCCATCGCCACGCTACCGATCTTCCCATACTACTCGTTCGACCTCGAAACGCTGTACGGTGCCGTCGACGGGCAGAAATTCAGCGTCGAACGGCCGACCGTGAAGGCGCGCTATTCGCGCAAGTACTTCGGGCGCGGCAAGGGCGTGGTCGCCTACACGCTGCTGTGCAACCACATCCCGCTCAACGGCTACCTGATCGGCGCGCACGACTACGAGGCCCACCACGTGTTCGACATCTGGTATCGCAACACGTCGGACATCATGCCGACCGCGATCACCGGCGACATGCACAGCGTCAACAAGGCCAACTTCGCCATCCTGCATTGGTTTGGCCGGCGGTTCGAGCCGCGCTTCACCGACCTCAACGCGCAATTGAAAGAACTCTACTGCGCTGACGATCCAGCACAGTATCAGGCGTGCCTGATTCGGCCAGTCGGGAAAATCGACTGCGATCTCATCCATCGCGAGAAGCCGAACATCGACCGGATCGTCGCCACACTCGGGCTGAAGGAAATGACGCAGGGCACGCTGATCCGCAAGCTGTGCACCTACACCACGACGAACCCGACGCGGCGCGCGATCTTCGAGTTCGACAAGCTCATCCGCAGCATCTACACGCTTCGCTACCTGCGCGATCCGCAACTGGAACGCAACGTGCACCGCTCGCAAAATCGCCTCGAGTCCTACCATCAGCTACGCTCGGCCATTGCCCAGGTCGGCGGTAAGAAGGAACTGACCGGTCGCACCGACATTGAAATCGAGATCAGCAACCAGTGCGCACGGCTGATCGCCAACACGATCATTTTCTACAACTCGGCAATCTTGTCGCGGCTGGTGACCAAGTACGAGGCGGCCGGCAACAGCAAGGCGCTGGCACTCATCACAAAAATTTCGCCTGCGGCATGGCGGCACATCCTGCTCAACGGGCACTACACCTTTCAAAGCAGCGGCAAGACGATCGATCTCGATGCGATCGTCGCAGGCCTGGAACTGGAGTGACGGAATTTTCAGCGGTTCCGTGTTAGCAGCAGTGTAAAACTGACCCACCCCAGCGAAGTAAAACTGATCCACCTGGGCTAGTTTGGCGGCCTTTTCGAGGCCGTCGATGTTGACCCAGGAGCAAACCGTGGAAATCAGAGTTCTTGCCCGACAGGGCCACTCCATCCGGCACATCGCCCGCACGTTGGGGGTCTCGCGCAATACCGTGCGCCGCTACCTCCGCGATCCGTCGGTAGCGCGATACCAGCCCCGTGAACCACGCCCCACCAAACTGGGGCCATTTGAATCTTATCTGCGGCAACGGGTCGAGCAGGCCCACCCCATCTGGCTGCCTGCCACCGTCCTGAATCGGGAAATCCGCGCTCAAGGGTATGGCGGCGGTCTCTCGTTATTGCGCGCCTTCCTCGCCACGCTCAAGCCCGCCCGCCGCGAAGCAGGTCCGGCCGTCCGTTTCGAGACCGAGCCCGGACGGCAGTTGCAGGCTGATTTCGTGGTCTTGCGCCGGGCCAGATCCCCCATGTCGGCCTTCGTCGCCACGCTGGGATACAGCCGCATGACGTTTGTCACCTTCGTACCGGACGAATCCTTCGAGTCCGTGCGGGACTCCCTGTTGCTGGCTTTTGACTATCTGGGCGGTGTGCCCCGCGAGGTGTTGTTCGACAACATGAAGACCGTGGTGCTGGAACGCGATGCCTACGGTGACGGCAAGCACCGTTTTCACCCCGGCTTGCTTCAACTGGCCGATGACCTGGGGTTCCGGATCCGGCTGTGTCGCCCGTATCGGGCCCAGACCAAAGGCAAGGTCGAGCGCTTCAATCGCTACTTCCGCGAGAGCTTCTACAACCCGTTGCTGACCCGGATGAAGGGCACGGGGCTGCTGCTCGATTGTGCTGCTGCCAACCGACGCGTCCGTGACTGGTTGGCAGACGAGGCGAATGTGCGGGTCCACGCCACCCTGAACGAGCGCCCCATCGACCGTTGGCGGCAGGAGCGGGAACACCTGCAACCCTTGCCATCCCGTGTGCGGCGCGACGAGGCCCCCCTGCTGGATAACAGTCTCCGCCCGGTACCACTGGAATCTCTCCAGCACCCACTGTCTGTCTATGACGCAATTGGGGAGGCCTGCCG ->BC19A327A_unicycler.fasta.fasta|59_length=1339_depth=1.83x -AAACGGAATCTATGGTCACTCCCGTTTTTGCAACACCGATTTTGACGACAAGTTGGCTTGCTTGAATCTATCCGGCGTCTGAATGGGATTTTATTCCCGCGCCTTGATGAGTTCCGCGCCTGATGAACCTCCAGAAAATATACGGCTTCAATGAGCCTTTCCGTTTTACAGGTTCCTCAACAGGCCGGTGGGCCGTTAGTATCATCAATATCAGTATTCGCAAAACCAGATCAGTAATTCTTTAAACCGGTGTATTTCTGCCGTTATGCTACATAAGTTTGCTGTCGTGCCGTTAGGGCCCAGGCTATTCTGGCCAGCTTGTTTGCCAGAGCACAAGTGACGACAAAGTTGCTTTTCCGGCACAGTAAATCCCTGACCCAATCGGCCAATTTGCCAGACTGGTGTTCCAGTTTTTGTATGAATACCCTGGCACATTGAACCAACAAAGTTCGGATCTTTTTATTACCTCGCTTACTAATTCCCAGCAATGTCGTCCTACCTCCCGTGCTGTACTGCCGAGGTACAAGCCCTGTTGCCGCCGCAAAGTCACGGCTGCTGGCGTACTGCTTCCCGTCGCCAATCTCAGTTGAAATAGTACTCGCTGTCAGTGTTCCGACGCAGGGAATGCTCAGCAAGCGCTGTCCAACCTCATCTTCGTCCAACTTTCGTTTCAACTGGGATTCCAAATCTTTAATCTGCTCAACAAGATAGTGATAATGCTGTTGTAATTTCAGCAATAACTGGCTGAGGTAAAGAGGCAAACTATTATCCTCAAGAATGGTACTCAGTCGGCTAATAACGGCAGCTCCTCGGGGAACGCTAATGCCAAATTCCAGCAGAAAAGCATGCATTTGATTGGTTGTTTTTACCTTATCCTGAACCAGGGATTCACGGACACGATGCAGAGCCCGCATTGCCTGCTGAGATTCCGTTCTGGGCTGCACAAAACGCATAGACGGACGCGATGCAGCTTCACAAATAGCTTCGGCGTCGACAAAGTCGTTTTTATTGCTTTTAACGAACGGGCGGACAAATTGTGGTGATATCAGCTTTGGGGAATGCCCCAACTCTTCCAACTTGCGTGCCATAAAGTGAGAACCGCCACAGGCTTCCATTGCGATGGTTGTAGCGGGGCATGTCGCCAAAAATTCGATCAACTTTGGCCGGGTAAATTTTTTACGGTAAACAGCCTTCCCGCGACGATCCTGGCAATGAATATGGAAAGAGTTTTTACCCAGATCGATACCAATGAGCGCAATGTTTTCCATGATAGTTCTCCGAATGAAAGCCTGTCCTCAGCATAGTACCGGGAAGGAGGGAGTGACCATCTCATTAAATA
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/plasmid_476.fasta Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,2 @@ +>SRR3703080_illumina_unicycler.fasta|8|length=91194|depth=3.25x +AGGGCATCCGCCATGCTGCGGATTTCGGCCCGGGCTTCCCGGACCACCTCCCGCAGAACACCACGGTCAAACCACCGGCGGGGCGGTTCATCCGGTATACGCAGCACATCGCAGGCCAGCCCACTGGACAGGATATGCTCCACACACTCACTGACCAGATACATTTCCACCGCCGAAAAACGTGCTCCCCGGTTCAGGATGGCATCGAGCACCACGGGCAGGTTTTCGTCGTCTTCATCGAGCCAGCAGGGGTGATCGCTTTCCTTCACAACCAGGCGAAAGCGGCGCGTCTGGCGGGTCAGCAACGTCTGACCGGTTGTGGTCAGCGCCGCCCTGATACGCTGCGCATCTTCTGCCACCCGGCAACTGACACTGCGTACCGCATCGCGCACTGCATCAAGAACTGCCCTGATTTCGTCTTCGGTCAGCCATTCTCCGGCATACGGGAAAAACACCTGTGTTCCGTCTGCCGGAAGTACCGGCAGCGACTGCCACTGACTGCCAGACAGTACCAGTTCCGCCCCGGTTCCGGTCAGTTTCTGAATGGCGGAGGCCAGGAGCGGCGGCAGTACGCCGCCGTGACGGTTGATGAGTAACATCGCCAGCCGGGGCGCATCCAGCAGAACATAAATGCTGATCCAGCCCGGATACTTCGGGTTCCGCTGGTCAACATCCGTCTCTTCCGGCCAGCCCTGCGCCAGCAGCAGGTTGCGGGCGTGACGACAAATCAGTGCGTTCAGTGTTGTGTTTTCGTTCATGATTAATCGTTCTCCCTGAATCGCCGCCCGGAGGCGGCGATAACATCAGTCGTTTTCGTGTCTATTGTTTTTCAGCAGGGTGCGGGCCTGATTAATCACCGCCTGACGGCGGGTGACGCATTCCGGGACGGCGAGGCCATGATCCCGGGCGGCCCATTCACGTTTCCACAATGCCTGTTCAGCGGTCTGAATCAGGGACGCCAGCAGTTCAGCAGGGACGGTCACCTGGCGGTTTTCGCTCACGTTATTGATGATCTCCATCGCCACGCCGGAAGAAATACCGGATTCAGTCCGCTGGTCTTCCGGGATGTCCTCCAGGCGCGCCAGGACGGTTCTGATTTCATGATCGGACAGGGAAATATCCATTCCGTCAGCGAGGGCCTGAATCTCTTCCGGGGACCAGATAACCAGCATCAGCGGCATGTCTCCCGGATACTTTACTGCCAGCTCCCGGCATAGCGTTTCGCATGTTCCGTACATTCTCGTCTCCTTCTCAATCTTTAAAGCACGCTTCCAGTTCCAGAATTTCGGTATATGCCTCCATCAGGAGGCGGTTTGCGCGAAACAGCGTCTGACGCACCAGACGTTCCGGCAGGGTGTCGGCATTAAAGCTGTACCGCTGCTCCATCTCATTCATGGTTGTACGCAGGTCGCACATGGCATTGGCCACCTCCGCCACTTCGGCGCGCAGTTTTTCGTGTCCTGCATAGTTCATTTACGCAGCCTCCGGCATAAACCAGTCATCATTCGCGGCCCCCTGCTGCATGGCCCGTTGCACGGCGGCAAGGCGTTGCTGCCCGGCACGGTGATACTGCTCAAGCAGCTCGATACCGATATACCGGCGTCCGGACTGGAGGGCGGCGACGCAGGTTGAGCCGCTGCCTGCAAACGGGTCCAGCACAATTGCGTTCGGGTGTGTGAAGTTCTCAATCAGCGGTTGCAGGCTGGTAACGGGCTTTTCCGTCGGGTGATGGCGATTGCCCGAATATTTCCAGCCCAGCACGTCCGGCAGCGGGTTTTGTGGCAGACGTGGACGGCCTTTTGCCAGGATGTAGGCGCATTCGTGGCGATAGCCCACATATGCGGCCTTCGATGTGTAGTTTTTGGTGAAGACCAGGTGACCAACAACGCTGAATCCCGCATTTTTCCAGGCGGCCATAAAGCGATCGACGCGGTTCCAGCCGTAGAAGCTCACCATTAACGCGTCTTTTTTCAGCACGCGGAACATTTCATTACAGGCCGGTTGCAGCCACTCATCGGTTTTATCGCCGGCGATGGTGCGCCCGGAACGGTCACGGAAACCGACGAGATATGGCGGGTCGGTGAGGATGAAATCAATGGCGTTATCAGGAATACGGGCCATAACATCGATGCAGTTACCGAGGACAAAACGGGACATACGAAACTCCTTCTCTTACAGAGGGCACCGGGAGGGCACCCCTGTGGTGCCCGTTCCCCGCTGCCTGTGGGCTGTTCACCGCGTCCGGTAACGGGTCAGGCCGACCGTGGAATACCGCAGCCGTCGTCTTTCTGACGGCAAGGTTATGCCGCGAAAGCGGCTTGAAGGGCGTTCATCAGAAAAGGGCGACGGGCTGGCGTACACTGTCACCGACGCCAGCCGGGAGCGGTAAAAGCGCCCGTCCCGTGCCCGCCGGACGCGGGACACTGACCACAGGCAGCGTTTATGCCGCGCCGCGTCAGCCGGCGCAGTAAAAAGAGGAGCATGGCGACATCCTTTACCGGAAAAGAAACGGGCGGTTGCCCGCCCGTCTCCGTCATACTTCATCCACCGTAATGCGCCACCTTGTCGACTATCCACGCAGGTCCGGTGACTTCCGGCAGCTCATCATCATCTGTCGGGGAAGACCATTCCAGCTCCCCCCACAGCACATCAACAAGCTCTCCGCGCTCATACAACTGCCAGCCACAGAAATCACAGCCCTGTTCGGCATACCAGTGCTCCAGCGTGCAGCTGAAACGGCGGCTTAATTCTGCAATAACGTCGCTTTCCGGCTGACACCACGGCGTGTCGAAATCAACCTGAATGAAGTTGTCTCCCTGACTACTGATATTCAGGTCATACCCACAAGGCCACTTCACGCCATACCGTTCTGTATACCAGTGATATGCAGAAGGAACACCGTTCAGAACACCGCCGTTAAAGCCATTCACTTCAATATCCAGGCGGGTCGGCAAAACCGTCAGCAGGTCAAACGGCATGGTTTTTTCCGGCAGTACGTTGTCACACAGACGGTTCCACCACACCGATACATCCTCGTTACCCCAGATGTCACACCAGTCACCTCTTTTTGCGGTGAAATGCACAGTGATAGTTTCCCTGACATCATCCGGTAACTCTTCCCAGCGACGCTGTCCAGTACCGCTCTGCAGCCAGAGTTCATGCAGCATCAGGCAGTTTTGCTCATCCAGCAGTACACCGTTCTGCAGGTGTGTCAGCCAGCGGGTGAACGCGATATTTTCCGGTGATACAGCACCACGTCCGGCAGCCGTCACTCCGGGGCACTGCTCAGAGCGGATATTTTCAGTGATCTGCAGAAGTCCGGCACTTCCGGCCAGAAACAGCTGAATACCTTCATTTGTGGCGCGGCGATAAAGCGGTGTGACTGCACCGCTGGCCAGTCGTTTAATCTCAGCGATCTGTGCTGGTTCACCAGAAAAATACATACGATTCGAGCACCAGTTTGGCATGGGAATTCTCCTCTCACATGCGGCCTCCATCAGGCCGTGCCGCACCTGTAACCGGGCGACCGCATACGAATGCAGGTGCGGCCCCGAAGCCGCAGCGCGTGGAGGAGGAACGACGAAACGTGACCGGGTGAGGAGGCCGGCGACAGCGACACACTTGCATCGGATGCAGCCCGGTTAACGTGCCGGCACGGCCTGGGTAACCAGGTATTTTATTCACAGAACCGTGCGCAAAATGCTGTGGATAAGCTGGACACAGCAGTCCACAGCAGGCATACAGCCACACTCCCAGAGAATTGAGCGTTTTTTAGTCACAATAATGACATTTGACTGTGTGTGGATTCAGTTATTAGAATACTGTATATGCATACAGCAATAGAAAAGGGAGATGAGAACATGATCCGCATTGAAATTCTTTTCGACCGCCAGAGCACAAAAAACCTCAAATCAGGCACACTTCAGGCGCTACAGAATGAAATCGAACAACGTCTGAAACCACACTACCCGGAAATCTGGCTGCGTATAGACCAGGGCAGCGCCCCGTCTGTATCTGTCACAGGAGCCCGCAACGACAAGGATAAAGAACGTATCCTGTCTCTGCTGGAAGAAATCTGGCAGGACGACAGCTGGCTGCCTGCAGCATGAGTACCGTTTATCACCGTCCGGCTGACCCTTCAGGCGATGACAGTTACGTGCGACCGTTGTTTGCCGATCGTTGCCAGGCCGGTTTTCCTTCGCCTGCCACTGATTATGCTGAGCAGGAACTGGATCTGAACAGCTATTGCATCAGCAGACCTGCAGCCACCTTCTTTCTGCGCGCCAGCGGTGAATCGATGAACCAGGCTGGCGTGCAGAATGGTGATCTGCTGGTAGTGGACAGGGCCGAGAAACCACAACACGGGGACATCGTTATCGCTGAGATCGACGGTGAGTTCACCGTCAAACGACTGCTGTTGCGCCCACGCCCGGCACTGGAGCCGGTTTCAGACAGCCCGGAATTCCGCACACTGTATCCGGAAAACATCTGTATTTTTGGTGTTGTCACTCACGTGATACACAGGACGCGGGAGTTACGCTGATGTTTGCACTGGCTGATATCAACAGTTTCTACGCCTCATGTGAAAAAGTTTTCCGCCCGGACCTTCGCAACGAACCGGTCATCGTACTCAGCAATAACGATGGCTGTGTGATCGCGCGCAGCCCGGAGGCAAAAGCCCTTGGCATCAGAATGGGGCAGCCCTGGTTTCAGGTGAGACAGATGCGCCTGGAGAAGAAAATACATGTATTTTCCAGCAATTATGCGCTGTACCACAGCATGAGCCAACGGGTCATGGCTGTTCTGGAGTCGCTTTCTCCCGCAGTTGAGCCCTACTCAATTGATGAAATGTTCATTGATTTGCGGGGGATAAATCATTGCATCTCTCCGGAGGTTTTTGGTCATCAGCTCAGGGAACAGGTAAAGAGCTGGACAGGACTCACCATGGGGGTGGGCATTGCGCCTACAAAAACGCTGGCTAAAAGTGCACAGTGGGCAACAAAGCAATGGCCACAGTTTTCCGGAGTGGTCGCGCTGACGGCAGAAAACCGTAATCGGACCTTGAAGCTACTGGGGCTGCAGCCAGTTGGTGAGGTCTGGGGAGTAGGACGCAGACTGACGGAAAAGCTGAATGCGCTGGGTATTAACACAGCACTGCAGCTGGCGCAGGCTAACACGGCATTCATCCGGAAAAACTTCAGCGTCATTCTTGAGCGTACGGTACGCGAACTCAACGGCGAGTCCTGCATATCCCTGGAAGAAGCACCACCGGCAAAACAGCAGATTGTCTGTAGTCGCAGTTTTGGTGAACGAATCACAGACAAAGATGCCATGCACCAGGCTGTTGTTCAGTATGCAGAGCGGGCCGCAGAGAAACTACGTGGGGAGCGTCAGTATTGCCGGCAGGTGACGACATTTGTACGGACATCCCCCTTTGCAGTAAAAGAACCCTGTTACAGCAATGCCGCTGTGGAAAAGCTTCCATTGCCCACACAGGACAGCCGGGACATTATTGCCGCCGCATGCAGAGCCTTAAACCATGTCTGGCGTGAAGGGTACCGCTATATGAAGGCAGGAGTCATGCTGGCTGATTTCACACCATCGGGTATAGCGCAGCCGGGATTATTTGATGAAATCCAGCCCCGTAAAAACAGTGAAAAGTTAATGAAAACACTCGATGAACTGAACCAGTCGGGAAAAGGGAAAGTGTGGTTTGCGGGGCGAGGAACCGCCCCTGAATGGCAAATGAAACGGGAAATGTTGAGTCAGTGTTATACAACTAAATGGCGAGATATTCCCCTGGCCAGGCTGGGTTAGTTCAGTCATCTCCGAACATATTTTCAGCGTTTCTTCTGGTCTGGTCTTCACCGTCATTTCTCGACAGACTCTGCTCTGTAAGAGGAGTACTGCAATCCACAGACGTATGGAGACCAGATTGTTTTTCCAGTAATTCAAGCAATTTCTTTTCAACCGAAAAAGCACCTGGTATTACGCTGGAAATCACCTTATTAATATCATCCAGAGTCGTATTTTCTGTCAGTAACTCCGATATCAGCAAAGGAAGACGTTTATCTATAGCTGCAAACGCCGCACCAGTAACTAACATCGCGCGCATGAAACGTCCCCGCTCCTTCAGTTTTTCATTTGCAATGAGCTCATCTGCTATCTTATCTCCTGTCCGTTCATCCGGGAAAAGTTCAAATGAGCAGCGTCTGGATTTATTTTCATCACTCATTAGTCACACCACCTTTCATTTTTATCATTCCCATGACTAAATCAAACTGCGGGGATGAGCTCAGATAAAAGCGCTCATCAGGAACCTTAGTCAGGTTCTTCACAGCCTCGGCCACAATTTCAGCCCCACCACCAACACACATTACATGTGTATAGTCGGTGAAACGGCTGATGACATCATTAACTCGTTTAATAAGCAACTTCTGCCGTTCATTGATAACATTAATGATAGACTCACGCTGTTCAGCATTATAAATGCGACGGGAAAGGTAGTCAGGTTCATTACGGTGCACAATGATATTGTCAGCCTGGAATGAGCTCACTCTTGTATTAGCATGTACAGCCATCTGTTCCTTAACCCCGGATGTAATCAGGGACACGCCGATATTCGGATCACACCAGGTTTTTGTAATCCCTGTCATTTTGCTACGAACATGCGACACATCAAGAGTTGTACCACCGAGATCTACGATCAAAAGGGATTCATCATCCTCAAGCCCCGCAAGAACACTGAAACCAGCGGGAATACTTTCAGGAAGAACGGAAACACTGCGAATAACAAATGCATCACTCCCCTGCACCCGTACTTCACGCATCACATTTTTTTTCTTTCTTTCAATGTTTTGCTTATTTTTCTGATTGTTGGCGTCAAGGTATTCAGAGATCGGCAATGTGACGATGACATCAACAGGCTGCGCTTTCAGGCCGGTCTGCTGTAGCGCATGCTGAATGGCCACAACATTCACATCACTGTACTGATAGCGTGTTTCAGTCGTTACGACAGCATCAGCACTTAATGGATCAAATGAAAACTTCTCGCCGTCGATCTCGTAATTAGCCGGAGCAGCATCATCCAGTAAACTAAAAGACCATTCCGGTTTAAAGCTGTTAGGGCTGATTAACGTTTTCACGTCACCATCCTCCAACCAGGCAAGTTTAATGTTGGTAGAACCATCATCAATAAAGATTTTCATAACCAGTCTCCGTTGCTCATAAACAAATAGAAAAACAAACATGCCTCATACATGCAATGTATATTCAATTATAATGAAAAAACGGTCTTTCTGAAAGGACAAATGCAACATAAAAACACGATAAATTGCATGTACATTGTACACACAACTTTAAGACCAGAGGAAATCATAGATACAAAAACATTATGAAGGTTATATGTGACACATAAATGCAATATAAAAACATCGTGGACATCATGGTTCAGGTTAAGGGAAAAGGAATGAAATGGTGAAACTGAGAGGAAAGGAAAGCGGTGACGAATCATGTCACCATAAACAGAAAGATGTCTAATGGGGACTCTTTAGGTACGTGAAGAATCCCCATAACGCATTTAAAAGACACACATCAGATACCCTTAAGGTATCCGATAGTTTATTGACCTATTGCACCATCACGTTCAAGCTTCTCTCTTATAGCCTCAATAATATATGAGCTAAAATCCAGAGATGTTTTACTGGTCGCTTTAAGTTCCGCATGAGCTTCAAAATACGACAGCGGTATGGCCTTAAGATTCTTAGCCTTCGTCCTGGCAGCCACGGGACGACCTGAAACTTCCTCTGCACCTTCATTTGGCTGAGACGGGGCTGTTGCTGTTACGGCAGAAGAAGAAGTTTGTAATCTGGCAGAATCCACCAGGTTTTTCAGTTTTTCAGCCTGTGCACTAAATTTCGCTTTGCTCATGAGATAACCCAGGATGTTTGTTAGATACTTAAAAGATATCCATTAAAAGCCCAAAGGATACTATATGGATACCCAATAGACACACCTTACTGTTTGTTATTTTCAATCAGATGATTGATTTCTTCGATCAGGGCAATAACTTCCTTACCTCCTGCCGAATAGCGCCCATGAACAGACTCAGTGATTCCCATCCCAGTCTCAATGACATCCTCAAATTCTGCACGAGCAGAAATGCGGCTCTTCATCAGCTTCAGATGTTTGAACGATGGCAGGATTGCATCAAGCTTAGGGAATTTCTTCTTGTTAGGATTAACTTTACAGAGATACAGGTGAGCAGTTATATCGGTCCCCATGATAGAGCTGATTTCGTCCAGTACTCCATCAAAATGCATCAAACCAATACGTTCAGTCAGGGAGTCTTTTGAAGGGACAATAACGCAGTCTGCAAAGGCAATCGCAGTACGGGTAAGATCTGAGTCAAATCCCCCACAGTCAATAAGTAACGTCTTATCGCTGTTCTTGTAGGGAGTCATAATTTCGATTAACTCATCCACTGTTTTGGGTACTTTCACGGAAATTTCTTTTCCTTCAGGTCTCAGCCCCAGAATGATAGAAAGCCCGGTATGAGTATCCAGATCAACTGTATCAGACTTCATTTCACCAACAATGTTTACGGATGAAGTTGTCTTACCCACACCACCTTTGGGATGCGTATTAGCAATAACAGGCATAGTGTATCTCCAGAATCCACATGTAATACCCATAAAGACCCCATAAGACACCTTTCGGATATCCAAGAGGTACTCAATAGATGTTTTTTTACTCTATACCGGTCCTGCATGTCAACAGAATATGAAATACCGATAATATATCCATGAGATATCCGAAAGGGATTTAAAAAAGTCAGAGCTTATGGAATTCTTTTGAGCATAGACACCGCATCGGACTCAGGCATCGAAAACTGCACCCGGTGCCGTGCAGCCACATCCAGTGCAAACACCTTCGTGTAGACCTCCGTTGAGCTGATGGACTTATGCCCCATCAGGCTCTGCAGGACCTTCAGCGGTATACCGGCATACAGCATATGCATCGCATAGGAATGGCGGAACGTATGTGGCGTGACCGGGACAGAGAACGTCACACCGTCAGCGGCAGCGGCGGCAACCGCCTCCCCAATCCAGGTCCTGACCGTTCTGTCCGTCACTTCCCAGATCCGCGCTTTCTCTGTCCTGCCTGTTCGTTTATTACGCCGTTCCATGGGGATTTTCAGTGTGGCCACCATCGTCTGCAGCTGGCTGACGTACCAGGTGTCGGAAAGCGGAACCAGCCGGTGAGTCTGCTGACCGGCGGGCATCCTTCCTGCCGTCCTGGCGGCTTTTTCTGTCCGCTGCTTCAGAGTGGCCAGCTGCACAAACGGATACGGGGGCGTGAGCGAAAAATCCCCCCGCGTCAGCGCCAGTGCTTCATTAATGCGCGCACCGGTGTTCCACAGTGTGGCCAGCAGCATCTTGCGGCGCAGATCCGGGACGTAATGGAGCAGGGCGCTCACTTCAGGGGCCAGCAGGTATTTGGGCAGTTCATCATGAACCATCGACATCTGGCGGAGTGCCAGCGCTGCCGGATAATCGATGGCAACAGGAAGCTGAGCGGCATCCCGGGCATGGTGGATCGGTGCTGGCAGGTGCTGCATATCAGTGTTCACTCCACGGGGAAACGTCGGGCAGGTTTTCCACAACCCGGTACTTTCCCGGATAACGGAGCTGGTTACCGCCACGCGTCCAGACGGTGACAACAAACCCCCCTCCCTGGTTGTTTTCGGGGAGCAGGCGATCGCACTGCTCACTCAGCATGTGGATCACGAACGGCGCATCGCTGCCGTCTTCAAATACCAGTTCCAGCGCATCGCGGCCATGCAGCGTTCCCTTACTGATGATGACGTACTCAGCCCCCCGCATCTCCCTGAGTAAATGTTTTGCCGCATCCGGGACAAGCAGCCTGGCTGCGCCGGCATTCCAGCTGAGGTAGACATATCCGGCCTGCGCCTGTACAGACTGCCAGTAATCCGTTCTGGCAACAGCCTGACCTTCATTCTCAATAAAAAACATGGGTGACTCCTTTTTTCTTTTCCGGGCAGGGACGGTCATGCGATAACGTCATCCATCATCACTGCCCTTACCGTCACGCCGTCTGATAACATCATGCCGTTATCATCATCACCATGATAACAAGCATCCATATAACCACGCCGTTAAATTACCGGAGAGCCGTTTCCGTCAGATCCGACTTTCCGGAATATCACAACTTTCCGGAAGTGTACCACGCTGAGAAAATAATCATATCGCTGTTTTCCGCCCCTGCGCGGCGCATCACAGGTCAGGGAGATGACACAACATATAGTGTCATAAGCAGCTGAATGAGATACCACATGTTGTGCTGACAGGAGGTGGCGTTATGTGGGGGGAGAGGAAGATCCTGAACCGCCGGAAACCGGATCTGCGCGGCGGGAAACGGGCAAGTGATATGGTAATTGAGCAATACACACAAAATCATATCAGATATGATTTTCATCATTGATGATAAAACCATATCTGATATTATCAGAAATCAGGAGCACACAAATCATACAGGATATTATTTTTACCTGTCAGAACATTATCAGATGGAGCGTGCAGGATGGATGAAGAAAGGGTGTTTTCACTCAGCTATGAGCAACTAACCCGAATAGCGGAAAAAAATATCCGTGAATGTGGGCTGGACAACCAGAGCGCCAGGTGTATCAGTGAACTGAAGGCCTCAGCTCTGCTGTGGTTGTGGTATGAACTGGCCATTCATGGTGCGCCACAGAACAATCACGCACAGGCCCGGGAACGCATCGATACCGATTATCAGCGCCTCAAAAAACTCATCTGGTCGGAGGGTGACAGTTAATGACTCAGAGCCGCCGACCGTCGCCACTGCAGCGGAGAGTGCTGATTGTGCTGGCTGCGCTTGATGAAAAACGGCCGGGCCCCGTGCTGACGCGGGACCTGGAACGGGTGCTGGAGCGAAGCGGGGAAGCCCCGGTCTACGGGCCAAACCTGCGCGCCTCCTGCCGTCGTCTGGAGGATGCCGGCTGGCTGCGTACCCTGCGCGCCCCGAACCTGCAGCTGGCAGTGGAGCTGACGGACGCCGGCCGGGCCGTGGCACAGCCTCTGCTGCTGGCAGAACAGGACCGCCTCCGGGCAGAACAGCGTGCGGCAGAAGTCGTCGTACTGCCGCTGGTCCCGGCAGCAGGTCTGCCCGCAGACGGCACTTCTGCCACTGATCTGGCGGTGGAGCTGAACGGCATAACGTATCAGGCCTGCCGCGGGGATTTTGTGGTGCGTCTCGACGGCAGCACCTGTCTGCAGTTATGGAATAAAGAAGGCAGGGTGGTACGCCGGGAGGGCGATCCGCTGGAAGTGGCGCAGTGGCTGCAGGCCTGTCATGACGCAGGAATAGAGGTTCGCGTACAGATAAATGAAAGTGCCGCTCCGTAAGAACACGCCTGTGCACGGTTTACACATCATCCCATGGTGGCAGCCGGTTAACTTTCCTGCGCCACCAGTGGAAAGAGGCCATGCACAGTCCGAACAAAAAACCACCCGTGATACTTATAATAATGGCCTCACCTGCCACCATTCCTGACGGCCCCCAGTAGGTAAACCACATTACACATCCCCAGGAAATGCCCCATAAGCCCCCCGTCAGCACCGTGACCTGCCAGAACGGCATAAAGGGTAATGGCGGAAGCCGGATACCCAGCCGCCATAGAATACGCAGAAGAGGAGGGGCATAATTGCTCCGCCACATCTTTTTGCTGTCCATCAGGGCAATGGCCCGGGCTTTTTTCTGCTCAAAGGTCACAGGAGCACCTCCGTTCCATGATGTAAACGTGACACAGCTTATTGTTATTGATTATTATTATCATGCTGTGGTTATGTTGTCATGCATCAGTACACTGACAAAAGTGCAAAAGAAAGGAAAACTGGCAGATGAACAGAAAATATTATTTTAATAATATGTGGTGGGGATGGGTGACGGGGGGATATATGCTGTATATGTCATGGGATTATGAGTTTAAATACAGATTACTGTTCTGGTGTATTTCTCTCTGCGGAATGGTTTTGTATCCGGTTGCAAAATGGTATATTGAAGATACAGCTCTGAAATTTACCCGGCCTGATTTCTGGAACAGCGGTTTTTTTGCTGATACACCTGGAAAAATGGGGTTGCTTGCGGTTTATACGGGTACTGTTTTCATATTATCTCTTCCGTTAAGTATGATATATATTCTTTCTGTTATTATAAAAAGGCTGTCTGTAAGATAGACAGCCTGTCTTATATTTTATTTAAATACCCCAGAACTTATTCGCTTTTTCCACAAGCGATTCATCAATCAGCGCACCGGTGACAGCCATCAGTAAACCATACCCGATAATGCCTAAAGCGCTTCCGGTAAGAATACTGAAGACCAGTGCCACAAGAGCCGTTGCGGCATTGCCTGCTATGATGGTTTCTGTTTTAACAAAAAGAGGACGCCAGTTCTCTGTCCGGACAGCCTTACCAAACTCAGTGATCCAGTCAGCAAGACTTGTAAATTTTCCTGCATATCCCAGTCCCCGACTGAATCTGTTCAGATTAGACGATATATCAGACAGCTTCACAGACTCAAGGGCTGCGGCAATCGCTGCACGATCTTTTGCATTAATTTTTTTGTTAATGTCAGCCCGGTACTTTTCATACGTTTTTAATGCCTCTTCAACATTACGTATTTTCTTCCCTTTAGCCTGCCCGGCCATCTCTCTGGCTAACTGCTCAGCTTTTGCACCATATTTTTCTGAAACTGATTTCAGGAACTCTGTTGTGAAATTAATTGCGTCTTTCGTTGCCTTCAGTTCATCCTGTTTTCTTTTCTCTTCCGCTATCTTCTGATTGATGCCGGAAAGCTGGTTACGGATATTCTCTTTTTCCTTCAACAGGGCATTAAGAGCGTCATTTGCATGCTTTTGCTCATTTGTTCTGGCACTGAGGTTATTTCTCGCCGAATTTACCGCAGATTCAGCAGAGGTGATTTTATTTCTGGCATCAAGCAATCTTTGCCGTAACTTATCCCATTCAGCAACTTCAGCATTATAAATTTTCTTGTCACCTTCCACATCCTCTGTCACCACCGGATTCTGGTCATTCAGAATATTGCGTTTATAGTCCAGACCGGAATGGCTCAGAAGATAATTCAGGTTTGCACGGTTATCGATGACTGCGCTGGTTGTGATTTTTATCGTACCGGCAAATCTCGGATCACCGCTCACAACAATAGAATGATTTGTTGATGAACGCCCCGGGAATTTTTCAGGGGAAACTATCGTTTTGCCGTCAGGCGTGTTTTTCTGTTGCGTCAGCTGTTGTTCAGCTCTGGTTAATGCATTACGGGCCGTGTTAAGCGATTCCGTCACTGAACTGAGTTTATTCCGGGCCTCTGAAATGGCCCTGTCATTCCGTGTCTGCTGCCCGAGCAGACGGGCCTGTTGTGCATCAAGAACGGCAAGGGCTGCCCCGCCATTTTTTTCCAGCTCTGACAACCGGGTGTCCAGAATACCTTTTCTGCGCTCGTATTCAGCAAGCATATCAGCGGCCTTCTTGTCTGCGTTCTGCGCATCCTTCTGCCGTTTTTCAGCCTGTTCGATTAACGACCTGGCCTCCCGGGGAGATATACGAAGAGAATCAGCATCAGCAAACAGCATCCGGCTCTCTGTATGCAGCCGGAGGGCGTCATATCCGGCGATTTCAGTACGGAATCCGTATTCTCTCAGCTCTGCCTGCAGGAGTCTGAACTCCTGTCGTGTAATATCAGCGGCATCTGCGTTTCCGGCACGGAGTGTTTTCAGTGTGTTTTCATCTTTTTCCCTTGCAGCAATCGCCGCAGAGAGGCGTTTTCCGGCTTCAGTACGCTTATTCTCATTCTCTTTCTGCTGCGCGCTGAGCGTGTTTTTGTACGCTGTGATTTCCTTGTCCCTTTTTTCGATATCACTTCGGGTTGGGGAATCATCAACCCACTCGTTTCCGCCCCAGATGGTTTTGTTCCCGAAGGAACTCCATGCAGGCGGGGTACCATGAAAGACATCGACACGTGGAGGGTTTACATAAATATCAACGGCCATAATTTCATGGCCATCTGAATCATACCCCAGCGATTCTGCACCGGGATTTGTAATACGTACAGGGTCAGACATTCGGTATCTCCTTCATCCTCTGAGGAAAACAAATGAATTAACTGCTTACGCATATGGATACATATACAGTATTAATTTATTAAGGAGAAAATGGCATGTCAAGATTTGATGATAGTGATTATCATTAACATGAAGTGATGTTACACCGTTCAGAAAGCCTGCTGACGCTGTGGCAGCATCACAGTCTGGGTATTCTCTGGTGCAATACAAAAACCGGACTTTCCCGTAACAACAGACAATGTTACGGGAAAAGTTACAGAACTGAGCCACAAAATATCTCAGTACCTGAGATGCATAAAAACACCGTACATATGTTTCTTAAAAGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTGCAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCAGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAACACGGGATAATACCGCACCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGAAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTACCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCTAAGAAACCATTATTATCATGACATTAACCTATAAAAATAGGCGTATCACGAGGCCCTTTCGTCTTCAAGAATTTTATAAACCGTGGAGCGGGCAATACTGAGCTGATGAGCAATTTCCGTTGCACCAGTGCCCTTCTGATGAAGCGTCAGCACGACGTTCCTGTCCACGGTACGCCTGCGGCCAAATTTGATTCCTTTCAGCTTTGCTTCCTGTCGGCCCTCATTCGTGCGTTCTAGGATCCTCCGGCGTTCAGCCTGTGCCACAGCCGACAGGATGGTGACCACCATTTGCCCCATATCACCGTCGGTACTGATCCCGTCATCAATGAACCGGACTGCCACGCCCTGAGCGTCAAATTCCTTTATCAGTTGGATCATATCGGCAGTGTCGCGGCCAAGACGGTCGAGCTTCTTAACCAGAATGACATCACCTTCCTCCACCTTCATCCTCAGCAAATCCAGCCCTTCCCGGTCTGTTGAACTGCCGGATGCCTTATCGGTAAATATACGGTTTGCTTTCACACCTGCGTCTTTGAGTGCTCTGACCTGAAGATCAAGAGACTGCTGACTGGTTGAGACCCGAGCGTAACCAAAAAGTCGCATAAAAATGTACCTTAAATCGAATATCGGACAACTCATGTCTATTATTACAAATTTACGATTTAATAGACATATTAATGTAACAGTTTTACGATGTCCGATAATTTATAACATTTCGTACGGTTGGAAAAATGTTACTAAATGCCCGTCAGGCAGGGAGGCCGATATGCCCGTTGACTTTCTGACCACTGAGCAGACTGAAAGCTATGGCAGATTCACCGGTGAACCGGATGAGCTTCAGCTGGCACGATATTTTCACCTTGATGAAGCAGACAAGGAATTTATCGGAAAAAGCAGAGGTGATCACAACCGTCTGGGCATTGCCCTGCAAATTGGATGTGTCCGTTTTCTGGGCACCTTCCTCACCGATATGAATCATATTCCTTCCGGCGTCCGGCATTTTACCGCCAGACAGCTCGGGATTCGTGATATCACCGTTCTTGCAGAATACGGTCAGAGGGAAAATACCCGCCGTGAGCATGCAGCGCTGATACGTCAGCACTATCAGTATCGTGAATTTGCCTGGCCCTGGACATTTCGCCTTACCCGTCTTTTATATACCCGGAGCTGGATAAGCAACGAACGTCCTGGCCTGCTTTTCGATCTGGCGACAGGGTGGCTTATGCAACATCGTATTATTCTCCCCGGAGCCACTACGCTGACCCGGTTGATTTCAGAGGTAAGGGAAAAGGCGACGTTGCGCCTGTGGAACAAACTGGCACTGATACCGTCAGCCGAACAGCGTTCACAGCTGGAGATGCTGCTGGGGCCAACTGATTGCAGCCGCCTGTCTTTACTGGAATCACTGAAAAAGGGCCCTGTGACCATCAGTGGTCCGGCGTTTAATGAAGCAATTGAACGCTGGAAAACTCTGAACGATTTTGGCCTGCATGCTGAAAACCTGAGTACACTCCCGGCTGTGCGCCTGAAAAATCTCGCACGTTATGCTGGTATGACTTCGGTGTTCAATATTGCCAGGATGTCACCGCAGAAAAGGATGGCGGTTCTGGTTGCCTTTGTCCTTGCATGGGAAACGCTGGCGCTGGATGATGCATTGGACGTTCTGGACGCCATGCTGGCCGTTATCATCCGTGACGCCAGAAAGATTGGGCAGAAAAAACGGCTCCGCTCGCTGAAGGATCTGGATAAATCTGCATTGGCGCTCGCCAGCGCATGTTCGTACCTGCTGAAAGAAGAAACACCGGACGAATCGATTCGTGCTGAGGTGTTCAGCTACATCCCAAGGCAAAAGCTGGCTGAAATCATCACGCTTGTCCGTGAAATTGCCCGGCCCTCAGACGATAATTTTCATGAAGAAATGGTGGAGCAGTACGGGCGCGTTCGTCGTTTCCTGCCCCATCTGCTGAATACCGTTAAATTTTCATCCGCACCTGCCGGGGTTACCACTCTGAATGCCTGTGACTACCTCAGCCGGGAGTTCAGCTCACGGCGGCAGTTTTTTGACGACGCACCAACGGAAATTATCAGTCGGTCATGGAAACGGCTGGTGATTAACAAGGAAAAACATATCACCCGCAGGGGATACACGCTCTGCTTTCTCAGTAAACTGCAGGATAGTCTGAGGCGGAGGGATGTCTACGTTACCGGCAGTAACCGGTGGGGAGATCCTCGTGCAAGATTACTACAGGGTGCTGACTGGCAGGCAAACCGGATTAAGGTTTATCGTTCTTTGGGGCACCCGACAGACCCGCAGGAAGCAATAAAATCTCTGGGTCATCAGCTTGATAGTCGTTACAGACAGGTTGCTGCACGTCTTTGCGAAAATGAGGCTGTCGAACTCGATGTTTCTGGCCCGAAGCCCCGGTTGACAATTTCTCCCCTCGCCAGTCTTGATGAGCCGGACAGTCTGAAACGACTGAGCAAAATGATCAGTGATCTACTCCCTCCGGTGGATTTAACGGAGTTGCTGCTCGAAATTAACGCCCATACCGGATTTGCTGATGAGTTTTTCCATGCTAGTGAAGCCAGTGCCAGAGTTGATGATCTGCCCGTCAGCATCAGCGCCGTGCTGATGGCTGAAGCCTGCAATATCGGTCTGGAACCACTGATCAGATCAAATGTTCCTGCACTGACCCGACACCGGCTGAACTGGACAAAAGCGAACTATCTGCGGGCTGAAACTATCACCAGCGCTAATGCCAGACTGGTTGATTTTCAGGCAACGCTGCCACTGGCACAGATATGGGGTGGAGGAGAAGTGGCATCTGCAGATGGAATGCGCTTTGTTACGCCAGTCAGAACAATCAATGCCGGACCGAACCGCAAATACTTTGGTAATAACAGAGGGATCACCTGGTACAACTTTGTGTCCGATCAGTATTCCGGCTTTCATGGCATCGTTATACCGGGGACGCTGAGGGACTCTATCTTTGTGCTGGAAGGTCTTCTGGAACAGGAGACCGGGCTGAATCCAACCGAAATTATGACCGATACAGCAGGTGCCAGCGAACTTGTCTTTGGCCTTTTCTGGCTGCTGGGATACCAGTTTTCTCCACGCCTGGCTGATGCCGGTGCTTCGGTTTTCTGGCGAATGGACCATGATGCCGACTATGGCGTGCTGAATGATATTGCCAGAGGGCAATCAGATCCCCGAAAAATAGTCCTTCAGTGGGACGAAATGATCCGGACCGCTGGCTCCCTGAAGCTGGGCAAAGTACAGGTTTCAGTGCTGGTCCGTTCATTGCTGAAAAGTGAACGTCCTTCCGGACTGACTCAGGCAATCATTGAAGTGGGGCGCATCAACAAAACGCTGTATCTGCTTAATTATATTGATGATGAAGATTACCGCCGGCGCATTCTGACCCAGCTTAATCGGGGAGAAAGTCGCCATGCCGTTGCCAGAGCCATCTGTCACGGTCAAAAAGGTGAGATAAGAAAACGATATACCGACGGTCAGGAAGATCAACTGGGCACACTGGGGCTGGTCACTAACGCCGTCGTGTTATGGAACACTATTTATATGCAGGCAGCCCTGGATCATCTCCGGGCGCAGGGTGAAACACTGAATGATGAAGATATCGCACGCCTCTCCCCGCTTTGCCACGGACATATCAATATGCTCGGCCATTATTCCTTCACGCTGGCAGAACTGGTGACCAAAGGACATCTGAGACCATTAAAAGAGGCGTCAGAGGCAGAAAACGTTGCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCTAAAAGGGGGATGATCGTTATCCAGCCATTTCGGTGGATCGGTATGCAGAACACCAATCTGCTTCATGCCGGTATGCTGCCTGGATTTTCTCGCGCAGTAATCACTGTCTTCATATCCCATCGTTTCGATGACCACTCTGGCCGTCTTTCCGTCAGGAGCCCTTGCTGTGACAATGAAATCCGGCAGTACATATTTCTTTTCACCATTAACATAAACTTCTGTATCAAACAGGGGCCTTTCCAGACTTAATTCCGGCGTACCTGGCTTTCTTTTAAGCCAGCTGGCCACATTCAGAAGAGCAGTGAGCGTGTTTCGTTCCAGTTTGCTGTCCACAGGCACCGGACATGTCAGTTGATAAAGAGCATGAGCATACCCTTCACTGCAGATGATTCTGCCATCGGCACTCCGGCAAAAAGCAAGAATAACCCAGTAAGGGGGACGTATTCCGCCCTGCGCTTCACCATTAATACTGATCCCCCGCACAGGTCTGATGACCTGAATATTACCGTTCGCCCAGTGAATTTCCACAGCATCACGACAGATGTGCTGCGCCATAAAAATCTGAAAGAACATATGCTTTCTTCTGGCAGGCCAGTGTCGTTCTGAATTCTCCAGCGTTTCCATTAACCGCTCCTGAGACCTTTCAGACATTCCTGGCCGGAAATGGATAATTTCAGATAAGGCTCTTCCCCGAATATACTCCTGCTGTAGTGTAACCTGCCGTATGGCATCAAGACACTCACGATAATTAGTCCGGATACGGGGATTAGCCAGGGAATCCAGTTTATTCAGCCCTGCATCTTCAATAAGCGACAGGAGTAAACGGCCAAGGCGCGGACGTTTCTTGCGAACGGAGGAGCGCTCACCATTATGGTAAGCAGAGCGGGCCTGCAGTCTGATAACAGAATTACTGTCATCAGGTGGTAAAAAGTTTCTGTAATTTATACGGGTGCTAACGGGATGCCGGCTTGCTCCGAAGGATGTTTCCTCTTCATTTCCGGATAACTGACGATACATGGGGCATTCAGGTGCATGCTCATGATTAAAACTGGACAGATAAAGAGTACCCGTATTGTTTTTAAGAGCAGCAAAATTCATGGCCGGCGAATCTCCCGGAATACAGTCACACTGTAACCATGCATCATACTCACGCATTTCCCGGAGAAGATCATTGGCCAGGTTATGTTGTGCCATGGTTGCTGGCCTTTTCAGTCCACAGACCGTCTTTACTGCAGTCTCTTCCTCACTGCTAAGCTCCCGAATCACTTTGCCCCGGGGATTCTTCTTTACAAGTATCATTGGCATAATGAAAGCACTCCTTATGTACATGCTTAAACAGTAAGTAAAATATACAAAGAACCCCCCATGAAACAAAGGCAGAGATGAACTGTGCGCCCCGATATCTTCTTCTGATATCCTTTCAAATGAATTGTTTTTATTTATATCATGACAACATTAAAGTGAGAGAATATATCAACCATGTTTCTATCAGGGTTCAGTAGAATATCAATTCGACTGTCACGCCATAACTGTAACTACCTCGAGTATAAATATTCAGAGAATGGACTTATTAGCCATGAAAAATCACCTGATGGGAAATTTACTAATTTATGGATTGTGATATTATTAAAGAGTAAAACCAGCCAGCCGAGGTATTTATGGGAAAAAATCAGGAAGAAAGGAAAACTCCCGTCATTGTGGTGAAAAAACGTCGAACTTTTTCGCCACCGTCCTTATCCGAAAAAACAGATATTATCGCACCTGTATTTACTGAACAGACGGCAGAATCAGCCCCCGCCGGAATAAATTCATCTGCCGTCGAAACACATATCCCCGAAGCGCCAGCCAGGAAGAAGAAAAAGAAAAGACACCGTTTTCCACGTCCCTCCCACTGGACCCGTGAGTATACTCATGAGTGCGTGGAAAAAATAAAGGCCCTGTTTCCTCATCTTCGTGCTGAAGGTGGTGGATTTATTCCCCTGAAAATTGGCATAAGCAATGATATTTCGGCATTTCTGGCAGAACACCCGGAGACAGAACTGACCATGGACGAATGGCTCTGTGCAGTGTCCTGCATCACATCCCGCCGCGTATATCTGCAGCGGACAGCTGTCGCCGGCGTCCCACGTTATGGCCTGGATGGTCACCCCAAAGGGCAGGTCTCAGACTCTGAAGCACAGAGTGCCGGTCGCAGACTGGCGACATTAGAACAAAAGTGGCTCAGGACGCAGGCACAGCAGGAGAATATTTCTGGGCAATAAACACTCCTGATAACAGGTGGACATTACGTATCAGAAAAAATGGGAAGAGAATGTTATGTGTGATTCAGAAGCGGAGAAGATTTTATTCATCCTGAATAAACATGAACGGGCATACAGACGCCTGATCCCCGTATATATTTTTTTAGCTATAGTATTATGGATTTTACCTATTCTCCTGATTGTATACTTGTATTTCTGTATAGTTGACAATGAGTTTCTCAGAATCGGTTTCTGTATTGCATGGACAGCATACTACTTTCTTTCGCTTTTCAAGTATTTTGTAAAATACTTCTTTCCTCTCGATCGTGAAGATTTGCTTAAACTGATGGATCTCGCCAAAGATTCTCCTGATGCGAAACAGGAGCTTCTTGAGCGTCTTTTGTCCGGAAAAAGAATGACCGGGCGGGATGAAATGGATATCAAGCACATTCTAAAAACAAAGGAAGCACTTGATAACATCAGGAATTTTATTGATAAACAGCAGTTAACGAATAGTGATACTCCGAAGAAAAGCACGGTCCCAAATGAAGATAAAAAAGGCATAAGATGATGATCACAGGAAATGGAATAAACACTGTAACTGTCAATGGAAAAGTGAAACACATCACAGAACTGGATGATATAACACTTTGTTTAGAGTGGACAAAACTACGAGAGGAAAACAATCGTCTTTATGAAATTAATAACCAGGCAAACAGAGGATGGCGTGGTTTCATCCTAAGATTGATAGGGGTTAACCTGCCAGATAAAAGGACTGAGTTTACACAATGTCTCTTATTGACGCGCAATATTTCTGGTTCGGTCATGAAAAAGTAACATATTCTATGCTGGAACAGACCAATTTTGCATTCTCCGTCCAAGAGTTTGAGGGGAAAGTAGTCAGTGTTTTACGCTCAGTCAGGGAAAGTGTGCAATGATAAATGACACGAAAGGAATCGTAGTACATGGGCACCGCGATTCAATATTCAAGGAAAACACAATACAGCAATGTACTTGTACTGTTTCTATTATTATGGCGATTTCAATAAAGGCACTTGCTCGCGCTCTGTCATTTTCTGAAACTCTTCATGCTGCATTTCGATTTTCCTTCTAAGATCATAACTCGCATACCCGTTCTTTTTATGCATATCCATATCTATTTTTGTGACGAGTTCAAACCACAATGTTCGCACTCCCCATGCAGCGTTATGAAACATTTCCGCAACGGCAATAGAGTCTGTATTAACTGCTTCAGTCATGTAGTCGCTAATACGTTCAGCGGTAATTTTCGTTATTTCATCGTAATTCATTTTATCTCCTACAAGATTATTTAATGGAATGCAAAATATCTGGCGTGATAATAATGTTCCAGAATTAATATCTGCAGGCTATGTTAAGTTGTCCCCACACACAATCTACCTGTTTTCTCGTGTGTGCCACAGGCGCAATACATAAATAGTCTGGTCATTAAGTTCGTAACGGATTTCGTACTCGCCAGCAAAAATCCGTCTGACCTCCCTGGGTTCAAACTGAAACAACTGTTCTCCCATACGTGGATGAGTTAACAGAATGACCGGTGCCTGTGTCAGGGACTGTACCGTTCTGGCGGCAGCAGGTTTACTGGCCAGCACCAGAAAATCATATAACCGCGCCAAATCAGAAAGCGCCTTACTGGTCCACTTCAGTTCCATCAGCGTGGCACCGGTAACGGATTGTCAGTACTGAGGCTGTCCGCCCAGGCCTGTACAGCCTGATGGTCGATAACCTGTCCGGATGTCACATCGTCCAGGGCTTCCAGCGTCAGGCGATTACGCTCCTCCTCCTGGGCAAGCCATGCAGAAAGCGCCTGTTTGATAACCCAGCCCCGGGAGCGTTCCAGCCTGGCGGCCATCTGGTCGACTTTATCAGCCATAGGTAATGGCACATGCGCGGTAATTACTTTTGTTGCCTGTGCGGTATTGTTTTTCATTTGCATATCCGATTAGTTGTTAATCATATTTAATCATAGTGATTACTTTCAGACGGAACAAGGCAAATAATGCGCGTCAGCGCATGTAAGGCGGCATACGGTGGTTACATGTAGCACAGGTGTGAAACCGCCGAAGCCCGGCGTAAGCCGGTACGGATTGATAGATTTCACCTTACCCATCCCCAGCCCTGCCAGACCATACCTGCTTTCAGCCATGAGAGAGTTTCTGTGCGCGGTCGGAGTGGTCCCGACGAGGGTTTACCCGAAGCCGGGGCGTATCTCCGCGTTAGCGGGCCGTCAGGGCCGCTTACGAGCGTGTACTCGATACTTCCAGCCAGAACACTGACAGCCATGATGAGATGTAGTTACAACATTCATAATTAAAAGCGATGTTGTTCCCGCCCTTTGGGCGGGGGCGGCCTCGCTTTTCAGTTATGAGGGGTGGGCACGGTGCTGCGTTTGTGTGGTGTTTTTATTCCTGATGTTTTTTTGTTGTGGTTTCAGAACGGTGAGGTTCGGGGCCCGCGCGTCAGCGTGGGAGGTGCTTTTAGATTCTGAGCGGCGCGGCCTTGGCCGCTGCAAGCGAAGGCCTCTTTGTATTTGTTCACAGTGGTTTCAGAGATAAAGACTTTCCCTGCGGCGAAGCAACGCAGGGGATTAAGTAATGGGGTTAAGACTATATTGCAGGTTTGCTGTTTCAGGTTTGCAGCTTCTTAAAGTCCTTTATTTGCGGATTTATGTGGATAACTGAAACGACGTGGCCATGTTCTGATGACTGATGCGTGGTTTTATGGGCAGATATGCCCCTCTGAGGGGATTTAAGGTGATTACTGCGGATTTTGGGCTGAGCGGAACCAGCGCCGAAAGCCCCGGAGGGGCTGGTGATGATTCAGTGCTGAGGGAATGGTGCTGTCTAGTGCGGTGGCGGGGCAGCCAGCGTCAGTTCAAGCTGACGCAACTCCCTGATGGCCATTCGCTTCAGATGGTCATCGGAACAAAAATAGGCTTCATCCGGAGGCAGACGCTTCCTGAGATACTCTGCCATCTCATGAATCTGCTGGTCGGCAGGCAGTTTCTTCAGGCGTCTGGCGCGCTTACTGGCTGCTGCTTTCGCACGACGGTGTTTCAGCGCATCCTGACTGCGCTGCAGATACCAGCGTTTTCTGGCCGCATGTACGGAGATATCTTCATCCTCACGCAGAACACCTTCCCGAATGAGCTGCTGGCGGATTTCACTTTCACGCAGTCGTTTCTGCTGCTGTTCGTGAAGTTTTACCATGTCGACGCCCAGCATCTGCCAGCCTGCCGGTGTTATCCAGACGTAACGTGGCAGACGCTGGCGGGTTTCACGGTCCCACAGGGTTTCCTCTGAAACACCCAGCACACCAAAACGTACCTGTTCGGCCAGCAAACGGGAAAGGCGGGAGACCGTCACTTCCAGTTCCGGAATAACCTTCCCCTTGCTGTCTTTCGGGCTGATTTCTCGGGCCAGACGGGAAACACTCATGCCTACGGTATGTGTGCCCGCATCACTGAAGCTGACCAGAACCGGCCAGATGGCATCGAGGAGGCGTTGTTTTTCCGGACGGAAAGCATATTTGCGACCGGCATACGTTCGTTTCTGCACGTAAAAAGGATGCAGAGACATGTGCATGCGCAGGCTCTGCTCGCCGGTCACCGGGTCCTTTTTCACCAGACGGTTGTAGGCGTGCCCGAGCTGCCCGCTCAGCGCCTTATAGCGCGCAGGACGATACCAGGACGGATTTTCGCATTTGGGTTTGGTGGAGTGTTCACCGCGACGGCGCTTCGTGCGCTTCCTTTCCGGTTCAACCAGGAAAGTGGTCGCCCTTCCCGCTTCATAGTCTTCCCAGAAACGGATCTGCTCTTCGGGTGCTAACTGACTCCAGTGTACTGCGTTATATGGAGTATTCTTCAGACCTGCCACAAGCTGTCGCTTATGGCGGAGCGATTGTGCCGTGTATTTATACACTGCACAGGGTTGAATCTCTGGTACGGTTTCATTATACTTTACCCGTATTCTGTGAGGCCCCCACTATCTTTCGTCGTTCCGCCAAGTTCGTAAGAAAGATAGTGGGGGTTTTCCTTTTATGGCTTCCGGAACATCTTCAGTCTTCTGACTTACTGCCCGTACATGCCATCTCTCCTGAATGCCTTATGGCGCATTCTGCCGTCCGACTTTCGCCGCTTTGCTCCACAGAGTGCCACCCTCTGCACAGCTAATAACAGCCGAAATATACCCGCTTTACGTTAATTTGAAAAGCATTACAACGATCTCTTCTCTTCCAGTGCCTCCTCACTGATACCTCTAATAAGTTAATCTTGACCTGCGTCAAAAAAATAAAATCTATTTTTAAAAGCAGATTTTTCTGCTTTAGATCCTTCTATTGGATTAAAAGATCGACTTTTGTCCTACTCACGATCATTTATCTTACAACCGATCCACCTAACAGAATAATATTCTGTTTTAATGCGATTAAACGATCTAAAAAACCTTTGAAAAATCATTTTGTAGATCATTCGATCGTAAATAGAATAATTCTTAGATGATAAAACCATTTGTTACACAACCCGCCAATTGTGTAACAACAGCCTCTACAAGAGCATATTTGTTCATATGTTCGTCAGAACTGCGGATTGTCTGGACGAGGGTCAGACACCGTTTCGTGCATATGGACCAGCATGTTCGAACGCCACAAAGCAGAAGCATCATGCCTGGATCGCTTCGGCGCGGAGCGTTAAGTTTTGACGCTTTTTTGTATGTTTTTTAAGCTGTTAGTTGACTCGGTGCGTTATACTAAGTACCCTTTACTGGTCACAGGCAAAACTGTGATCGGGCGTAGGAACCCGCGTAGTCATCGTCGGCGCAGAAGTTAATTTCTTCATTTGGCGTCGTTTTTTGCCATACCATAAAGACAGGAACTTGTATTTCTTGTCGTCATCTATGGTAGCTCAGGCGGGGCAGGCATTAGCCTGGCCGGTTTCCGATGACGCCGGTATTCCTACCCCCGTCTGGGCTATCACCAATGAGCGTAGGAACTCGGTGATAGCGTTTTTAGTTGTCATCGGAGACCTTTGCTATGTCACCTCAACTGATACAGAAACTCCCGGCCATCACTCTGTTGGAAGGCATGTTTCCCGAGCTATCAACAAACCAGCTTAAAGTCTGCGTTTTTTACGCAATGGGTGTTCCTTACGACGCCATTGCTCAGAACTGTCGGCTTTCTCCCGAAACGGTACGAACCTACCTGAAGCGAAGCCTGAAGAATTTAAATCTGGAAGGATATGATGCACTTCGCTCTGCTGTGCTGATGCGAACTTTCGTTTTCATGATTAGCAATACAGCTAAAGAAAACGAAAAAATGTGAACAGGTGTCCCCATTAAAGGGGACACTTTCATGGAAATTGCATTTTGCACTTTACAGGCGATCCCAAATTGATAAACATAAACACCAAGCACAAGTTACTTTAATAAAGCAAATCACTTCAGACGGTGTCCCAGTTATTTGTATCTGGCTCATGCCCGATATATGGCGATCTTACTCTGAACTGACGTGCTGATGTTTTATTTCGCGTATCACAATACTGTGCCACTGTATTGCTGATATTAGTGCTTAGCCGTTCTTTATCTGTGAGTTCGCCAAATCACCGATACAGAACGTACTAGAGTCTGCTGGTTATATGCCTGTCAGAACTGCAGTTTATCCAGATATGGGCTGGACACTGCTTCAGACATATGATTTAGCATATTCGCCTGACATCGCAAAATCGTCCATCATGGATCGGTTTTGCGCGGAGCGTTGAACTTCGTGAATATAGAACACCTGAATAACCGGAACTGGTATCTTGCGCAATATAATACAGCCGGCAAAAACAGAGAATCTTTATTCTCATGGCTGAATGAGCAAAACGTCGTACCATGGACTCCATTAATAACAAGAAAGATAAGACGGGCAGACTCCAGGCGCTGTTACCGTGAAAGAATATTCGCTATTTTTCCAGGGTACTTTTTTATTCTGGCTAATTTTGACATTCAACCAGTATCGGCATTACGTCGCCATAGCGCCTTCATTGATTTCGTGAAGTTTGGCGGTGAAATAAAACCCGTCAATAAAGATATTGTTGATGGATTAATGAAGATTTACCCGGACCCTGTGCTAAATCCGGGAGCCAGGGAAGAGCTGAATGCGGCTTCCAGCATATGGCTGACAAAAGCACAATATCAGTATCTCCTCAGAATGGAAAATACTCTCCAGCCTGAGTCGAGGATATCCCTGCTCCTGGAACTGGTATCAAATGCCGAACATCACGGCTTTATGGAGCGCCTTGTAAACATCCCATAGCCAGTATTTCCCGGCCTTCGGGCCGGGCTTTTTTCAATTCAGAGAATATTCTGGAGTGAAGCCTGCACGAAGCCATCCCCACCATGGACTCCCCCTGTCTTTTGATGGAATCGTGTATTTCTTAATGGCGAAAGAAATAAAAGGCTTCACCCCAGAGTATTGATTCGTTTTATCAAAGGCCGGCCCGTGCCATCACGTGTGGCGGAGAGAGCGGATACCGGTCTTCTTTTCATCTCACAGTAGGACATTCGCATGACCACGACAGAACATCCCGTGCGCCAGTTGCTCTGGTGTGCACTGAATGCCCTGAAAACGGCACAGGAAAACCACAATATAACCAGTGAAACCGGATTACGGCATTACCTGCTTGAATGGCTTTCTGGTGCCAGCAGACATCCTGAGTTCCGTAGTCTCCCTGGCGAAATCATGGCGTTAAAAGCATTGACCGAAAAAGATCGCAATATTCCCATCATCGGAACGCTGAATACGCTCTTTCTCAGCTCTGCCACTGTCGGGGAATGTCCGTTGTTTCGTTTTCGGGCTGCACTGGGTAAATTACAGAAAGCAGGCTGGCGCACATATGTCTGCCCATGGCCTGAGAGGGTGTTCAATGAATCCATTGAACGGGCCTGTTCCGGGAAACGTCATCTGCTACAACTAAGTCGCACCGAAGAGTGTTTTCTACCGACAGGCGATATGAGGGCACCAGTTACGTTGCAGCTGATCACTCCACTACACCGCAAAACTATGCAGCTTCTGGAAACGGCAGAGTTAATATTCTCCGACGAAGGATTTCAGGTGGTGAGAGGATACGAACATCAATTCGGGATCGAACGCAGAGAAACCCTCTTTCACACCCTATTTATCGGGCTGCCCAGCCTGCCAGAAGATGTCTGGGGTGCAACACAGGAGCAGACGACTATCACATTACACTGAGGATGTGTAATCCCCGGCATACCCCGTTTCCAGTCTTCGCAGCCTGTACCGCCCTTCCTGCCGTTTCCGACATTCTTTCTGTCACTACTCGCTTGTGCCATTTTTTCGCAAGCGGCCCCCATCGACATGACGGTGCGAGTCTTTCTTTTTACCCTGAGAGGAAATTAACAGCATGAAAAAACAACCACTACTCTGGATGACGATAGCCGCCGCACTGCTGTCCGGCTGCACAGGCCACAGGGAACATCACCCGCAGGTGACATTCACGGTCGATACCGTGCGAACAGACACAACGGCCAGCAACCCAATCTGCCTGGCGGAAAAATACGGAAGCCTTCTTAATGAGCGCCATCCGGACCTGTTTGCCGGTGCTCAGGGGAGTATTTCACGCAGTGCATTTTTTAATGGCAGCCTGACGCTGACACCTGAAACGCTCCACGGGATGATACAGAATACGCCCTGTGTTGAATCACTGGTAACGTCCGTAGGTCCGGATACCTTCACTGCAGATGTCTCTCCCGGTGTCAGAATGCAGGTATCACCGGATATTCACGGTGCGCCCGGAAATATCACTCTGCGACTCTCGACCACAGACCAGAAACGAAAACAGACTGTTGAACAAAGCATTTCTCTCAGACCGGAACAGTCCCTTGTCGTGAATGGATTCACCGGAGACGGAGCTGGCGAAAAGCGCGTCGTTCTCATCACACCTCACGTGCGTTAATTCCCAACACAACCCGTTTCCCGTCTTCGCAGCCTGTACCGCCCTTCCTGCCGTTTCCGACATTCTTTCTGTCACTACTCGCTTGTGCCGTTTTTTCGCAACCGGTACGTGCAGTTATGACGGTACAGCTGCTTCTTTTCCCGTTCCGGAAGGAGTCTTTGATGCCACAGCAACATCCCGGACGACTGCAAATACTGGTCGTCGACGCACACTGCAAACGCAGGCTGTTTTCAACGAAAACACCGACAGACCCCGATGAGCTTGCCCGACGTTTCTGCACGCCGGATAACTGTCTCGTGGTGGTACTACGCGACAACCGATTTCTGTTCCGACTGGAGCGTGCTCCCGGCAGCCACTGCCGCTGGCACAAGGGCAGCAGCTCCCGCCATCAGCATCTACAGGACTGGCTGTCGTAAACACAACAAAAACAAAAGACCTCGTCAAAACAGGTGGGGGCCGTGTTCTTTTTAGTTAAATTAACCATCGCGATTGCGATTGTCTGTGTACACCTTTTAACGATTTTAATTTAGCCGTTTGTTGCCATCTTTATTACCTCTCTCCCTTTTATCATGGAGATTAACGATGTTTACCATGTTCTTTCTAGTTAAATTAACCATCGCGATTGTGATTGTCTGTGGAATCCTTTCTCCGATTTTAGTTTCACCACATAACAAACTGTCCACACTTTTTTGGAAGATACCAAACGCGTTCTGGATTTTCCTGATTTGCATATACTTTGCAATCGCCATGGCGGTGTTAATAGAAAGCAGTGAACAGACACGCATCCGCCGCCAACAATATTTCCAACAGTACGAAGTGCCAAATGAGACACATAAAAATGTGGTGATAGAAAACAGTATTAAAAGTCAACTAATATGAAAAATAATAACGTACCATTATATCTATGGTTGCTTTGGTGTACACTTTGTCTGTACATCACTACCCCATGGCAATACTTACGTTATCCATACACTGACAACTTATCATTGCCTTATATGTTATATTTCTGTGTGGTGGTTGTGATTTGCATTTTCCCACTACTTTTCAGATGTGTACTTCTTATTGTAAGGTCTGCATCTAAATACGACTTCACATTCTTTGTGAAGAAGAAAAAGGGAAGCAAGAAATCAACTATACATCTTAGCCCCTATGCTGACACACGTTGCCCGAAGTCAATGAGGAAACACTGGGATGTATTGCTTTCTCTGATATCAAAAGCAATTAATAATGATGAAATCATTGTCATGCATTCACATCTCTTTACTCCAGCAAGAATAAATAAACTTATAAAGAGACTGGAATCTTATGATTTGAGTTTTTCAGTTATTACATACCCACGGAAAACAAGTCTGTACGAAAAATTATCAATTCCTTTTATATATCTCTTGTTTCAGTGGTCTTTCCCGCATTTGCATTCGGACGGAATGACAGTCGTCATTCGTCCTCTCCAGACCCACCACACCAATTAAAAAATACATTTAGATATAAAAAGAATGCTCATAAGCAGGATTTTTATTTTCACAAAAAATCCCAAAACACTGGCTTAATTGGCTATCCACAACCTCACCTTTAAAATAACATGCAACATTAAAATTCAAAAGATAGAATAATGAAAATACTAATCAACAATATTAAAGACCCAAGCAGACTTCTGAATGCGACTAAAACGGGACATTCAGGAGTAATTCTCTCAATACCGGTATACATTACCCATCCAATTGCACATAAAATAATGAACCCTTACTTAAAGTCCGCATTAACTAACAAACACGTATATACGAACACGGAGTCTCCGTTATGAAAAAAAACTATCTGACACTTATACTGCCGTCATTATTGTCCGGCTGTGCCGGAATTTCCGGCGGCAATAACGTGGCACCATCAGATACGCCTGCTCTGGTTTTTGTTGACGGACAAATCAGTGAGAGTGCTGGCGTCCTGGCACTTACGCAACAACGACTTTCTCCACCTAAAATAACTCCGCCCCCGAGAGTCAGCGTGCCAGAGACAGTAAAAACAGCACAGCCAGTAAGCGAATCCCGACCGTTACCTTCACCAACAATAAGTCAGAATTTCTCCCGGTTAATCATTACAGGCAAGCCTGGTAGCACCCCTGTAACACTATCGCCGACGGCCCGTAACCGGACCGTCAGTCAGTGGATAAAAACATTACTACCGGAAGGATGGAAATTCAGACAAGAGAATGCAGCCACGCCCAAACTGAATACCAAACTGGTTTCATGGTCTGCCAATGATCAGTGGACCCGTTCTCTGAACCGGTTGCTGGAAGAACAACACCTCTGGGGCCATCTGGACTGGGATAATAAAACGTTGACCGTCACAACATCGGCTGCTGCACCGGCACAGGACACGGCAACCACTATCTCGCCAGCAGCCATGGTAACCACATCCACTTCCCCGGAGTCTTCAACGACAGCAAATAGCCAGAACAAACCACGAAACCCATTCAGGGGAAACAGCGTATCTCCGTCTACGCCCGCAGCAATCCCGACTCCGACCGGCTCTACAGTCAAGTCTATCCCACTCATGACCGGGACACCTGTCAAACCGGTATCTCAGGGTAAAGAGTGGCGTGCGCCGGCAGGCACTACATTAAGGGAAAACATTATTAAGTGGGCAGAAGAAACAAAATGCGAAAGCATGGCATCAACGCACTGGATGGTCATATGGCCACTTTCTGTAACCGATTACCGTCTTGATGCGCCTTTGATGTTCCGGGGATCATTTGAATCAGCCATGGAGCAGGTATTTGAGTTATATCGGACTGCGCAAAAACCTTTATACGCACAGGCTTCTCGCATGCAGTGCATCATTACAGTTTCTGATACAAGGGATGGTCGCTAATGGGATGGCTGGTCATGGCCGTCGGCCTGACCATTCTGATTATCACTGGTAGCTACCAGAATCAGAAGATGTCTGAAACCACAAACGCCCAGCAATATGCAAGTGCGTCTGTATGGGCAAGTCAGATACTAATGATTGCTAACAGAATCAATGATATCAGATACGTATCAGGCCAGCAGGACGGAGTAATTTCCTCAGATAAACTGGCTCTCCCTGTCACTCCGGACTCCCGAATTAAACATCAGTTACAACAGGGGCGTCTGTGGGTATGGATGCCTGAACAACCAGGACTTGTTGAAACTTTGCGTTTAAAAAGTCGTGGTTCTGCACTAATAGGGATCTTCCAAAACGGGCAACTCACCTGGCTATCAGGAACTGCAACCGGTCTGACACCCCCGGCAGGCATTACTGCTGGTTCTGTCGTCTACGTTAACTAATCTGGATATATTCATGAAAAAATCACACCAGCGTTCAATGAAGCTGGCGGTGCTCCCCTGCATGATCGCCGTCGCTCTTTCCATCTCCGGATGTACTTTCAGCGAAATCAACAAAATGCAGAAAAAAGCACAGGAAGACTCAGCACATGCACGGGAAAAGGTATCAGCCCTTTCGGCCCGTAAATCGCAGGCTCTTACCTGGCTCGATAATCAATGGATAAACCCTGTTCCGGTCGCTCAGGTATCAAGAGAGAAAAAACAAACAGCTCCAGCCTGCTACATCACGCAGGCAAGAAAAGGAGAGATCACTCTGCAGGAACTGGGGCAACGTATTACTGCCGTATGCGGCATCCCTGTGATCATCACGCCTGACGCAGCCAATTCAACTCTTGAAGGAGGCGCTACCCGCCAGATGACAGGAACACTACCAGCACCAGATGAAAATGGACGTCTACCGTTAAGCAGCCTGGGCAGCACAACAATGACTACCTCCACTCAGCCATTAACGCTGAATAACCTCATGTGGCAGGGAGATATCAATGGTCTTCTGGATCTGATGGCCAGCCGGAGTGGTCTGTACTGGCGCATGGATAATGGTCGGATTGTATTCTATCTGACTGAAACCAGAACGTATCCACTTCATATGCTGAACACCAAAACCAGCAGCAGTTCCAGTGTCAGCTCTGGCTCAACAAGCACAATGGGGGCAACAGGAGGCCAGGATAACTCAGCATCCGGTGATGCAACGTCCTCTCAGAGCACAACCGTTGGTCAGGAATACGATCTGTATGAAGATATCCGGAAAACTATTGAAGCAATGCTGACACCAGAAAAAGGCCGTTACTGGTTATCTGCATCGAGCTCAACGCTGACAGTCACTGATACTCCAGCTGTCCAGGAAGCCGTCGCACGATATGTAGACGAACAAAACAGTATTATGAACCGCCAGGTAGCCCTGAACGTACAGGTTCTGAGCGTCAGCAATACCAGAAACGAACAGTTCGGTCTGGACTGGAACCTTGTTTATAAATCGCTACATTCCGCCGGAGCAACGTTGAACAATGCAAGCGGAGATTTTACAGGCGCTACATCTGCAGGCGTATCAATTCTGGATACAGCAACAGGGAATGCCGCCAAATTCAGCGGTTCCAGCCTTCTGATTAAAGCACTGAGTGAACAAGGCGATGTCAGCGTTGTAACTTCACAAGAAAGCACTGTCACAAACCTGACGCCGGTACCTATCCAGATGGCAGATCAGACAGTTTACGTCGCCCAGTCAGCAACAACTACGACTACGGATGTAGGAGCAACAACAACATTAACACCGGGCATGATCACCACTGGATTCAATATGACCCTGCTGCCTTTAATTCAGAAAACAGGCAATCTCCAGTTGCAGATGAACTTTAATCTGTCTGATCCCCCAACTATCCGTAGCTTTACGTCAAAAGACGGAAACAGTTACATCGAAATGCCATATACCAAACTGCGTTCACTGAGCCAGAAGGTCAATCTGAAAGAAGGGCAATCACTTGTCGTTACTGGTTTCGATCAGAACAATACGACGACAAGTAAAGCCGGTACATTTACGCCAGCAAATCCATTATTTGGTGGTTCACAAACCGGGAAAAATGAACGCAGCACGCTTGTGATCATCATTACCCCGACTTTCCCGTCAGGAGGCAATAATGGCTGATGAAGATATCAACCCGGTAGTGCTTCTCGCAGATCCTAAAGTAAATCATCGCGTGTGGGCTGCCTGTCTTAAATGGACTCCTGTCGTAAAAAAACAGCGCGTCCCCTCACATCATAAACACAAGTCTCATGTAAAACCCAGACGGCTTACCTCCCTGAAAGTGACTGTAGGCAGCAGAAATTCCCGTGGAAAGATCAGCCGCCTTACCGGCACAGGAATACTGACCAGGCCAGAACGCAATCATTATTTTTCCCTGGCACTGGCTTTCTGCTCATGGGTCAGAAATGGATACGGTGTCTTCCGGTACAGCGATAAGGAACTCTTATTCCTTGCTTCCATTAATGGCCAGCCTGCCGTTATGGCTGACTTATCAGGAAATGATGCCGATGTTGCCCAAAAGGTCAGCCTTTTTCTGGCGATGAACGAAGAGCCCCCCGAAAAATGGCAGGTTGTATCGTCTCTGGAACATCCTGATAACTGGGAAAGTATTATTACCCGGTTATCATCAGCAGACCTCCGCCGTTGCAAACTTACTGTCGGCAATCGCAGCAAATTCACACTGCCTGCCGTACTGTTTTTAGTAGCAGCCGGCGCAGGCACAGTATTCTGGATGACTCAGCCAGAGCCTGATGTCGGACCGACCGCCGAGGAGATAGCTGCACGGGCAAGATTACAGTTTAAAAAGCCCGAACCACCACCGGAGCTCCCGCATCCATGGGCGTCACAACCTGTAATCAGTGATTTTCTGAAAGCCTGCGCGGACCTTCGAAAACCATCACCGGTCGCGCTAGAAGGCTGGAAACTTACCGGTGGAACATGTACTCCCGAGACATTCACACTGATTTACGAACGACAGCCAGGAGGAACTATTGAAGGCTTTCTGGCAAGAAGCAAAGAAATCTTTAATGTTATTCCTGACTTTAACCTTAAAGATGGTGCACGCTTGGCTTCTGTAACCCGGCTACTGCCTTCCCTGCCCCGCAGGGATGAGGCAGTCCCTGCCCCCTCAGAACAACTGATGCGGGTGTTCACGTGGTTTCAGAAAAAACAGTTAACGCCGGCCATTAATGAAATAGCCATACCGGAACCATTACCAGGTAACGATGGTGAACCAGCCCCTGTTCAGAAATGGAAAGAATATCAGTTCAGTTTATCAACGCCTGTAAATCCTGATGAGTTGTTCCCTTTATTTCAGGATACCGGCGTTCGTCTGAGCAATATCCATTTTGAATTAAACGGCGGTACTTTCAGTTATTCCTCAGAAGGTCATATTTATGCGTCCAGGTAAATCACTCATTATTCCATCCATATTTTTCTTCTCCGGTTTTTCATTTGCAACAACACAACCTCTTGTCACAATAGGAGAACTTGAAGCACAACAAAACCGGAATATTCTTTTACAGGCAAAAGTTCAGGGCGCACAGCTACAGAAACAACTCGAAGAATCAGATGTTAATCTGTCATCTGAAACTGTTTCAGGTTTCTCTGGTATGACTGCCTCTTTGCCATCAGTTTCAGAGCAGCCGACATCTAAAAACAGAAAGGAATTGCCCGTTATTATGGAAATAAACGGCAAAGATAAACGTCTTCATGCCGTTCTTCGCATGGCTGATGGACGTCAGACAAGCGTCACCACTGGTAGCCAGCTTCCGGGTACATCCGTCACGGTGAAGTCGATCTCATTGTCTGGCGTCACGTTAAGTGATGGCACCACCCTTACTTTCTGAGTGATGTGATATGGACAAATATAATTTGAAGGATGCTCTCCTTTTTATATCCCGGGGAGACACCCATGAAATTCTCATCGAAACAAATCAGCGAACAAGACCTGACGTACAGAGTAATCTCCAGGAACTGCTAAACTTATACCCTGACATCATCCCAAAAGTAGTCTCGCTGTCTGAGTTACAGGAAGCCGGTCAGGATGATGAAAATAAAGGTCCGAAAGAACGGATTATTCATCTGAAAGATCTTGCAGATGTCAGTGAAAGTGAGAAGAAAGTTCTCTCCTATTTTGAAACGGCCAGAAAACTTGGTGCTTCAGATATTCATTTTTTAATTTCAGAGTCTATTTTCAAAGTTCGCATGAGAATATTCGGTGAACTGCAAACTGTAGATGAAGATCAACCTGCGTTGGGTTATTCACTTTGCGCAACAGCCATTCTGTCAATGGCTGATGTGACTGAAACCAGTTTCTTCCCTCAAAGGGAACAGGATGCGCGCCTGTCCCCACAATTAATGCGAAAAATAGGAATATTTGGTGCACGATACAGTCACAGACCTACGGGAGATGGTCTGATTGCAGTTATGCGCCTGATACCCGATGACGGAGACAAAGTTCCCACGTTTAAGCAACTGGGCTTTATACCGGAGCAAATCCGGTTGCTGAACGTCATGCTGCGCCGCCCGGAAGGGAAAATAGTTCTGTCTGGTCCAACAGGTTCAGGTAAATCAACAACGTTACGCAGTGCCTGCCGTGTATATCTTGACGATAATCAGGGGCGACACCTGCTGACGATCGAAGATCCGCTGGAAGGACAGATTCTGGGGGCAACACAAACCCCGATTATCTGTGACAAATCCGACGAAGAGGCCGTCAAACTGGCATGGAGTCGTGCTATTTCATCGGCAATGCGACTTGACCCCGATGCCATCATGGAAGGGGAAATGCGCGATCTTGTCTCGATGATGTCAACAACCTACGCGGCTCAGACCGGTCACATCGTTCTGACGACATTACATACAAACTCAGCTCTGGGTATACCGGAGCGGATGATTACGATGGGTATGAATGCCGATCTTATTTGCGATGCGCAATTACTGATTGGGATGATCAGCCAGCGTCTTGTACCAACTCTGTGTCCCTCCTGCCGTATTCCATGGGAAAAGCGAGTACCTGAACTTAGCGAAGACGACCGCGCTTACCTTGAGCGGCACTGCAATAAAGATTCACTCTGCAGTACAGATAATATCTGGTTCCGAAATCCTCACGGATGCTCCGACTGTAATCACGACGTAATTATTAACGGCAGAAAGCGCGGTGAAATAGGTAAAGGCCTCACCGGCAGGACCGTAATTGCTGAAGTGATAGAACCTGATAATCGCTTATTTCAGATTCTGAAAACACGCGGCAAAGTTGCAGCACGTAAATACTGGCTTGAAAACATGCATGGCATCAGTCGTGTGGAGCATCTGCTTCGCCGTATCAATGAAGGCCTGGTGGACCCTCTTGAAGCCGACAGAATCATCCCTCTGGACGAAGACGAACGCCTCAGCATCGATGATGCCTAACAGGAGAACAACATGCGTGAAATGAATTTCAGTCAACGGCTGAGACGTTTCATTGTCAGAAAAACGTTCAGCGCCCCCTACAGGGTGCAGTTTTACGAAGCTCTGCGTTTTCTGCTGGAAAATAAACAGCCATTAAAGACCGCACTGGAACAGATGCGGGATGCCTGGACAGACTTTGGACGAAAATGGCATCCCTTTGCTGAACTGGCCACAGACTGTATTGAGTCTCTTCGTGAAAACAGTGGCGAAAACTCTCTGGAATATACTCTTGGTTTATGGGTTCCCCAGGAAGAGGCTGCAGTAATCAGTGCCGGAATAAGAAGTGGTTCCATTGTGGATGCATTACAATTTGCCACCACACTTACAGATGCCAAAAAGCAACTCCATCAGGCCATATGGCAAATGGCTATTTACCCGGTGGGGTTGTTAATCATGATGACGGGGACATTATATGTTCTTAATACAGAGCTAATACCTGTACTGAGCAAAATAAGCTCCCCTGATTCATGGAGTGGTGCTCTTGGTTTTCTCTATGGATTATCTTTGTTTGTCGATAATTACGGCGCTATATGTGCCGTTCTTTTTGCAGTGGTCACAGGTGTAATATCATGGTCTCTGAAAAACTGGAAAAGCCGCTCTTTGGCTGACAATATAATGCCATGGAGTATTTATAAGGATATACAGGGGGCAGCATTCCTCCTGAATATGGCTGCACTTCTGAAAGCCAAAATGACAACGCTCAACTCACTGAACGTTCTTCAGGACTTTGCATCACCATGGTTAAGCACACGCCTTGACAGCATTATTTACCGCGTACGCCAGGGGGATCACCTTGGGCTGGCTTTGCGTCAGTGCGGTTATCAGTTCCCATCCAGGGAAGCAGCCAACTTCCTGTCTTTATTACAGGGAGATGGCGCAACGGAGCTAATCGGCAATTATGGCCAACGGTGGCTTGTACAAACGCTGGAGCGAGTAAAAAAACGAGCAGCTGTTGTGCGTTTAATTATGCTGATATTTCTTGTCATGTCACTCCTGTTACTGGTCATGGCCGTTGTAGACATTCAGTCTATTGGCGACAACAGTATGGGTAATCTTTAAATAAAACGAGGTATTTATGTTAATCCAAAATATTGATGTTAACGCTCTGAAGAAAAATGAGAAAGAAACGTCTCATGACAAAGGCTGGGGTATTATGGAACAGGGTGCAATAGCACTTGTTGTAATTATCGTACTTGCCCTTGTTTTTGGTGGATTGTATATGTTGCGTTCACGAACCGGTGTGGCAAATGAAAGTTCGAACATACAGACAATCATCACAAGTACTCAGGGGCTGCTAAAAGGTAGCGATGGATATACGTTTACCAGTGGAGCCAAAATGACGGGTGCTCTCATTCAGATGGGTGGCGTACCCAAGACCATGACAGTGCGTGGTACTCCATCATCAGGTACAGCAACGCTCTATAACTCATGGGGCGGTGCCGTAACTGTTGCTCCGGCTTCAACATCAGGTTTCAACAATGGTTTTACCGTCACCTATGAAAAAGTCCCACAGGATGCCTGTATCCAGATTGCCACACAAATCAGTCGTACTGGTTTAACTAACGGTATTACCCTGAACAGTACGACTCACAATGATGGAAAAGTCACTACTGAAGAAGCCAGTGCGCAATGCACAGCTGATAATGGCAGCACCGGTACAAACAAACTAATCTTCACCATCAATGGCTAAGGAGTTTTAATGTCCGGGGGTAAAGTGCCCCTCAGACTTATTTCATTAATCCTGCTTTGTTCTCTTATTTATCCCGCCCGAGCTTCATACATCGCCCCCAAACAAATCTGGACTAACAAGTGGGACAATTGCTTTGCCGCCGCCGGCGCACGCTATCAAATTGAACCATTATTGTTGAAGGCCATTTCTGCCGGGGAATCTTCATTGAAGCCGGGCGCAATTAACATAAATAAGGACAGAAAAACAGGCAAAGCCAGTAGTACGGATTATGGGTTGATGCAAATAAACTCAACCCATATTCCAAAGCTTATAAAGATGGGCGTAATCAAAAAGTCTGAGGATTTAATTACCAAACCATGTCTTAATATCCATATAGGAAGCTGGATACTGGCAAGACATTTTCAGATATGTGGCGTCAGCTGGAATTGCCTTGGATCATACAATGCCGGATTCCGTAAGGACAGACATGAAACAAGAGAGCAATATGCTAATAAAGTATGGAGAATTTATCGTGACATGAAAGGGATATGCCTTCCCGGGCAGGGAGGCAGACAATGCAGACAATCGTAGGCATAAGTCTCTCCCCTGTTTATATCCTCCCATTGATGTTCATATTTTCCATTATTGGACGAACTCTGTTATTCAGAGTTCGTTATTTTTTATCTGATACAGAACATCTCTGGTATAAGACACACACTGCAGTTCTGTCAGGAATATGGCTATATAGTATAGCTGTGGCATTAATTATTTTATCGCCATCCCAACTTCTCTACCGTATTCATGCTGTTCTTATTCTTTCGTTCATGCTGCAAATGGCAGTAACGGATGCACTAACAGGCCTCTTACCTGGTACATTCACCAGGCGTTTTTTAATCGCTGGAATATTATCACAAATCACAACTGATATATGGTGGCTCCGTGCAACAGAAATTGTCTCTGCCGCAATTGTCTTATTCTGTCTGCATAAACTGGTTAACCGCCATCGTCTTAATATTGGCACAGGAGACCTGTGGCTTATTGCAGGTATTACCGCATGGTCAGGGCTATATAACGCCATATGGAGTGTGTTGCTGGGCGCAGGAGGATTTGTCTTATGGCATTCAACATGGTGCATAAAAGGACATAAAGAAGGCCCACTGGGTCCATGGCTGTGTCTTGGCCATGTCCTTTTGCTACTGGATAATCTTTATCAACCACTATGGGTAATCTGATGAAAAAATATGACCGAGGCTGGGCATCGCTGGAAATTGGCGCGGCTTTATTGATTGTTATGATCATAGTTGCCTGGGGTGCAGGCATATGGCAGGACTATTTAAAAACCAAAGGTTGGCAGGCTGAAGCTCGTCTTGTCAGCAACTGGGCCAGTGCAGCCCGCTCTTATATAGGGAAAAACTACACAACTCTCCAGGCCAGTAGTACCACAACAACCCCTGCCGTTATCACGACAACCATGCTGAAAAATACCGGCTTTTTATCCAGCGGCTTTACTGAGACAAACAGCGAGGGGCAGCGGTTACAGGCATATGTAGTTCGAAACACCCAAAACCCGGAATTACTACAGGCAATGGTTGTATCCAGTGGTGGCACCCCTTATCCAGTGAAAGCACTTATCCAGATGGCTAAGGATATTACCACTGGTCTTGGTGGATATATCCAGGACGGCAAAACAGCCACAGGTGCATTACGTTCCTGGTCAGTAGCTTTAAGTAATTATGGTGCCAAAAGCGGTAACGGGCATATTGCCGTACTGTTATCGACAGATGAACTTAGTGGTGCAGCAGAGGACACTGACCGTCTTTACAGATTCCAGGTCAATGGTCGCCCTGACTTAAACAAAATGCACACGGCCATTGATATGGGATCAAATAACCTGAATAACGTTGGGGCAGTAAATGCCCAGACTGGTAATTTCAGCGGCAATGTGAATGGTGTAAATGGCACTTTCAGCGGTCAGGTAAAAGGCAATAGCGGAAACTTTGACGTAAATGTCACCGCTGGCGGTGATATCAGAAGTAATAATGGTTGGTTAATTACTCGTAACAGCAAAGGCTGGCTCAATGAAACTCACGGTGGCGGATTTTATATGTCCGATGGATCATGGGTTCGAAGTGTAAACAACAAGGGCATCTATACCGGCGGTCAGGTGAAAGGCGGTACTGTTCGTGCTGATGGTCGCCTTTATACTGGTGAATACTTACAACTGGAAAGAACTGCCGTTGCTGGCGCATCATGTTCGCCTAACGGCCTTGTAGGCCGCGATAATACAGGGGCAATACTTTCGTGCCAATCCGGTACGTGGAAGACTTCTGGTTCGCTCAATGGTTCTTACACAAACTTAGGTTCACATAGAGGTTCATTCTCAGGGCGGAATTCAGGGGGCAGTACATTGTTTATTTATGCATCTGGAGGTAATGGAGGATCTGCCGGAGGTGCATGTGCAAATACATCCCGACTGCAGGGATATGTTGGTGGGACGCTAATTAGCGTGAATGCCAGCAATAACCCTGCATATGGAAAAACAGCCTTTATCAGCTTTGCTGTACCTGCAGGTACTTCCTATCAGATAACATCCTATCCAACAGAAAATACATCATGTGGTGCCGGGGTATTTTCAGTATTTGGATATCAAACTTAATTGAGCGTTACACACGACGCAATACAACCTGTCTTATGCTCGTATTTGTACCATTTGCGTGAACCTGCTGGGCTCTCAACTACCTGGCAGTAGTGGGCATCCTCTGCGTTGCCCATTCTGGCAATGGCACAGAAGTCGAATTGCCCCAGATAACCTGTGGTGGAAAGCTGAGTAACTTTGAGTTTTCCACCTATTGTCCCCCACGTACCGGATTGGCACTGGCCTACGTGCCAATCCGGTACCTGGGGCGCTCCTAAAATTCAATTCACAACGCAGACCTACAACATAGCTAAAAACACTCGTAATTTAAGGCTCGGGGTCCATGCATATTGCTCATGGACTTACCTGAATGGCTCACCCTTTGGTGGTTTTCAACAGGTATATTCCGACCAAAACAACGTTTGGTATGTGAGTAATTATGCTTGGGGAAATTATGAGTCTGGTGGGACCATATCAGTCACATGCCTCAATCTTCCTGGTGCTGGAGCTTAATTAAAGGGGCAACAGTAGGCATCGACATGTTCCTCATCAACACCATCACCAATACCGTACATGCGTGTTCCAGTCATAATGTATCCAGTCGGACATTGAATCGGCTTGTAATAGATCGAACCACCACTCTTACCGCCGATAAAGTGATTCATTGCTACGGATGATTTGTACCAATTACATGCTGAGTAATTAATTTTATTACCCCCTGACCACCGACCGGATTGGCACTGGCCTACGTGCCAATCCGGTACCTGGAGAAAGGTAGGATCTGGTGAGCTTCAAATTGCTACAGCACAGGCCACAGGTTGGCGCTTTCCTGGAGCAACAGCTACCTGTCCAACTGGAAAACGTGTTACAGGTGGCGGCGGAATATGCACCTCACGAACTGGTTACATATGGCTTACCAGGTCATTCCCATCAGCCAATAACTCATGGTCGGCTGCGTGCGATACAACCGAAGATCAGAATGGTTCAATAACTGTATATGCCATTTGCCAATAAGCTATTTCAAGCAAGTAATCTTCATAAAGTAGGACGAATACTGTGTGTAGTTTTTGGCTTGCCAAGTCATCTCGCCGTTAGAGTCAGGCATGTCAATAGGAATGACTTCTGTTTCTGCCATTTCACGCCCGTCAATACGATAGGTGTTAATACACAGTTTAAACCTCCCTAAGACCTGTGTGTTTTTGGGATATAACGTAAATGTTTTTATATTCGTCCATATCGACGCTGATGATGATTTCCAGGTACCGGATTGGCACGTAGGCCAGCAGCGCCAGCAATTTAATCTCAGTTCTGACACGCGACGACATAACTACATTTTCCGGTTAAATCAGCTCTAAATGTCCCTTTATGGAAATTGTATTCATCATAAAAACCACATTTAACAATTCGATTTGCATCATAAGTTGCAACTGATCCCGCAAAGTAATTCGGCTTCCAGCCTTGAGGGTTTTCTGCATTGCTCACACTCCATGAGCACTGACTGGCAGAAAATCCTGTTGGCAGCGGTATTTGCTGACCATTTGCTATACGACCAGTTATCACCGTACTACCAGAATTGCTTTTACGCCAAGTACCGGATTGGCACGCTTGCAGAGAATGATTGTTGGCATTATTTTTTGCCTCTTTTGAGGTTAGCATGCCGTCTCCACGCATCCGTAAAATGTCCCTGTCACGCGCACTGGATAAGTACCTGAAAACAGTTTCTGTTCACAAGAAAGGGCATCAACAGGAGTTTTACCGGAGCAATGTTATCAAGCGATATCCCATTGCCCTTCGGAATATGGACGAAATAACAACCGTTGATATTGCTACATACAGAGACGTTCGTTTAGCAGAAATCAACCCCCGAACGGGTAAACCCATTACAGGTAATACTGTACGTCTTGAACTCGCCCTTCTGTCATCTCTGTTCAATATTGCTCGTGTTGAATGGGGAACCTGTCGTACTAACCCGGTTGAACTGGTTCGCAAGCCGAAAGTATCCTCGGGACGAGATCGCCGGCTAACGTCTTCAGAAGAACGTCGCCTTTCTCGCTATTTCCGCGAAAAAAATCTGATGTTGTATGTCATTTTCCATCTTGCCCTTGAGACAGCCATGCGGCAGGGCGAAATACTGGCCTTACGTTGGGAGCACATTGATTTGCGCCACGGTGTGGCTCATTTACCTGAAACCAAAAACGGTCACTCACGGGATGTTCCTCTGTCCAGACGTGCCCGTAACTTTCTTCAGATGATGCCCGTTAATCTCCACGGCAATGTTTTTGATTACACCGCATCCGGCTTTAAAAATGCCTGGAGAATAGCCACACAACGACTTCGCATCGAGGACCTGCATTTTCACGATCTACGGCATGAAGCAATAAGCCGCTTCTTCGAACTGGGTAGCCTGAATGTAATGGAGATTGCTGCAATATCAGGACATCGTTCCATGAATATGCTGAAACGGTATACTCATCTTCGTGCATGGCAACTGGTCAGTAAACTTGATGCCCGCCGGCGGCAGACACAAAAAGTGGCAGCATGGTTTGTGCCGTATCCTGCCCATATCACGACCATCAATGAAGAAAATGGGCAGAAAGCGCATCGTATTGAGATCGGTGATTTTGATAACCTTCACGTCACTGCCACAACGAAAGAGGAAGCAGTTCACCGCGCCAGTGAGGTTTTGTTGCGTACACTGGCCATTGCAGCACAGAAAGGCGAACGTGTCCCATCTCCCGGAGCGTTACCTGTTAACGACCCTGACTACATTATGATTTGCCCTCTGAACCCGGGCAGCACCCCGCTGTAAACATCATTCAAAACACATACAGAAAGGCGAGTTGCAACAACTCGCCAAACACATTCGATCTGCATGATCGAAATTATTCGTTTCACCAGAAAAAACACCGAAGATACAATAACCACATGAGCTGAAAAGACTTTTTCAGTCGGAGGAACAATGAGACTGAATACGACCGGTATTGCGGCCCGAATGATGCTCTCGCTGGACAAAAAAGCAATCGGCGAAAAACTCATCAACGGTCGTCAGATAAACCCGACACCTCTGCAGGTCCGTTACCCCCAAGGGGTAAGAGAAGTTCTGGGGATAATGAGCGAACAATTAGCCATATCCACCGCTGATTTAACCCGAATCCTGCTTGAGGATGCTCTTCATAATATGTTTATGCCTGCGGATAACACCACAGGAAACATAATAAGCAGAATTGAATACATCATGCTGTCGCATGATATAAATGCGCCATTACTGGCAACATTGCTGTCGCCATGGAATATCCGCTCCACGGTTATACAGGACCCGGCCAGACTTGCAGACTATCTTTCAGCTGACGCTCTCGAACATCTTGCTGAATGTTTTAATCTCAATCCGGACTGGCTGAATGGCCATGAAAACTATCCGATAGCGTTGTCCGGTGAATGGCCAGATACTGCTGATAATTTCAGAATGCTTATTAATGATAGCAGCAACACTGAAGTTATTTTCTGGCATAGTTTCCCCTTCGCAGGAAACACGAAAAGAGAATATTACGGGGTAATATTGAGACAGAAAAAAGAAATAAATGGTTCTGTAATATATCCGGCACTATCATTATCACCAACAATTCTGAACGATGAAAAAAGAAAATGGTTAACTGAATATACAACCAGGCAGAATACAACAATGTCTTTGCGACGCGTCACGTTGAGACCTGGCCTTGCCGGGAACCTTATTACAGGGCAAATACTACCTGTTAGCTTATTTAATACGTCTTTATTACCCTGGTAAATACCAGATAGTACCAAAGTAAAAAATTACGGCACATCCGTGTCATAGCGTTGTTTTGTCTAAATTCTGATAAACAGGAAATTAAATGATGAAGAAAAATCATATTACCCGCACCATCATTGCATCTGCTGTATTATTTTCCTTTAACGCTGCAGCAGCGACGTCATATTTTGAAGCACGTAACGATGCAATGGGGGGCACCGGGGTAGCATCTTCCCATTATGGTGTGGCACCTCTGGCAAACCCGGCTTTACTGACAAAGCACAACAGCAATGATGATTTCAGCCTTCTTCTGCCGTCTGTTGGGGCACAAGTTGCTGATCCTGATGATGTATCAAATAAAGCTGATGATGTTAAAGATGACTGGGATTTGTTTGATAGTGCTGTTGATAACCAGCATGGCGTACAACAGGCAGCAGCAAATCTTAAACATCGTCTGCAGGAATTCCGCAATATCAATGCAGATGCTCAGGTAGGTGTATCAGCTGTAGCAGCCATGGCAAATGACACTCTGCCGTTTGCCCTTATGGTCAAGTCTTACGGAACTGTCAGCGTAAACGGAAAAGTAAACGATGCAGACCTGGATTATCTGGACAAAGTTGCCAATGGAACAATTACCGACGTCGATAAGAATGCCCTGACCTCACGCGCATTCGGGCGTGCAGCTGTAATTACCGACGTCGGAATTTCATTTGCCAAAGAACTGGAAACGGCCGGACAAAAATGGTCTCTTGGCGTCACACCAAAATATCAGCGTGTGGACCTGTTTAACTACAACGTAACGGTTCGTGATTACGACAAAGACGATTTTGACGGTGACAAGTACCACAACACGAAAAACGGATTCAACGCCGATATTGGTGCTTATACAGACCTGAATGACAACTGGACTGTCGGTCTTGTTGCCCAGAACATCATTCCACGCAGTATTGATACTAAAGTCGTCAATGGCTTTAAAGAAACCTTCAAAGTTCGTCCACAGGCAACCGCCGGTGTATCCTGGCATAATGACCTGTTTACCACTGCTCTTGACGTTGATCTGACTCCTGCCAGTGGCTTCACTTCTGACAGCAAACGTCAGTTTGCAAGTGTTGGTGCTGAATTTAACGCATGGAAATGGGCGCAATTGCGTGCCGGTTATCGTCAGAACATGGCATCAAACTCCGGAAGCGCCTTCACCGCTGGCGTTGGTATCTCTCCATTTGACGTCGTACATATCGATGTTTCCGGCCTGGTAGGAACTGACCACGATTACGGTGCAATGGCACAACTTCAGTTCACTTTCTGATTACTGTCCCCGCCCCCGGCACTAAACCCGGGGGTATTTTTATATTCAGTTTAAATAACATGATGAAACCACGTTCTTCTTATTCAAAAACAGCATTCATTCTTTTATTTTCTGTTTTCCTGGTAGCGGCAGTGACAAAAGCAAAAAGCTCGCTTCCCGATATCACCCTGGAACAGGCAAAAGAAATTAATGCTGATAACACCGTTATTTTCCTTTTCCGCCATGGAGAACGTTGCGACCGTTCAGATATGCCATGCTATTCGGATAAAAGCGGAATCACTATTACCGGTACAGAGAAAGCACAGCAGGAAGGTATTAAGTTCGCAACAATCTTCAGTGAATATGATATTTACTCCAGCAATGCGGTAAGAACCATACAAACTGCAAAATTCTTCTCCGGTAAAGAACCCGTCGTTATGGACAGTTTATCAGACTGCAATAATGATCTTTATAAGACGCTTGAATCAATCGCAAGAGAATCTCATAAAAGGAACATAGTAATAATGACACATAATCATTGTTTATCATTTCTGGCCAGAGATAGGCTCGGCAAGAAATTCAAACCGGCGTACCTTGATGCCCTGATCATGCATTACGATGGTACCCGACTCATACTTGACGGAAAATACAACAAAGAGGCATAGAGGATATTTGAATTTACATAAATTCTGATATACTCAGTAAGATACAAGAGTGTACGGGCACATGTGCCTGTCTGAATTGCAGGTTATCCGGACGAGGGCCGGGAACTGTTTCAGGGACAAGCGCCGGTACGTTCGATTCATAAATCGTCGAGTCATCCATCATGGATCGATTCGGCGCGGAGCGTTAAAGATTACGCTCATGTTCGTTTTATGTCTGACGACACATCAACCAGCCAGTATCAGGAATAATCACCTTCAGTAAACTATGAGGCTATTTACCTGGCCACACTGGCATTTATTTCCGGTAACGCAAGTATAGCCGGAAACAAACATCATCCTGTCTGTACCGGAGCACCGGTATATCCCATTCTGATTTAACTGCTCAGGAATTATTATGAACCGTATTATACCTGCGGGGTGTCTTGCCGCCCTTTTTCTGGCTGGCTGCAACTCCCCTTCTCAGCATACTCCTGTTCCGCGTAACTACGGTGCTGCCTCTGATGTGGCGGTTACCCGGCACACTCAGTACACATTATGGGACAAAGGTGTGTTTTCCGGCCAACTTCCGGTTTCAACGGGGTCTCATCTTCTGACAGCTAACAGCGATCGCCTTTCCTTTGACTGGGAAGGTGATGCAATTGAATTACTGAACGAACTGGCCAGAGTCAGGGGGATGCAGTTTAACTACAATGGTGTCCGCCTGCCGTTACCAGTCAACCTTCACGTCCGGGATATGACGTTTTCCAATACGTTGAGACTTATTGAAGCCCAGACAGCCTGGAGAGCAACAATCCATCAATATCCGGGCTTGTTACAGGTCAGCTTCATGCAGCCGGAGAACCGGAAAAAATGAAAGCACTCACCTCTCTCATTTTGCCAGTAATACTGCTTACTGGTTGTTCTTCTTCCCCTACCATCTCGCCAGGTGGTGTCAATACGCCACCACCTGACATTAATGCATGGCTTAAACCACGAAGTGAAAAGCCGGATAGTCTGTCAGAAACACGCTGGAAAATGCTGACCGACGCAGGTAAAACGCTTGGATTTCGTGGTGGCAAGGCTCAGCGTTCATGGGAGCTGATTCAGGCACTCAACGCCCGGGAAAGCACACTTAATGCCTTATACGATTTCCGGCCACTGATTAGCCCGGAAGGCTGGCTACCACCGGTTATTGATGAAGCACAGGACGTAGCTCATATCACGCCAGATCAAATCCGGACCTCTTCCCGGGTCTGGACCATCATTCGCCCTGAACGCTTTGTCAGCAATCCACCGGGCTGGCGTGACTGGCTTCTCCGGGGGCTTTCAACAACAGCCACTCCGGGTACAGAAGGCAGCGTCGTTCCAGAAGACAGCGTGCAACGAAAAGTGTGGGAAACCGCATTACGGCAGGGATGGCAGGAAGGAAGACAAAACGCCGACCTGACGCTTGAAGCCAACCAGAAAACCCTCACCCGTGATTACCGGGGCATGATGCTGTACTCACTTCTCTGGCGTCAGGGCATGATCACCCGTCCGGATGTTTCTGATCAAATGCAAACCGTTACAGGTGACGGGAAAAAACTGGTCACTGGAGATCGTGTTCGTCGCCTTAAAAATCATGCGGAATTCAATCTTCAGAAATCTCACTGGCGTCCGCTTATAGGCACTGAAGGAGGCTCCCGATGAATATTCCTGATGAGTTTGGTCTTTTTCCGTTTCAGCGTTTCACTGCAGATGAACTACGGCATTTCTTTGTCTGGTGTGCCGCACATAAAGTCAGTGATGTGGATCTGACCGGCGGGTCACCTGTATCTGTCAGTCGCTTTGGCCGACGGGTGCGTTGTTCCAGTGCAACGTTACCAACCACACTCATGTCCTCCCTGATTGATGAACTGTTCGGTCGGGAAGTCATTCCCCGCGTTCTGGCAGGCAATCCGGTTGACAGGACGATACAGATTAACGGGGATGCATCCGGGCGCTATGGTCTTAAACGCGGAGAACGCATCCGGTTACGCTCTCACCTCATTCAGGGCACATCTGGTGCGGAGGAGAAAGCAATCTCAATAACCATGCGTGTCATCCCGACAGAAATACCGGACATTCTCTCCATGAACATTGAACCAGACCTGCTTGAAGCAATGGTCTGCAAAAGCGGTCTGGGATTTGTATGTGGTGAAACCGGGTCAGGAAAATCAACGCTGTGTTCAGCACTGTACCGTTACATTATGGACAATTTCCCCGACGCCAAAATCGTGACATATGAAGACCCGGTGGAATATATCCTGGGAAATGAAAACGATCTGCTCCCACCGCATCAGGCAGAAATCGGGCGTGATGTGGTCAGTTTTGCTGCCGGACTGCGTTCTGCTGTACGACGTAATCCCGAAATTATCGGTGTTGGTGAGATCAGGGATAACGAAACCGCCGACGCAGCGGTACAGGCAGGCAACACCGGACATTACTGCCTGAGCACCATGCATACGAAATCTCCTGGTGAAACGCTGGCACGTCTTCTTGGGCTGTTTCCCCCTGTCATCAGGGATTCGATGGCCTGGGCTGTCCTGTCACTGTTGCAGTTCATTCTGGTTCAGGTTCTGGTCAGAACAAATGACGGTGGTCGTAAAGCCGTCCGGGAATATATCGTCATTAACGATGAGCTTCGCGACAATCTTTCCGGAATGCCACATGCAGAGTGGGGGCATCACATTGATGCCATAATCCGGCAGGAGAAGCGCCGTATCCGGGACCAGATTCTGGAAATGTATATCCGGAATGAAGTTGACCGAAGAGAAGCGATTCTTTTTATCCCGCCAGGGGAGTTACGGTCATGAAAAGAGAAGGTTTCTGGCGATATGCAACACCGCCAGTCAACATCCAGGGCGTACCTCTGCCGTTCACCATGATTTATCTGTTTATATGCCCCTTTCCCTCCAAAACAACCTTCTGGATTTGCACCGGCATCATTTTATTTTTCGTTATTCTCGACCGTTCAGGCTGGACTGTCAGGACGATCTGTACTCGCATTTACAGCATTCTGAGAGGGGCCATCGCCTCCGGTCGTCCATGGTGGTATCGCCACCATACGGAATCACCACGAGACTGGACTGGCCTCGATTAAATTCTGGAGTCTTTATGTCAGGTAAAAAAACTATCGTTACTCTGCTCCGGGTATCGCTACTGGCATGCCCGTTACTGTTCACGACACCATCGTTTGCAATGATCGACACGCCATCCGTGAAGGTCGGCTTTTCTCCTGAAGGAAGCGCATCCGCTCTGGTGCTTGACACAATCAACAGTGCGGAAAGCTCCATCAGGATGATGGCATATTCCTTCACCGACCCGGATGTAATGCATGCGCTGGCAAAAGCGAAAAAACGCGGAGTGGACGTCCGTATTGTTGTTGATGACAAGGGGAATACGAACCGGGCAAGTCAGGAAGCGATGAAATATATCAACCTGCTGGACATTCCTCTCCGGACTGTAGATGCCTTCCCCATCCATCACGACAAAGTCATCATTGTTGACGGAAACACGGTTGAAACCGGCTCCTATAACTTCTCTCGTGCTGCTGCACGCAAGAATTCAGAGAATGTCGTTGTGCTTAAGAATATGCCGGATGTAGCCGCACAATATCTTGAACACTGGCAGGATCGCTGGAATAAGGGTACAGACTGGAGACCCTGACAAACATTTCTCCCCCGATTTTCTATCCCCCCAGCCACCCCCGGCTTCCGGCGGTGGTTTTTTTCCGTCTTTTTTCAGGAGAAGCACTCATGCCGTCTGTATCCCGCTACCGCACCTGGCTTGCCGTGCCTGCAGATGAAATAGAAGATCTCAAAAAAGCACATCCCCCGATGAACGGGCACACGCCCGTCCTCTGGGATAAAGAGCACAAACTCTGGTTTGCCCGCCCGGGGGCGGACCTGTCCATGCTGGACCGCTGGCTGCCCCGACCGCAGGAAGTCTCCATGAACGGCAGTGATCCGGTCACCGAGTTTGCCCAGGTACTGGAAAATGCCGGACTGGTTCTGAAAGAACTGCCGGCCATGGACGGTAAAATCCACCGGGTTCCGACCACCGATGACAAAAACGGGCAAAAAAGTGGCGCATATCGCGGCTTCCTGGACGGCAGACCTGCCGGCTGGTACAGGGATTATCGCAGCGCGGATGATTCGCCGGTCAACTGGACCTTCTCCGGCGGAGAGCAGACAGATCCCCGCGCAAGGCTTCACCTGAAAGCGCATTCGCTGCAACGCAGGGAGGACGCTGAGCGGGAACTGAAAGCACAGTACAACCGACAGGCTGCTTATGCCCGCCGCTATGTCAACAAATGGCCGCAGGCCACGGCACATGAATACCTGACCCGGAAAGGCATTCAGGCTGCGCCGGGGGTGCGAATAAACGACAAAAATGAGCTCGTTATTCCTTTCCGCAACCGTAACGGCGCAATACGCTCCTACCAGCGCATTCCGGTCACCGGCGGGAAGGATGCCCGCATCCTGAAAGATTCCGAGAAAACCGGTAACTGGTTTGCGCTGGGTACACCGCGCAACGGCCAGCCGGTGCTGTTTGCCGAGGGCTATGCCACTGCCGCCTCCCTGCACGAAGCCACCGGCCTTCCGGTGCTGATGACAGTGGATGCGGGCAACATGATTGCCGTGGCCGAAGATGCCCGGCAAAAATGGAAGCAAAGCCCCTTTATCTTCTGTGCCGACAACGATCATGCACGCCAGGTTAACAAAGGTATCGTCAGTGCAACAAAAGCCGCAGAACTGACAGGAGGATCGGTCATCTTTCCTGCGTTCACCGATGCCGAAAAAGCGCAGGGACTGACCGATTTCAATGACCTGGACGCCAGCCGGGGACGGGCCGCTTTTCAGCATGTCATCAACGCCCAGTTAGAACATATCGGGGTTTCCACCCCCAACAGTAACACCCCGGAAATCCGGGAGGCACTGGTGATCGGCAACCTCGTTTTTACACCGGTCCACACTGAGGAAAAAACCATGACTCCGACAGAATATCCTGAAACATCACCCGATACAGGGCACAGCCATGACCAGGGACCTTCTCTGCCGTCCGCCACGCAGCAGGAACAACCAACTGCTTCCAGCAGTAACATTGCTGATGAAACACTGTCATTTACCAGTCACGCCACTGAAAATAACGGCAAAGATGAGCGGCACCCTGATAACGTTCAGGCGCAAACGGAAAGCTCTGTAGTTCAGGACTCCCCTGCAGAATCACCGGCATCCCCGGAAAGTACAACGGCGTCTGCCCCTGATGAACCCGCTCATCCGGCGGAACCTCCGGAAAAAGTTGTCTCTGTGGCCACAGATAAAGACTGGCGTGAATTTGAAGCCGAACTGTCACAACCGGAAAAAAACGAGTTACAACAGGAGTCCGGCACTTCACCAGAAATACCGGCCCCTGCTGCTGCCCCCGCCGCCCCTGAAGACAGCCCCTCATCTGAAACCATGAATGAATCAGCCGAACCATCACCTTCCCCTGATGCAGTCAAAGAGGAAATGACCGTGATGACGGAGCCTGATGACAAACAAAGCACCGGAATATCCCCGGATACTCCCCGGGAAGAGGCGGTCAGCCATGTAACTGAAGACATTCCCCTTCAGCCAGAGCCGTTCCTTCCTGAGTCAGATGGCCCTGAAGAATACGAAGACTACAGCGCATATCAGGAGCTGATGAACAATGAAAATCCTGAGCATCTGCAGGAAAACAGTGATATGCCGTCGCAACCGGACACAGGCCCCGTTCAGGCAGATGAGTCAGAACTTCAGGCCACAACAGCCACTATAGAACCGGCTGTCCGGGATGAACCCACTCCGCAGCAACCTGTTCAGAGCACATCACCTTCTGATAATACTTCATCGTTTCTCGACAAAGCGCGTGGCCTTTTTACGCGTAAAAAAACGGATTCACAGGCGCATGAGAACAGTGATCCCACGCCCTCAGCGGAAACCACGACGACTCCACCGATACCTGACAGTATTGTCTACGCCCCGGAACGTTCTGATGCACCGATATCGCTCAACATGGACGAAATTCTTAAAGAGCTTGACTGGGAAAAACGAGCAGACAGAACCGTCCTGTACAAACTGGATGGCAAACCTGCCTTCATTGACCGGGTAAACCGGCTGGAAATGGTCAACGGTGCCAGCAATGACGATCGCAGCGTTCTGGCCGCACTTGCTGTGGCCACCAAATTTTATGGGGGCGTCATAGAGCTGACGGGCAGTGATGCCTTTAAGCAAAAAGCAATGCAGTTGATTATCGAGCACAACATCGATGTCCGGATGAAATTGCCAGATCAACGGGCTGAACTAGAAAAATTACGCAAGGAAATGGCTGTCAGTAAGGATGCAGTTGTCACCCATCAGCCAACACCGGAACTTAACCGGAATACCCCAGAACAACCGGCTGTCCCTGACCCCGTTCAGGAAAAAGAAGCCACACAATCCCCGGCGTCCCCAGTAGCCCCTGAAGCATCAACCGTCAGCACCGCCTCTGCACCATCACCGGCTGAACCAGGCAAAACGGCAGATGTGGCACCAGACGAAGAACCACCAGGAAAACTTCGCCCGGGAGAGAGCGTGACTGCCGTACTGCACAATTTTGGTCGTGCTGAATATGCACCCGGCAAAGGAGAGAGTTTCTTTGTTGAGCTTAAAAACCGCAGTGGCAGCAAACTCTACTGGGGGGAACAACTGGAAAGTCTGGTCAAAAACCATCAGAAAGGTGACGTGGTGACACTGACACTTCAGAACCGCGAACAATTCATCCTCCCGGGAGAGCAAAAAGCACGTTTCCGGAATAAGTGGTCCATGGAGTCAGTTACCAACGGGATCTCGGTATCACATGATAATCCGGATAAAGGTCAGCGTATTCAGGCGATTCCGGTCGAAACCTTTATGAAAGTGGCTGCGCAAATCAGCCAGGGGTGGCCCGAAGAGATGAAAGCGTTACGTATGCCAGAAAACGTCGGCTCACATCTGTTTATCGGTGAAGACCGACATCCGGTCTCCGCGCCACAGAACGCAAATCAGGTAACAGAAATAACCAGCGCAGCCCCTGACAAGCTGACACCTGTTCTGGGATCAGTGGATAAGGATACGCGTGAACTCAACCTGCTACTTGTCCAGAGTGCCGATGAACATCTGCAGGGTGTGGTCCGGCTGAACGGCACATTGTATCCGGCACTGGCCACCCCATCAGCCGACAACAGTCAGCTGGTTATCAATGCGCTGACCGACAAAGGTTTACGCTTTGCAGGTTATGGTGAAGCGGTAAACCACGATGCTGACAGCACGAATCGCCCTGCACCGGAGCTTATGCAGTTTCATCTGAAAACCCGGGAAGAACCGCTTTTTGCTGCTGTCTACACGCCGGAAAAACAACCTGATGCGTTGTACCGGAACCTGGGCTTCGAGCAGTCATGGCAGCAGTGGTCCAACAGCCAAAAGCCGGAGGACAGGCAGGAAAAAACTCTGCATCAGGATCTCTCCCACAGCCCCGGCCGATGAGCCGGTAAGGAAGCCATATGAACATGCATAAGTCTCTGGTTGCCGTGCTCGGCCTTATCCTGATTTCATCCACGGCAAGTGCTGCAACCTGTCGTGCGGGTAGCGCGGCACAGGCCGGTAGTAATACAGGATATGAGCGAGCACGTGCAGCTGCGGATGCATGGTCACAACGTGAAAACGATGTTTCCTCATCCCTGCAGTCCTGTCTGTCACGAATCAAAAAAATCAGCATAAACCTCCCCCAGTTCCCCAGCCTTGACGACATTCTGTCGCAGCTGGAAAACCAGGTCTGCGACGCGGTCGTGGACAAGGTGAATGAAAAGCTGCCGGGGAATATTGATCCCTGGAAGGACTACAACCTATGACCGAAAATACCGAGCCATCCTCGCCATCACATCCGGCACCTGACCCGGAAATACTGAAGAGCACAATCAGGGCTATGAAGCAGTCAGAACAGCGGGCAAATAATGTCCCTGCGCTGATAAAAGCGCTTTTATGTACGGGCACATGTCTTCTTATCAGTATTACTGGTAACGCCATTCAGTACTGGCACTCAACGAATGTGGAGCGCGAATATTTCGCTACAGACAATGGTCGTCTGGTCAGGCTGGCACCAACAAGTCAGCCAGCATGGAGTCAGAATGATGCAATGGCCTTTGGCAGCCAGGCACTGGCGACCGCATTCAACCTGGATTTTGTGCACTATCGTTCACAGATCTCCTCTCTGTCTCCGCGTTTTTCTGACGAAGGTTTTGCCGGATATGTGAATGCATTACAGGCATCTAACATTCTGGAGACGATCAAGAAAGAGAAGATGAATCTGACCGCCACGACAGGCGCTGGCGTTCTGGTTCGACAGGGACAAATGTCCGACGGCGTATGGTTCTGGACATTTCAGTATCCTGTCCGTATGCGTCTGGTCGGCCAGACAACCAGCAAGCCAGAACAGTCTTTTGTTTTCGAAATCACCATCCAGCGTGTTGACCCCAGACTGAAACCATCCGGTATGGAAATCCGGCAGATGATCTCCCGTAACGCCGGACCGAACTCCTGAGATAAGTAATATGCAATCACGTTATTTACTGAGCACACTGCTCCTGGTGTGCAGCGCCGCCACGTCTGCAGATAACGCAGGATGGCAGAACGCACGCACACCACAAACGACAAATTCTGCCAGCGATCACGTTCAGAACGCCTCCCAAAACACCGGAGGTGTTCCGGCAACACTGGTAAAAGGTGAGCTTCCTGCCCCCGGGCAGGCCAGCCCGCTGGTACAGGATGCGGCAAGACTTGATTCTGAGCTCTCCGCCGATGAGATTCGCTCACTACGCAGTCTCATGGCGGATAACGAGCGGGCCATCAATGCGCCCATCACCAGTGTTGTACCCCGTATCAGCTCTCTGACAGTTAATCTGTCCCCCGGTGCCAGCCTTCCTCTTGTTCGCACAGCCATGAACAACCTGAGCGTAGTGACATTTACCGATATCAACGGTTCACCATGGCCACAATCCGATCCTCCTTATAACGCGGCACCAAAACTCTTTGATGTGCAGTACAACGAGAACATGGTGACAATCACACCATTGCGGCCATGGGCATCCGGAAACATTTCTGTCTACCTGAAAGGTCTGTCGGTACCGGTCATCCTGAACGTAACCAGTGGCGAAACAGATACGCCGTCATCCAGTCAGGAAATGGACAGTCGTCTGGATCTGCGAATACCACGGCAGGGACCAACCAGCCCGGTTGTCTCCATCCCGACGGATAAAATCGCCCTGCATGATGCAACATTACAGGCATTTCTGGATGGTATTCCTCCCCGGGACCCTTCAGTTAAGAGGCTGAAATTCACAGGTAATGTCCCGGATACAACGATCTGGCAACACGGCGATGACCTACTGGTTCGTTCCCGGGCGATGTTGCGCGATGAATTTGAACAGACCTTGTCCTCTGCCGACGGAACTCATCTCTGGAAACTTCCCGTCACCCCACTACTGACTTTCTCTGTGAATGGCCAGTCCGTTCACGTGACACCAGAACTGGAGTAATCATGAGTGCTGAACAGGATGCCGGTAAATCCGGAAAGAAACTGGCTGCCCTGCTTGGACTGGGCAGCATCATCTTATTTGGCGTCGGCTATATCGCGTTTTCCAAAATATCAGGGAGTAACAGCGATATGCAGTCAGCCGTGAACATTAACAGTGCAGCAAGCGGCGGAACGCGCAGCGTTACCGAAACGCCTCACTATCGTGAACTGTTAAGAGCTGATAATGAACGAGGGGCCGCAGCTGCAGCCCGCAATAATCAGACGTTCATTGCCAGTCTTCCACAGGGGCTTGATATTCCGGACACTCCGGAAAAGCAACAACAGCCTGCAGCAAAACCGGAAAACTATGCTCATCGCCAGGCTTCCGGCACACCACAGGAGGATCGAGCAGCCAGTGAAAAACGTATGGAGCGGCTGCAAAAGCTGATTGTAAGAATAAAAGATCAGCATCCTGCCGGTAGTACACCAACCATAGCAACGGCTATGTGGAATAAATCTCCGGCAGAAACAACAGGGCAGAATGGTACGCAGCAATTCGCATTACAGAATGCCAGCCTGTCCACGCCGGTAGCAGAAAAAGGGATACAACTGATACCTGCTCTGACCCGTATACCAGCATATATTGATACGGCAGTGGATTCTGATAACCCGTCATCCAAGGTTATCGCAACCATTCCCGCTGGCCCCTGGGCAGGGGCAACGCTGTTCAGTCCGGGAGTCAAACTGGTGGGTAACGGCGTGGAGATCCATTTCGACCGGATGAGCTGGAACGGCATGGACCTTAAGGTCAATGCATATGCTCAACGGGAAGACAACCTGATGTCATCCGTGGCCAGCAATGTGAATACACGCTGGTTTAAACATATCATTCTGCCGTCAGTGTTAGGAGGTGTGGGCAGTATTGGCACACTTTATAAAGATGCCAACACGCAGGTTATTCAGGGTAACTATGGCACGGTTACCGGACGCGTGGGAATGCCCAGTGGTGAAGCTGTTGCGGGCGTTATTGCCGGTGGTATGGCGGAAAGAGGAAGTCAGATATTAACCCGCCAGGCAGAAAGTGAGCCCTATAAACAGGTAGAAGTGTATCAGCATGAAGTCGTATCAATTCTGTTTGTTGACCCGGTAATGACAAACGACGCCAGGTCATCTTCCCTTTCCAGTGGCATTTCCCCTTCAGTTAATCGTACATCACAGACGGAACAACGCTCGCAGGCACGAATGCAGACAGCCATGGAGCAAAGAAAAGCTGTGATGCAACGTCGGTATGATGAACAACCGGAGACACCATAATGAAACCTGAAACAGAAATAGATGAAACCGGCAGCTTCGGTGAACCCGAAGAGAAACCCGCCCCTTTCTGGAAACGTTCCGTCTGGGGGATATCTGTAGCAACATGGGGGCTATGTGCAGTCGTATTACTCGCAGCCATATGGTATCTGTTCCTGAGAGCACCATCGGAAACAGGCATGCCTCCGTTTAATGATGCGGATGCTGGCGTACAGACCTGGCAAACCACACAAGAATCATCACCTTCCGTTCAGTCCACTGAGACCATGACTGTCCGGACAGGAGAAGATATGAGCCAGCTTGCCCGGGATGTAAAAACAGAGCTGGATAACCGCGATGAAAAAATTCAGGCAACACTGAATATGCTTCACGACAGCATTAACAAGCTGGGCGAAGCTATAAAAAAGGATGAAGAATACGCACAGGAAACGCGCCGTCAGCTGGATGATATCCGGAGCCACCTGAACGGAATGATGACACAGAAAAGCGTCACCGAATCCTCTTCCACACCGCATCCAGCAAAGAAAAAAACGTCGTCTGTACTTAACGGAATGAAAATCATGTCGATGGAAACTGGCATGGCCTGGATTCGCTGGCAGGGTAGTACCTGGGCTGTCAGAGAAGGTCAGACTCTGGGCAATGTGGTGATCCAGCGGATTGATCCGACGACCCGGACCATCATCACCAGTGCAGGGACGTTACGCTGATGAACATGGATGCCCTGACCGCCATTGAGAACTTTGCCAGCAGTATTTTCAGTGCCGGAATGGATTTCCTGTTTACCTGGGGAGAATTCATCGGGGTGATCAGCATGATTACCCTGTTTGCCCGCGCCCGTTCAGCCGGTCCGGTAAAAATGTCTCCCGGAAAATTTATTGCGGGGATGTTAACCAGCTGCATGCTCGTATCACTCCCGGCAATGATTAACGCCGGAGGCGTACAAATGGGATTCAGGGCTGACTCATTTGGCCCGATTGCATATGTACAACCTCAGACGTTTGGCGCTGCTGCTGGCGCAGCAAATGCAGTTCTGTCGCTGGCCAAGCTGGCCGGTGTTGGATTTGTAATGAACGGGATATCCATCTGGCGCAAGGCCGGACTCGATGGACATACCGCACTGAGTGCCAGTGAATCCGTCAGTAAGGGAAACGTCAAATTTATTGCCGGCGTCCTGCTGGTCTTTATCGATCGTGTCCTCAATGCCCTGCTGGCAAGCATTGGAATCGTCTTCTGATTTTTTTCACCTTCATATAAACCACTGATATATCCATTTAAGGAGAAACTATGTCACGTATTCGTGTCGTGGCGGCCCGTCTGTACGCCGCATTTATCCACGCACAACTGTTTGTAATGTCATGCCGGAGCAAACTGACTAAGTTCCTGCTGCTCATTCCCATGATGTTGCTGCCCAAAGCCGTTCTTGCCGATGGAGATCTTGCCGATATGGTTCGCAATGTCGAACAAGGTGCCAAAACAGCACAGTCATCATCACTGACTATTGCGCAGTTCATCGGCGTAATTCTGTTTCTCGGGGGCCTGATTGGCCTGAAAAAAGTTGGGAAACAAGGGGGGATGGGACTGGCTGGTTGCATTGTATCTATCGTCATTGGGGCGCTACTTGTCGCCGGACCTGAAATGATGAGTCGCAGCCAGAAACAGCTGGGGATTTCCACAATTTCCATTGGCTAATCTTGTCCAGGGCACTGGCATTTATCCGGTGCCCTTCCTGTTCGGCAATACAAGGAGGCACATATGTCTGCCTGGAGCCCGGAGCACATAACGTTACGACGAACAGAAAACGGCAATGTGATTGCCCACGACAGTCGGGACGATCAGGAATTCATTTTTGCAGAATGCTGTTCCGATGAAATCGCAAACATCATTCTGGAAGCCGTGAAACGTTACACCAGTACGGAGCCTGCTCATGCAACACAGCATTAAAGACTTGTGGTTGTATCCCTTTCCAGAAATTGATGTGGTTCATACACAGGAGCCACTGTTACCGGAACCGGAATTAACAACGCCCGGTCGATGTATCTGCTGCCGGCAAAACGTCAGGCACCGTTTCAGACTGGATGACTCATGGCCACTCAGACAGCTTACCGACACAATCAGTGACACACGAGTTCGTCTTAATAAGGCCACAGAACATCTGGATAAGTTAAAAAAGCGTGGTGAACCAGTCGCAACCGGCGAAAAGGAAAAGTACAACACGGCAGTAAAAGCCGCTGAACGGGCGCTTGAGCAGGCCCGTCTGTCTGCCAGACGTCTTTCACTCCGCCATGTACAGAAAGCTGAAATCACCAGTACAGAGTCGTTGTCAGAGAAAGAGCAGGAACTGTTTCATGAAGACGGCCCGCCTTACAGCTTATGTGCTTTCTGCCACGCCTGGCATTCACTGAATGGTTATGCCGCAGCACAGGGCGTTATGGTGTGGCTACCCGACCTTCATCCATCCACGGTCGTGGCCCTTAACCGTCGTTCATTACAGGAAGTTTTCAGTAATGATAAGTTCCGGGTCCGGCGGGGACGGGAAGCGCTCTCTGCACTGATGCAAAACAGACTGGCGGTTGAGGATAAATTCCGCAGTTTCCGCCCGGCCGATTTCGCTGACGTTTTTCGTCGCTATCCACCTTCCGGTCGTTCGCCCCTGCGTGAAAAAATGAACGGGATTGCCCTGATTCTGACACCAGATTCATTCATCAAAAAAGAATACGTTGATTGATTTTTCTTCATGCCACTCCAGCGCGGGGTGGCATTAAAAAAATCAAACTGCACAAACCTCCCTCCTGTAAGTCCGGAGTTCCCTCACCTATGAACATAAACCGTTTAATCTTCACTATCGAAGACTGTCTGAACACGCTATCCCGTTTCTCTGTCGCAAGCAGTTTTGTTGAGTATTGCGATTTACGTACTGTAATTGGTCTGGACAGACAGGATCGTGAACGTCGCCCATGGCTGAATTCGCCCTATATTGCAGCCACAAAGCGTGGAGAATATCTCTCTGTCTTTGAAGTCAGCGGTGCTTTCAGGGAAATGGATGAAGCATCCGACCAGACTGGCCCAGGTTCACTGGAATCGCTGATCACCAGCATGAGTGACAGCCTGAATACGGCATATAAAAACAGCGGTCATAAAATCAGCTTCGTTTTTGAGCGTGATCCTGACATGGGGAAAGAAGAAATCGAAGACATGGTCGCCCCACAAAAGCGCTCACTGGCTAATACAGGTATCCAGTTACAGGATGTGGTCGATGAGAAAGTCACAACACTGTCCCCATGGCTGGTCCGGGAGCGTTGCTGGCTGGCGATCTGGAGTGGACCCGACCTTATCAGCAACAGCGATCGCACCGCCCATGATGAGCTTGTCAGAAGACTGGCTGAACGGGTACCGAAAGCACGCTTTGCCCAGTCCCCCTGGCAGTGGACCTTATCTGCACTGAAAATCCGCCACGAAGCTTTTCTTGATAATGTGGAACAGGCACTGAGACATTCATCTGATGGCCTGATTCTCCGGCTACTGGATATACACGAGGTCGGGCGTGAAATACGTCGTCAGACAGAACGGCACAGCACACCGCGTAACTGGCAACCCCACCTGCCTGAAGATGCCCAGCCAGCGGGATATCGCTGGACTGACGATGAATCCGTACTACATGCTCCTTCATTGCATTTGCAGTTATTCAACACTCAGGTGACCACACAGGGCAACCTGGTTCAGGCGGGTGGACTCTGGCACGGAATGGTATCGATTACTTTACCTCCGCAAAATCTGCAGACGTTTAACGAACTGGTCCGTGCCGTCCCCCGCGCAGTCCCCTGGCGCATCAGAATGGATCTGATGCCCGGCGGGATGAAGGCTCTTAATCTGAAGAAAACGCTTCTGACTTACAGCAGCTTCATTTCTGCCGTTCGTCCAATGTATGAATCCGTTATGACCCTGGCGGCAACGGATGAAAAAGAACCTGTCTGCATAATGACCATCATGGCCTCCACGTGGGGAAAAACACGTGAAATATGCACACGAAACGAGGCCATTCTGAAATCGGCCATTGAAGGCTGGGGCGTATGTGGCACCACGACAACATTTGGCGATCCCCGACGCGCCTGGGTGAATACCATTCTCGCGGCATCCGGAGGCTCCGGCCCGGTTCCCCTGTATCCCCCGTTGTCACATGCCATCTCGCTTTTCCCGCTTAACAGGGCAGGCTCTGTCTGGCGAGGCAAAGGGAATCTGATGTTACATACAGAAGACGGTTCCGCATTTGAGGTTGGTCTGGCGTCATCCCAACAAAATAAACATACAGAACTGGCACCAGGCGATCCGGGACTGGGTAAATCAGTTCTGATTAATACGTTGTCGGAAATACAGATATCATCTGCTCAGAAAAACCTGCCCTTCATTGCCTATATCGATAAGGGATACAGTGCTCAGGGACTGGTTCAGCTTATTCGCGACAGTCTTCCTCCGGAAAGAAAAGACGAAGCTGTCGGTATTATTCTGAGCAATGATCCGGAATACACCCGTAACCTTTTTGACGTGATGTACGGCGCTAAAAAGCCTATTACGCCGGAAAAGAATTTCATGTCATCTGTGCTGTGTGCTCTCTGTGTCGATACCGGTACCGGTCAACCCTGTAACCCCGGAGACACCCGACAAATTATCAACCAGCTTATCGAGCTGGCTTTTAAAGAGTACGGTGAAAATAATCCGCGACTTTATCGCGCCTCAACGGAAGAACTGGTGGATTCAGCACTGCAGGACTCGGGACTGTATGAAAAACATGATGCAACCTGGTGGGCCAGATCAACCTGGTTCGAAGTCCGGGATATGCTCCACAATGCCGGGTATATCATGGCGGCTCAGCGGGCACATTATCAGGCAATGCCCCAGCTTCCCGAAGTGTCCTCGATGCTGGGCCATACCAGTCTCAGGGATGTTTTCGGTACTGTTCAGCGTGATGGTTCAAACGAACTTCTGCTGGACTACATCCGCCGCGCTCTCGAGCAGGGACATAACGACTACCCCATGATATCCGGGTATACCCGGTTTATGATCAACCCGGAAACCCGGGTCATCGCTGTCGATCTGAATAATGTTGCCGGTGACAAAACGCCTGCAGGCAGGCTTAAAACCGGCATCATGTACCTGCTTGCAGGTCAGATCGCCGGTGGTGACTTCACCCTGCCACAATACAGGGATGAAGTGTTAAAGCAGCTTCCACGGGAATACCATGAAATCGCTCTTAAACGTATTAACCAACTTGATCAGGAGGTTAAGACAAAAGTTTATGATGAACTGCATAACGCCCGGGGCATTGACTTCATCTGGGAAAATCTGGATACCCAGGAGCGTGAGCAACGCAAGTTTGCTATCCGCACGGTTCTGAGTACGCAGTATCTGAGGGACTACCCGGAAAGCGTTCTTAAGTCAGCAAATACTCTCTGGTTACTGCGCTACAAACCCGAAGATATCCCCGTACTGAGGGATAACTTCAACGTTCCTGAATTTATGCTGAAACGCTTCCTGAAAATGCCGGAAGGCCCGGCACCAGATGGTAGTGGTGTTCCTGTTCTGGGAGTATTCAGGGTAAAAAGTGGCACGCTTGCGAGAATACTCAAATTTACCGTCGGTCCACTGGAGCTATGGGCGCTGAACTCATCGCCAAAAGACAGTGCCCTGCGTAAAACACTGACAAATAAGTTAGGTTCAGTTCGGGCACGTAAGATTCTGGCCGAAAACTTCCCCAGAGGTTCTGCAACGTCATTAATTGAGCACCGGGCGGGCCAACATAACAGTGACAATGTTATTGAAGAACTGGCCTCGGAGCTCATCCGAAAACAGGGATACAATCTCTGATGTGTACAATTCATATCACCCCACGCTGCCGGAGACCTGCCAGAGGGCAGGTATTTCTTAAAAAACTTGAGGTAAAAGGTGACAGTTTCTCATTCACTCTGCCGTCACGTGTCTTCAGGTTACATCCGGCCCCCAATCCCAGAGTGATATACGCCTCGGATGCCAGAACACAGGGAAAGGTCACAGGCATGCGGCTGTTGTTGCCGTCCAGCACAGATGAGCTGATAACAACGGCAATATGGCAGGTTTCTGTCCCGGATGAAGCACCATTCGACGTTCAGCATGTCATCCAGTGGATACTCCCTTCACCGCTGGCTTCGCTGATGTCCGATGATACCTGGTTATGGCCATCCGTTCCCGGAACGCCGGCACTAAGTGCCGGTGACTGGCCTGTTATGGATACTGACCCTTCCACCTTACGGCGCGTCAGACGTCGTTCTTTCAGCATCATCGATAACCGGAACAGGAAAGGTTATATCACCAGGCGATATCAGTGTTTCCCACTGGCCCCACTACCTGAAGACAGAAAATACGACAGCCTTCCTGACCTTGTGCTCCATCCCGAGCAGGAGACAATAAAATGCAAAGAAAAACATTACTCGCAGCCCTTATAGCCACCCTGAGTGGAACGGCATGCCAGGCTCATGCTTATTCAGTCACCGTCGTCGCCAGCCGGCCTGTTGAAGAGCAGGTCATCCCCAGAATGGAAGCCATCAAAGATGTCCTTGGCAACATACTGAGTACCCAGACAGCCACGGGTACCGCTATCAATCAGAACTCTGAAAAGCTGGCAAGTGTCATTGCCCAGAACGGACAGGCGACACGTCAGCAGATGATTTTCAGTAATGAAACTCAGCGCCTCGAGGAGGCACGGAAAAGCTTCACCGTGCCAGACTCCATCTGCAGTGAATCCGCATCAGGGATTGCAACAGAAAGCAAAAGTGCCTCAGCATCCGCAGCCTCAAAACTCAGTAAAGGTGGCGGTGTGAGCAACCGTAGCATCCGCGACCGTCTGGCCAGCGCAGCAAACTCTCCCGTGCGGGAAGCTTATGATGGCGCGGCCATACACGCCAGTTACTGTACAGAAGCAGAATATGCACGTTTTGGAGGAACCGCCGTTTGTCCTTCTGTGGGCGAAATACCAGGTGGAGACAGCCAGGTACGCTCGATTTACCACGGCGCAGGTACAGCGGACACACCTGCGGCACTGACATGGGATCAGAAGCAAATAGATGCAGCGACTGCTTACATGAAAAACACTTCCCGCCCCTCTGCCGGTCGTGCTCTGGGTAAAGGAGAAGTGAATACCCAGAGTGGGCGAACCTACGTCGGACTCCAGAACGAATACAACGGCATCATTGATTCTGCGTCGAATCCCCAACTGACGCTGATTGCTGACAGCACGCCTAATGAAAGCACACGTAAAGCACTGGCTGAAACACTGCAGTCAGACTCAGCGGCCGCTTACTTCGACCAGGTGGCTTCACCAGAAGCAAAAGCACGGGGATATATGAGTACCCGTGAGTTTGAAGCTTTTGAGGCTGGCCGGCGCTACGCCAACACAGCATACCTGGTGGATTTACAGGAAATGCAGGGGGATAACCTGCTCCGTGAACTGGTAAGAATCACTGCGCAAATGAACTGGCAGCTGAACGATCTGAAAGAACAGATCCGCCAGGGTAATGTTATCTCTGGCCAGCAACTGGCTCTGACTGCCCGCCAGTATTATGAAAAACAACTCGGTAGCCTTGAGAAAACAATCAATCAGGCAAACGCACGTTGAAAGCTGACGTCAGAACAGGACTGAAAAAATGAATAAGTTACCGGAAAATTCAGACCAGACGAAAAACGTCAAAAAATCACCATCCATAACCCGCATAGCCACCCGGGGGATTATTAACATTTTTGTTCCTCTGATGGAGACTCGCCTGATAACGAATTCTGTACAGCATATGCTGGAACAACAAAAACGCAGGCTGGACAGATTTCGTCAGGTAAATAATAAAAAGGCGCAACTCCACCTCACGTGGGAAGAAGCTCTGCAGGCCAGCCATATGTCAGTAGACGATCTGGATCGTCGTTTCCGCCGGCGCAGAACAGTATGGCGATTCTGTTGCTGGAGTCTGCTGGCCATCGCTTTGTTTCTCAGTGGTATGCTCTTTGCCGCCTCTTCATTACCTCTTACGACTCTGGTACGCGCCATCAGCACTCTTGTGTTGATACTGTCAGGCGTCGCTCTTTGTGCTTCCAGAGCACTGATTGTTACATACCGCCTCTGGCAGTTGCATGAACGAAAAGTCAGCGAACCCGAGCAGGGGACTTTCCGTGATTTTCTGAACGACCGCAATGGCTGGCGCAATGCCACATTAATTGCCGTAACCAGTAAACAATACTGATCACGTCCAGATGCCAGTACCACTGGCATGTCGCCATCCCCCTTAATTAAATCCTGTGTGGCCTTTGCCCATACGCAATTCTATTCCGGAGTTACTGTGAAAATTTTACTTCGCGCACTCTGTGCAGGCCTTGCTATATCCTCACTGCCGGCAATGGCTTCAGTGACCTATCAGGATATTGTGTCTGCCGCAACCAATCCTGACGATCTGTCCCGTCAGGCGCTGGTCACGATATTCGGTGATGTAGTCACCAATCCACTGTCAACCAGCGCCCCCACTCTGATCGGAAGCATGTTCGGGGCGTTCAACAGTATCATCGCCGTACTTGCCGTTGTCTGGTTTATGTTCATTGGTATCCGTCATGTTGTGCGTTCGGGGCATCAGGGACAGGTATTCAGCACCGGACGCGATATCGTCGGCACACTGAGTGTCGTTGCAGGTTTTCTGATGATCGTTCCAACCGGAAATGGCTGGAGTATCGCTCAGCTCATTATGTTATGGGGCGCATCGATAATGGGGGTTGGGTCCGCCAATGTGATGGTGCAACTTGCCGCTGATAATATCGCAAATGGTTATTCAATGACTGTACAGCCAGTTCAGGCATCCACACGAACAGCAGCGCGTGGCATTTTTGAAATGGAACTGTGTAAGTATGCGGTTAACGCAGGACTAAATGATTTTAATCAGACGGTCAAATCCTCGACTTCACTGATGACAGAATCAGCTAAAACCGCCAGTGGTAATTACACTGTCACGGTATCCAATGGCAGCGGTATCTGTGGTTCAGCCAGCCTGTCAGTAGAAGGAAACGGAACTACAGATCAATCGACGATTGGAAAATTCTTTAATCCCTTCAGTAAAAACGAATACAGCGGTGTTATCTCAGCACAACGTGCAGCCATGGATAATATGATTAGCGACATGGACAACGCTGCCAGTGAGTTTGTGACAACATTTCTGGAAAAAAGAAATTCTGGCAACGGAACATTGCCGGATATCGAGACACGGATTCAGAGAGCAGCCGACGAGTATGAACGCGCTGTACAAAAATCGCTACCTATTGATAACGGAGAACAATCCAGGAAAGAAGCTCTCAAGTCTTATCTCACAACCTATGGATGGGTGACGCTTGGCGCGTGGTATCAGACCTTTGCCACTGCTAACCAGCGTCTGGCAGAGCTGGCTGACAGAGCTCCAGCTGTAACTTCAATGTCATCACTTGGGGAAGTTGGCGATACTGATTTATTTAGTGCTGTTATGGGGGCATACAAGACTCAATTACAGAACTCCACATATACTCCAACGATAGGAACGATAACAACTCAAGATGAAAGTAATGCAGCTAATAGCACAGACCCACAAAGTGTGGTCATGAAAAGTATAGCGCCAACCATATTAAAATGGACAAACCAAGCTGCTACTGAATGGTCAGGAACAGGAACAACCAGCAACCAAGTTAACCCATTAATTAAGATGAAAAACATCGGCGATTATACATTGGGTACAACAGAAATTCTCTGGACAGGATATACAACTGTCAGAGTTCTCGCGACAATGGGTGATAACTCTATTTTCGGAAAGGCTGTTAATTTGTTCTCTGGATTACCTAAAGGATTTGTTGCTCTGCTGGATGCTGCAGCTCCCCCAATATATTTCTTGTTGTTCCTGTTGTTTTGTGCGGGTTTTTCCTTATCAATTTACCTACCATTTATACCATTCATTTTCTGGATGACAGGCATTGGGAACTGGATAGTAAGCGTATTAATAGGATGCACCGCCGGGCCTCTGTGGGCAGCAACACATCTAGGAACATCAGAGGACAGAGGAAGTCGAGCAGCTTACGGATATATATACTTAATTGACAGCATGATAAGACCACCTCTCATGGTATTCGGTTTCTTTTTTGCCTCTGTCGCCATCATTGCCGTCGGCACAATATTAAACTCACTGTTTGGCGCAGCACTAGTTAACGTACAGGTAAAATCATTAACAGGGATATTCAGCCTTGCCGGGTTCCTGCTAATTTACGCCCGTATGTGTACAACGTCTGTAGCTGCAATATTTGCTTTACAAGCATATCTTCCTGACCATGTTATCAATTTCTTGGGTGGTAGAGATGGTGTAAATACTCTTGGCAACCTCACCTCATCAGTAAAAGATATTTTTGCAGGTTCTAATAGAAATATTAGACACAGCCCTGGAGTTAGAGAGGACAGACTAAAAAATGTCACAAAGGATGATAATAAAGATGGAATAAAAGGATAATTTTAATAAAACAACCTTGCCATAAACACTCAATCGCATTAAAATATCGATGAGTGTTTATGGAGGGTTTATTATGCAAATGGTAAAAACAATCAATAGATATCCTGCTTGGTGGACATTATATTACGCCCTTAGATTTATATATTTCATAAGCATACCAGTGTTATCCATTTTTATTCTTTTCGGAGTGCTCTCCATTACATCTTCAAGATATGTGACGCAAGAAGATTATATTTATACTTGCGTCTGTCTGTTTTTACTAATTGCCCCTGCAATATTGATGTATTCCCGAGCAAGCTCAAGAAAAGACAAAATAAAAAAAATTGTCGCGGAGATAAAAAACACCGGTTTTTATTCACCTGACAAAGAATATGAGGGACTGTCTTTTACTCAGGGCGTCTATTTTGGCGTGGATACCAAAAAAGGCACTATGCTGTATGCTCGTGCTTACCCTGGAAATATAATGGATATTATCGGCTTTGACATTGACAACTTCACACGCACTGTGACCGACGCCAAGACACTAGAGATTTATACAAAATACATAAATATACCAATGGTCTCAATTCCGTCAGGATGCATCCATCCCAAAATGATGGCGGATACAATGCATGCAATGGCAGAAAGAGGATATGATTACCCTGTCGACTTTCCTCGCCTAATTCAGGAGAAGCGTAAGGAGTGGGAGCAGATTGCAGGCATGCCTGTAGCCGAAGTATTTTAAGATAAGCTCCCTCCATAACAGCCGGTTCAAATGAGCCGGCTTTTGTTCATTACAACAGATAACTTATGCCGTTACCGATAAATTCGACCAAGTGCTTTAATCGCAGCAATTTTTATTTCCATATCATCACTTTGACTCAATCTATGTAATTCACGAGTAATGTTCTCCGCCTGACACCGGCCTTCACCTAATGCATAGATCGCAGCAAGTGTAACGTCTTTTGATTTACTCTTCATCATTTCAAACAAGAAAGTATTAGCTATCGCAGGAGGCATGCTCATAATCAATCCTCTTCATGAAATAAACAATGGCACTCACTTACAAACAGGAGTCCACTATCGCAAGCGACTCAACTTAGCAATATCTCTCAATTTGAATGAAAAAACCAGATGGCATGTGACAGGGAACCGTCCGCATGATGTCCGTGACCATTTAACCCCATAAGCTAACCTTGTCATAAACGGGCGCAGAACAGCCTGCCAGACAGACAACAAAACAAAAGTCCAAGATAAAACATGAATACCGGTATCTCAATGCGAAGAAATAATCTCCGTAGAAACCCCCATGAGAAAAATATCATATGGGAGAAAATCGCAATTATCACAGCCAGCGCATTCATTATTTTCGCTGTGCTCTGGCATTAATTATTTTCAACACAAAAAGGAAAAAACAATGAATCTGGTAGACGCCTTTGTCAAAAAAGTAATATCCGAGCCATATGAAGAATATGGAAAATGGTGGATAGATGTTGAATACATTTCATGGGGTGTTCCCGGGAAAACAAGACTGATGTTTGAGTCAAAGGAGCAGGCACTGGAAGTTAAAGAAGGGTACAAATTTTTAACGTGAGATCTCTTTTTGTTAAAGGGCAGGAAGCGGTAACTCCCTGCCCTTAGTTACGTTTCCAGGCTTATCAGTCGACAAGTTCCCGGATCAGTTCCAGAACAGCAATCAGCGCGTTTGCAACGGCAACTACTGCCCTGAGAACGATGATTAACAGATTAATCATCCGCTTCTCCATCACTGGAGGAAATCACCGTTGCTTACTCTTACATTGCCTGTCACAACGGCACTTTCAGTGTTAGTTGAAAAGAGACTTCCTCCTGCCAGAGCACTGAACACAGCACCACCTGTTTGTTCAGCCAGGACTTAAAATCTTGCATCCATAGTCCCGATGGATATCACGGCAGAAGTGTCGCCAGACAGAGCTAACCTGCGGATTATAAGGATGGTTGCTATCAAATGAACAGCTCGCTATTATAAGAACGTTAGTTGAAAAGAGATTTCCTCCGGTCAGGGCCACCCACTCTGTAACGGAACAGTAAAAAAACCGACCTCACCAGTCGGTTTTTTTACATCTGTTGTTTCTCAAAATCCGCCCGACATGCCCGTCACACCGGGGAAACTCATGCTCTGAATCAGAACCAATCATCTCAACTTTGCCGTCTCCTGAAAAAACTGGCACATTCAGTTCGATAACTACCCATAAATACAGAGAGAAAATCCGATGTCAGAAAAGTGGAGTAAAGAATTCGACTCTTGCTTTCAGGTGGGGAGCATAGAAGAAATTGCCGATGCTCTCGAGAAACGCAGCGGAAGCGAGGAAAACGCGTTAGCCATGCTGGCAATGACAGCCTTCACACTCATGACCCGACGTGGTATCTGCGAAATGCAGAACGTGGCCCCCGATGGCAAAGGCATTCGGCTGGAGCTAATCGGCTTCAGGGGAAATGAAACAATACCGGATACGCTTCATTGAAGAAGAAAGGGCGCAATGAGGTCAGCCTTCGCAACAAAGCGGCGGCAGAAAACCTGCCGCCGTGTTGCCCGTTAACGTTTAACTTCGTAGGCTAACGTTGCCACAAGCACTGTGTTTCCCTGCTGGAGCCGGAGTACGCAAAGCGAATCCCTCACCATCCAGACAAAACACAGAATCGTCACACAGATGACGATTAACATCATTAAAAACGTTCGCTGTGGCATCATAGCCCCTCCATTGCCTTACGGCGGTTATCGGGCTACTATAATGTTGTCTAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGTATACCGTCCACAAAACGCTTTCGGCATACAGCCTCAAGCGCCCGCAGCTATTCTAACGACTTTCGTATCTGCAACAATCCTTTTATCGCACGGCTAATTCCTCTGGTTAGCTCTTATCGCCTGCAAATAAATTTTTAACCTTTCCGTTTGATTTAAATTCCAGAAATGGAGACTTTGTCATGTCTTACAATCGACAGCCTGTCGCAGAAGATCCTATGCAGATATGGGGCGCTGTTGGTGTCCTTCTTATCCTGCTGCTATTCGTCATATGGTTATTCTTGCCGGAAGTGGTTTACGCCAGCTGCCTGATTCTTCATACCTTATGGGGACTGGTCGACTGGGGACCATTTCATAACTATGCAGCACCACGATACAACCTGCTTGCCATGACCGGTAACAACGCCGCCAACATAAGCTATAGCCAGTGGGTTAACGTCATGGAGCAGACCATAGGTATTCTGTGGATGTACCTCTTACCTGTGACACTCTGGTGTTTGTGGGAATGGTATCAACATCCGGGACAAAGCCGTTTCACCCGCAGACCAGTAGATATTACCCGACTGCCACACATCTTTGCTTCGTTGTCCCCTGCTATCGCCCCTGTACTGGCAGATGGTGATCCGGAAAAACTCTTTCATGGTGGCAAACGACCTGAACGGCGGGTTGCTCTCACCCCGGAAGCATTTGTCGAGCAGCATACTCTCATCACCAATATGCAGCTCGATGTTGCAGCTGCAAGACGATGTTTCATGGCCCAGTTGGGTAAACCTTTAACGTCCTGGAAAGACATGGCACCACATGAAAAAGCGCTCTTTGCCATATTTGGTCTTCAGTATTTCCTGGATGATCGTAAGGCAGCATTAAAGCTCATGGATACACTGAACCTCTCATGCAGAATTAAAAGCAAACGGGACAGTGGGAAATTCTGTACCCCTGTTTATTCACTGGCCAAATCAGCTTTCCAGAGAGTGATTAAAAGCAACGGAGCACAGCAATGGCTGAAACAACATCGCTACGTCCGCAGTGGGCTGGTCTGGCTGTATGCACATGACCTGCGGCTTACGCCACCCAACTGGATTTGGCTGAAAGGCGTGGACAGGACGCTGTTTTATGCATTACACCGCGCCAATACCACGAAAGGATTTATTGAAGGCGCTGGCGTGGTGGCCGTTGCACGTGCAGAGGCCGAAGCCATGCGTTTTGGTCTTCCCTGCCCTGAACCCTGTGTTGATGAAGCGGTGGAAGGCTTACGGCGGGATATGCTCAGTCTCGGTCTTATCTGGGATGAACCACAACCAGATCGCGACCGGAAACGCCGCATCCTGACCAACTGGTCCCTCACCGACGACATCCTGCCCCGCACACCTGCTACAGACAACGAATTCTGATTATCCGGAGAACTGAAAATGACAATCGAGTACTTTGCAACACGCATTGCAAAACATATTTCCGTGCAGGCAATCTGGCCGGATGGCAGGACAGAAATTATTGCCGTCCTTCCACGGGATGCCCTGTCAGGGCTGGTAACACGAAATAATCAACTGATTCATATAGCCTTTGACGCCATGGGCACCCGTAACAGAGAAACCGTCCTGATTGATAAACAGGAGCATAACGCTGACCAGATACTTACAGCTATTGATTCCTGCCTGCGCCTTGAATATCTGATGGAACGCCGCTTCAGCAGAACACCTTTGTTCCGTGGCATAATCGCCAGCGTTGTGCTGTTCGTAATGGCAACGATTGGCTTCTCTCTGTTCCGCTATGTTGATCGTGTATTCTGGGATGATACAACGCCTGAAGCAGTACAGACAGCAGGTGAGCCACGACTGCTACCCCCTCACCTGAATCACACTGTGCCATTAAATGAAGGCATTCAACTCCCGGTTCCCCCGAAAAAAGACGTCCAGGTCCCGGAGAAAACAATCACAAGCAAAAATCCGGAAGCCGCAGCTGCGCGACATAATCTGGCTACTGTTCTGAAGCGGAACGCCGATCGGGGCATGTTTACCATCAACCTGTCATCCGGTCATGAACGAACCCTGTTCGCATTTCTCGATCCTGCCTGTCCTAACTGCAGACTTCTGGAGCCGGCCTTAAAACGCCTGGCCAGCGACTTCAATGTCGTTATCTACCCGGTTTCAGTTATTGGTGGAGAGGAATCCACCGACCGTGTGGCACCACTGCTGTGTGAAAAAGATGCTCAGAAACGTGCTGCCGGCTGGCACCGACTGTATTCCGCAGATAACGGAATGATGACGCCACCAGAAGAAACAACGCCTGCAGATGAAACATGCCTGAAAGCGGCCAGAGCTGCAATTGATGTAAACAATGTCGCCTTCCGTAAGTTCGGATTTGCCGGTACCCCATGGGTGCTGTCCGACACCGGCTGGCATCTGCCTACAGGAATTCTGCAGGAAACTGGCACGCTTAATTTATTCCTGAAAACCACCGACAGCGAGTCTGGCCATGAGTGAACATCGCGTTAACCCCGAGCTTTTACACCGTACAGCCTGGGGAAATCCTGTCTGGAATGCACTCCAGAGTCTCAATATCTATGGCTTTTGCCTGGTGGCAAGTCTTGTGGCCAGTTTTATCTGGCCACTTGCATTACCGGCATGTCTGTTGTTCACACTGATAACAATGCTGGTATTTAGTCTGCAGCGATGGCGCTGCCCTCTTCGTATGCCCATGACGCTGGAATGTGCTGACCCGTCACAGGACAGAATGATTAAAAGAAGTCTTTTCAGCTTCTGGCCAACCCTGTTCCAGTATGAGGTCATTCTGGAATCACCGGCCAGCGGCATATTCTATGTTGGTTATCAACGCGTCAGGGATATTGGCAGGGAGTTATGGCTGAGTATGGACGATCTGACCCGCCATATAATGTTTTTCGCCACCACCGGTGGCGGTAAAACGGAAACCATCTTTGCCTGGGCGATTAACCCACTTTGCTGGGCAAGAGGATTCACCCTTGTCGATGGCAAGGCACAGAATGATACGGCAAGAACGATCTGGTATCTGGCCAGACGCTTTGGACGTGAAGACGATGTGGAAGTCATTAACTTCATGAACGGAGGAAAATCCCGCAGTGAAATCATTCTGAGTGGTGAAAAAACGCGTCCTCAGTCAAATACCTGGAATCCCTTCTGTTACAGCACTGAGGCATTCACAGCGGAGACAATGCAGTCAATGCTGCCCCAGAACGTCCAGGGGGGCGAGTGGCAGTCACGGGCCATTGCCATGAATAAGGCACTGGTATTTGGTACTAAATTCTGGTGTGTGCGCGAAGGCAAAACAATGTCGCTGCAGATGCTCCGTGAACATATGACTCTCGAAGGGATGGCCAGACTTTACTGTCGTGGCCTCGATGATCAGTGGCCGGAAGAAGCTATCGCACCGTTACGTAACTACCTTCAGGACGTTCCCGGTTTCGACCTGTCGCTGGTCAGGACACCATCAGCCTGGACGGAAGAACCCAGAAAACAACATGCTTATCTCTCCGGGCAGTTTTCTGAAACTTTCAGCACATTCACGGAAGCATTCGGGGATATTTTTGCTGAAGATTCCGGTGATATCGATATCCGTGACAGCATTCACAGCGACAGGATTCTGATGGTAATGATCCCCGCTCTGGATACATCAGCGCATACAACGTCTGCTCTTGGACGAATGTTTATCACCCAGAAAAGTATGATTCTCGCCCGTGATTTGGGCTACCGCCTCGAAGGAACTGATTCCGATGCACTGGAAGTCAAAAAATATAAGGGGCGTTTCCCTTATCTGTGTTTCCTTGATGAAGTGGGGGCATACTATACGGACCGTATTGCTGTGGAAGCCACTCAGGTGCGTTCACTGGATTTTGCTCTGATTTTGATGGCACAGGACCAGGAACGTATAGAAGGACAGACAACAGCCACGAATACTGCAACACTGATGCAGAACACGGGGACAAAATTTGCCGGCAGGATTGTCAGCGAGGGCAGTACGGCCAGAACGCTGAAAAGCGCCGCCGGTGAAGAAGCCAGGGCGAGAATGAACAACCTGCAGCGTCAGGACGGCATATTTGGTGAATCATGGATTGACAGCCCACAAATCAGCATCCTGATGGAAAGCAAGATAAATGTTCAGGAGTTGATTGAACTTCATCCTGGCGAATTCTTTTCTATTTTCCGGGGAGAAACCGTACCATCAGCATCATTCTTCATCCCTGACGATGAGAAAAGCTGCAGCAGCGATCCCGTTGTTATAAACAGGTATATCAGCGTGGATGCGCCACGCCTGGACCGTCTCCGCCGTCTTGTTCCCCGTACCACTCAACGTCGAATACCGTCACCGGAAAATGTCAGTGCCATCATTGGCGTCCTGACTGCAAAACCCTCCAGAAAAAGACGAAAAATTCGCACAGAGCCGCACACGATCGTGGATACATTCCAGCAACGCATTGCAGGACGTCAGGCGGCTATGGCAATGCTGGAAGAGTACGACACAGATATCAACGCACGTGAAAGTGCCTTGTGGGAAACAGCGGTGAATACGCTTAAAACGACCACACGGGAAGAGCGACGAATTCGCTATATCACGCTGAACAGACCAGAACTACCTGAAACAAAAGAGGAAAATCAGATATCAGTGAGAGCAGAAAGAGCAGGTATAAACCTGTTAACGCTTCCACAGGACAATAACCACCCGACAGGGCGTCCTGTAAACGGGTTTCATCATAAAAAAACCAACCGTCCGGACTGGGACGGAATGTACTGAACAGTGGCCGCGCCGGATTCTGGCGCGGCCTTTTTTTTAACCTGGAGAAGGCGGTTCCCAGCGTTTATCCTGCTCCGGCGGAGGCAGTGATGCGTCATCGTTGCTGTTCGCCGCGATATAATCGCGGTAGTAGCGTTCACTTCCTTCACGGTGATGATCCACGTCCGGTCGCGTAATCCTGTAGTCTTCGTGACCGGTACGGCCTGTCACATTATGCCAGGCAACCATTTCAGCAAAGACCTGGTTAAATTGTTTGTCGTTTCCTTCTGGTTCAAAACCCATGCGTGGATCACGCCCGAATAATACCGGTGCAATCAAATCCAGTTTATCTGCCAGCGCATTGCGGTCATGGTGATTACGGAAAACAACCCTGTCACCATAATCCGTACAGACAAACTCTCCCGTCCGACGGTCACGGAAACGAACACTCCCGTTCTTCTGCAGACGGGCCTCGAGATCACCGGTATTACCGTATACCGGCGTTCCGCCCGGTTCACAAAGCACGACACAGCGGTCTGTCGTCGTTGTGCGTGACCTGTCTTTACGGCGATCGCGATAATCCCAGCCTCTCAGCTGCGATACAGCAGCCCTGTCTCCCTGAGCAGCCTGAATTTCGACCCACTGACGGTAAGAGGGTGGATACCATTTCCCATCAGCAATAAGTTTCTGTCGCTCATCCCTGATGTCTTCTTTCAGCCTGATCAATGCCTGCATTCGCTGAACTTCTGCAATGTGATAATGCAGCTTACGTAATGCCGGATCATCGTACTGCGCACGAATGTGTGACTTCCGCAGACGGCATGCCTGATGAATTTCCCGACAACGTTCCCCATAACGCAGATCTGGTTTACGCCATTGTTCACGCCATGCCAGATAGCGGGCACGCAGGTCAGCACGGGCCTCAGCTCTGGCTTCACGTCGCTGCCGGCGCAGCATTGGGTCACGTTTACTGCTGACCCCGTACCTGTCACTGACAGCCAGCTCCGGGTTATAGCGACTTTCAGGTTGCACCCTGTCAAACAAATCTGCTGGGGCACTCACAAAAGGTCCGGCCTGTGGCTCTGCACGCCCCAGTGTCAGATCAGGATGAATGCTGCTGGCCTTCACCGGCGTTTGCTCATGATTAAAGGCATCAACGACAACAAGCCCGTGATGTTGTTTCTGTAGCATCAGTCCCTGTTGTGCAAACAGCTCATGACAACGCTGCCAGGTAAACTCACCCTGTGTGATCATTTCTTCAATCTGAGGGCTACAATGGCTGATGCTGTATCCCCACAGACTTTCTTTGTCAGAAAACAGTTCGCGTTTGATAGCCCCCTGCGGCCCCGTGCCTGTACGCATACGGTGCCATTCTTTATCGGTCGCAGGACAGCTCTCCATACGACGACCACGGAAGCGTTCTGTTGGCGTAACCTGGCGGAAAATATCTGTTGGTACAGGCTGCCAGCCACCATCGAGTTGATTCACATTGTCGAGCGTCAGCAGCGACCATACGCTGTCAGCACGAACGGGAGTCTGGTTATGATCATAACCGTCACAGATAACCAGGTGACCATGCTGAACACGCATCCATAATCCCGCTTCAGCCAGTGTGCGGTGAATAGCCTGGCAGTTTTCCAGCCGTCCTTCCCGTGCCATTTCCGGCAGACGTTCTCCAAGATGACGACAGGCATACTGCTGCAGACTTTCTGTTTCAGCGATTTTTTCCGGGCGAACATCAGCGGCAATGAAGTCCGGATTATAGCGTCCTGGTGCTTCCACCTGGCTGAAAATGTCTTTTGGTACTGGCGTGTAGTCACCCATTTTTTTCATGAGTTTTTCTGCACACCAGGAGGGACCAAACGAGTCAAGCTGTACACCTTCCCTGTTGCGATCCCAGCCATCCATCACCAGAAATTTTCCGTCCATCTGAGACAGGTACAGACCATCTTCCGCAAGACGACGATGCAGGGATAACCAATCATTTACAGGTTCACTGCGTAAACCAGCGACCGCTGTCTGCGCGACATACTCGCGAAAAGTTTGTTTTTTTCCGCGTGTCCAAGCGTTCTGGCGATCACGTTCAACGGCAGTTTTGCGAACGATACGATTTCCCGGCGCATGGACCCAGCAACCGTTATCCGGAGCAAAACCATGCTTCAGTTCAAGCTCACGGCAGGCACGGCTGAGTTTTTCCTGACTCCATGAAAGGCAATTGAGATAACCTGTAACCGGATGTACCCGGTTGACCGCAACGTGAACATGCAGGTTATCAGTATCGGTATGTACGGCAGAAACATACTGATGTTCACCCAGCCCGAGGGATTTCAGGGTATGGCGTACACTGTCATAAATCTGTTCCGGACGCGGGCTTTCATGGGCCTGCCAGGAAAGAATGTAGTGAAAAACAGGATCAGTATTATCTTTCGCATAGTGTGCCTGCTGTGCAATGTACTCCATATCTGCAGCGGCAGTTTCAAGAGATGTACAGTTGTGAAAACAGGTCACACCATAAAAGTTAACCCATTCGCAGCCGTCCTTCATGACATCAACCAGCGCCACGAATGACTCATTTCGAAGACGTGTCGCATAATCAACAAGGCGACTGAAACGGCTTCGGTGCGGTTGTTCAGCCTGCGAAGAAGAAGATAAATCCAGTTCCTCATCGGTCATGTCATCCCGGACAGAGACGTAGGATACCAGGTCTTCGAACGAAGACTTGCCGTCCCTTCTCTTTTTCGGAATGACTGCATTCACCGGAGAATCCTCAACCTTCCATTAACTGTTTACGCAATGTATTTGTAAGTTCGGTTATGGCAACAAGTACTTCTGCGTATTCCTTGTCACCGGTTCTTTTTCCCTGAACAAACAGATGCTTCTGCATCCTTCCCAGTCTCATTAACTCCTTCAGAAAAGCATCATCTGTACGGGAGTTAATTCGCTTATTCAGTGCTGCATTTCGGATGTAAGCAGATACAGTAAGTCCGGAATCTTCAGCTTTTTTCCTGATGGTTTCATCCTCAACAGGAGAGAATCTGAGTGTCCTGACAACTGTCTTTTGCCGTACCTCACTTTTCTTTCTTACCGCACTATCACTCACTTCAGGCTCCTTACGGGGTGTCGGGGCGAAGCCCTGACCAGATGGTAATTGTAATAGCGTCGCGTGTGACGGTATTACAATTACACATCCTGTCCCGTTTTTCAGGCCATTATAGCCTGTTATTTTTGTGCATCATAGTCTTATGCAGACGGCAGAGGCAGGGCGCAGCCCTGCCAGGAGTCAGTTTTTGATGATAAAATCAGACTTCAACATGAAACGGAGAGAAAGTGCCAATGGCTTCTAAAAAATTTTACTCAGATGATGACATCCAGCTGGCAAAAGCTGCTTTATCGGAATTGCCAGATCTCACCGCTCAACGGAAAACATTGCGTGATTTTCTTGATGCCATTCGTGATGACATTATTGTCCTGGTAAGGACAAAGGGTTATACACTGGCAGATGTTCGTGACACGCTCAAAAATGCAGGGTATGAAGTAGGAGAGAAGGCACTTCGTGACATTATTCGGGAAGCAGAATCGAAAAAACCATCCCGCCGTTCTTCCTCTAAAACAGCACCTAAAAAGACAGATTCAGGCAGGAAAGATGGCATCGATATGAACAACAATTGATGTGACAATGTCACATCGTGTTCTGAGATTATGATGATTACAGAAAAAAAAGCCCCGGCATAAATACCAGGGCTTTTCTGTTTAATCAGACTCGTGGCGGCAATGCACCTGGATAATGCCGTGCAATAATATCATTCAGTTTTTCAACAAGGTCAGAACGCTTAAAGACAATGTGTACGGTCCCTTTCTGGTAGCCACGCACCGTAAAATATTCCCCTTCTAACAGCTTACCGACATTGTCGCCGTTCCCGAGAAATTCACCATACTGCGCCCCGATACTGTTCCTGAAGTCAGGAACGTTGCGCCCCTCCAGCAGATAAAACGGACGTACCAGGTCATCCAGTGCCTCCCGTCCGCTGCAGTCCAGCGTCACACGCCCGTTACTCCAGCGGTACAGCAGGTTTTCAATAATGATTTTCTTACCCAGACGGCAGGGATTATTGGTTCTGTAATCCCATGACAATTTCCGGTAGACATCAATCAGTCCCTGTTCAAATGTCTGCATCTTGCAGGCATTCAGATGGCGGAATGTTGCCAGTACATTGTCCAGGGTGATTTCAGGACAGGTGTCGCTCATCAGCTGGCTGTTCCACTCATCACGCTGGCATGAACTCATGAAGGTGTACATGCCCGTATCTGTCATCAGGCGGTCCCAGATTTTCCGGTCGGCAAGACGGGTGATATTCCTTTTCGCTTCTTCCGGTTTATCTATGCGACGAACGGAATCAGTCACGCAGTCTTCAAACCCGTAAAGAAAAATATCACCTGACGCATCGAGCAGAATCTTGCGCGCTGTCGCCAGGCATTCCATCGCCTGCATGAACAGTGCAATACCTTCGTTACGCTGCGCGATGATGCGGTCGATAGCCACAGACGGAATAACATCTGTCGTGCCGGCAGTATTCAGGTCAGCAGTGGGTAAAGTCTGATTCATCACATTGTCTCCTCATCGTCACGACTGCCGGGACAGCCAGGTCATTTCCCGGAGGAGCGAAGCTCCTTCTGCCGTCCGGGTCTTCGGGGATTTCCCCGCAGTGGACCTTTCCGACGGGGGACGCTCACCACGTCACGGGGCAGTTGTCCGGGGGCAGACGCAAAAGTTTTTGACGCCTGCGGCAAAAAGTTTTGTGGCTGGTACATCTCTCCCCTGGACGACTGAAACGGGATGTGGTCATGTATGTACCCCCGGAAAGTCCGTCTGCGGAGAACAGGCCGCAGTGCGGCGGCAGACAGGCAGAGACAGCTGCGCCATCAGGCGCAGTGGCCTTACACACCGTAAGGTGTGCAGGGAGCGCCGCATACGGCGCGACTGAAGAAAAACGACGGCACAACAATGGCATGTGGTGGTCACTGGCACACCACTCCCGCACAGGTGAAAACAGAGAAAACCGCACGACATTTACAAGCAAAAAAAGTGAAATTTCTTCACTTTTTTACACTTATTTATCGCGCTGATTTGGCAATTGTGATGATAAAATAAAGTGAAGTTTTTTCACTTTTTCAAAGGTGTTTTATGACCGGCTGGGAACTGCGAATCTGGCGAAAAAGCATGCTCTGGTCACGCGAAAAAGCGGCCAGAGAATTTGGCGTGACGCAGAGAACATGGCACGCCTGGGAAAATGCGGAACAGGTGGACGTCACCGTCTGGAGGACCACCCAGGCACTTTCAGTCCGTGACCTGCTGCCTCACATGCAGGGGATGCGTAAGGCAGATATCATCAGGCGACTGGAAAATGAACTGGGGGAAACGGCAGAGGATGTGTGAGCGTGATTCACAGCCTGGCTGAATGCCAGGCTACTGCTCATCAGGAAACAGCTTTTTCAGTTCTTCACCGGAAAGTCCGGTTGCCTCCTGAATCCGTTCCGGCGTCCAGCCCATATCCCGCAGCCGGCAGGCTATTTCCCGCGCCACTTCAAGTGCGCCTTTTTGAATAAGACGTTCTGCAATCGTCATGCTGTTTGCTCTGCTCCTGCTGACAAAAAAGCCCGGCATTTTGCCGGGCTGTGATGTTTACTCAGTGAGTGATTTTCTTCAGTTCGTCATCGGAAAGTCCGGTAGCCTGCTTAATCTGCTCCGGCGTCATCCCCATTTTCTGAAGCTGGCACGCAATAGCCAGGGCTTTTTCAAGCGCTCCTTCCATGCGTCCTTCCATCCTGCCTTCCTGGCGACCTTTTTGCTCAAGACGTTCTGCGATAGTCATCAGTTTATCCTCATGCTGCGGCAGACGCTCAGCCAGCGCCCGCATAAATTCCGGTGATACAGAGTCCCCTGCGTTAACGATGTAATGAATCAGAACACGCACCTGCTCGTCTGAAATTTCCACCATGACCTGCGGGAGTTTGTCCAGCAGCTCCATCATGTCACGATGGCGGATATGCTTCATCAGCAGCGTCAGTGCGGCCATCCGGCGATGGTTCATGATTTCATTGTCATCAACGACAGTGATATCAACCAGCGGAAACGGCTTTGTGTATATTTTAGCCGCAAGCGCCGGATTCTCAAAACAGTCCAGCCAGTTCATGCTGTACGGGTACGGGCTGCGCTCACCGTGATAGAACAGCACCGGAATGACCAGTGGCAACGTTTTGTGCTGCTCCAGATGTCTCTGCATCGCCGCCACACTGTAACGTAACATGCGGAAAGGCATGTACAGATTTTCGGTGCTCTGGTGCTCGATGAGCGTATAAACATAGCCATCTTCACCCCCGGTGGTTTTCACACTCCAGAGGATATCGCTGGCGTACTGATGCAGGTCCGGCTCAACAAAGGTGGCGGGTTCCAGCTTCAGCGTGGACAGGTCGCACAACTGCCGGTACTCCGCCGGAAGATGCAGTTCCAGAAAATCTCTGGCGACGTCGGGATTCGCCAGGAACGACCGGAACGCGGCATCATGCGGCGTGGGCGTCGTGGTGGTTTTCTTCTTACTCACGGTTCCTCCTGGTGAGATGTCTGAACGTATCCTGCCGCCTGCACAGGCAGACGGCAAGGGTTAATCAGTGGCAGACCCGCTCAATTTCAAGCGCGCGGAGCAGGTGGCCCCATTCGCTGACTTTCATAGCGGGGATACGCACCCGCTTCTGCTCACTGCAGCGTCTGGCGATATGGCCGCTCATCGCCAGGACGTCCGGGTTAATCTCATCCTGTGCCAGCTCCTGACGTCTGAAGCGGGTATGGCGGTGCAGGGGTTTATTCTCCCGCAGGCACTCTTCACGCAGACGCTTTACATACTCGGCGGTTGCGAAGATAATTGATGGTCTCATGGCATAATCTCCATAGATAGTGATTGAGATGCCGGACTTCCTGGCGGGGAAGCGCCGGCGGAGAGAGGCAGGGTTTATCGCCCTGCCTTTTTTTCATTTCGGACAGCGACGCAGTGCCAGCGCGAGCGCTTTCATCTTCCAGCCTTCCGGCGTGCGGTACATCACCTTCCAGTAGCCGTCGATGAACACATAATGGAAGCGCACCTCTTCAGTGCTTTCAGTGGCAATAGCCTCCCTGAAAGAACGGTACTCACGCGCCTCACTGTCCATCCGGAAACCACTGTCACGTCCGTAATAAGCCGTCACACCGTCCACCGGGTTCTGAAGCGTATGCCCGGCGGGTTTGTCGCAACGGGGACCGAGGCAACGGATATCACCGTGTTCAACCAGGGCTTCGGCCTGCTGACCGGTGGCATAGTGGGTATGCAGGATGCGACCGTTCCAGGTCGGCTCCCCGTGCAGGTGGCAGTAAACGGTACGGAACACCCCGTCGCGGCAAAAAACGGAAATCGTGCTGCTGACTGTCATGAAAACGTCTCCTTCTGCTGAATCAGGTCGCCGGGCCGACCGGTTGCTCCCCGGAGGGGCGAAAGCCCCTTCTGCCGTCCACTTCTTCGGGGTTTCTCCCCGCAGTGGACCTTTCCGATGGGGCGTCCGTCACCACGTCACGGGGCAGCTGTCCGGGGGCGGACGCAAAATTTTTTGCCGGGTTTATGGCTAAAAATTTTGTGGACGGTATATCTTCCCCTGGACTGCTGAAACGGGATGTGGTTACTCCAGCCCCCGGAAAGTCCACAGCGGGAAACAGGCCGCAGGGGTGGCGGCGGAAGGGTTGACTGCGCCATCAGGCGCAGTGGCCTTACACACCGTCAGGTGTGCAGGGAGCGCCGTTTCCGGCGCGACAGGGGCGGCGCGACCGGAACGGTCGCTGCAAGCCTGGTTTTTCAGACATCGGACCGTAGCGGCAGCCCGAAACCGCGCCAGCGGGTTCGGCGGAGACTGGCGGGTGCGCCAGCAGCTGCCTGTCGGAGTCGGGCCTGACGACCGGATGCCGCCAGGCAGCCGGGAGCCGAAGGTGTCCCCGCCTCCGGAAATCAGAACAACAGAAACGACATAACAGAAAAATGCCTCACACCATGACGGGCAGGAAGGGCAGCGCCGCAGGCGCGGCCCTCCTGCATTTCAGGCAGGCGTAAGCCTGCCAGGGTTTTCCGGCGGCCTGGCAGGCCATACCCCCGCCGGAGCGGGGGAGTAAATCACCGACGGAACACATGACCGTCAATAAAGGTGAAGGAGTCCAGGAATAAATCCCGCGCATACGCCTCATAGTCAAAATAGAGCGCCACCGTCTCCGGCACGTCAGCCAGCAGGCCGGTATCACTGGCGAACTCAACCGCAAAAGCCTCCTCACTGTCAGCCTCGCCCCACCAGGCATCGCGGAAGGTGTCAAAATCCGTCTCACCGGTATCCTCCACCCAGAGACGATAAGCCTCTTCGCAGCCTTCATCCCGTGCCAGGCGGAAGCCTTCAACCCAGGCCCAGTTGATATGGCATTCAGAGGCCATATTCCCCGGGAATCCCTCATAATCCTGAAACATCAGTTCAGGATCGGCTTCATCCTGGTGAAGAGCACGGCAGGCGGCGAAAAAGTCGCGCTCATCATCAAACGTGGTCAGGTCAAACCAGCGTCCGGCGATGCTTCCACAGTTGTATTTGTGCCAGGTTCCAACGTATACAGCAGGTGCAACAACAGACATTCCCGAATCCTCCATAGTCACATGTTCTGCGACACCGGGCGGTGCCGTGCCTCCATAAAAGCCGGGCGATAAGGCGGGGATGCAGGGGCGCAAGGGAAGCCGCAGCCTGACGCACACGGCTGACGGGAGTTGCAGGGTGAGGCCGCGAAACCTGAGCGGACGAACGACCGGAAAATCACGGCAGACGGGAAGGAGGGACCGGGTGACCGCAGCGGCGAAGCGTACCCTTGCATCCCTGCCAGCCCGGCTAAGATGGAGGCACGGCACAGCCCGCACACGACGCTGAGGCCACAGAGCTGAAACCCCACAAGGCCATGCCCCGCATGGCCGGGTAAAAGCGGAGCCGCCGGCGACTTCCTTATTCCGGCGAGTGCAGAGGACACGCCGCATGACCTCCAGACCACCCCTGATATGAAACGATCATGATCGGCGTGTCCCTGCGTAAAATATACATGCCTGGTTCACCGGAGAATATCTGTGATATCCACAAGTTTTCTGTCGCGCAGCCAGTCCTGCGCTTCACGCACCACACAACTGTCCGGTTTCACCGCTTTCAGCGATGATGCCAGTCGCTTGATCAACATCACCAGTTCCCGTGTCTGTATGTCCGGCATTGTCTCCGGCGGAGCAGGGGGACTCTCATTTCCGACGCTCATCCCATGCGCTTCCAGTGTGGCACGGACAAACCAGGCGGCATCGACCAGTTGCTGTCCAATCCAGGCCAGATCGGCATTTCTGTCACGGGCTGCCATTCGCTCGCCCGACAGCGCCTTGCTGATATGGCTGCGCACCAGATTATCCAGGAGTGCCTGCGCTTCTTCCGGTGAAAAGCCACCTGGTATCTCTGTGCGCAACAGCCCTTTCCTGTACAGAAGCTGCAGCAGATCAACCTGCGACCGCACAGCAACTATCAGTACATAACGGACAACATTCGCACTGGCAGTGGTTTCTGTATCATTCAGCAGTTCTTCCGGATCGTTCCCCCCGGTGTTGCAGAGCAACGGCAACAGAGGTCGCATCCACGCGGGAACCTGGTATTTTTCGTCTGATTTCATCATATTACGTTCTCCAGCTTGTTCGGGATCATCCACTGCTCAAGTGCACGTACCTGTACCGGTGCACCACGACCGGCCTCACCGGCTTCAAAAATCAGCCGCCAGAGTGGTTCCTCCTGCCAGAAAAACCGGTCAAATGATGACAGTGATGGAAAACGCCCGCACCACCCCCAGAAAATCGTTTCCAGATCATGCTCCTCAACAACACCAGACCAGCGGGACAACCAGCTTCCGACCGTGGCGGGAGTATGAAACGCAAGGTCAATCTGCGCCTGAGCAAAACATGTCTGGTATTCCAGTTCCCGTCGTTCTGCCTCACGTTCCCGCTGGCGGCTGTATTTCTGCTCTGTCAGCGTGGTTTTCTGACGACGACGCTCACCTTCACGAAAAGGCACGGACGGGAACAGACGGTGCCCCGCATCGGATGGCAGGGGAAGAACACAGACTTCCCCAAAACTTTCAATCAGTTTATCCACGGCAGCCAGCCACAGGAGACGGTTGCCATGAAATTCCTCCTTCGTCAGCGCAGGGGCAAAAAAGCGGAGATCGGTCAGCGAAATCCGGCGACTGCCATTCAGGCAGCGAAAGAAAGCGGTGGCATAAGGCCATGCTGAAAGTGTGCGTCCCTGACGACGACGTTGTTCTGTGACAGCCACCGCCTGCATGGCGGCCTGTTGTTCTGCGCTGAGGGGGATCAGTGCCCGTGAACGTGCGCTCATGCCTGACCTCCTTCTGCCATCAGGATATGGATGATGTCGTTAACACTGTATCCCTGCGCATCCAGTGTCGCGGCAAGCGCCAGCGTGTGACTGATCGCGGCAGGCGTGAAGATATGTTGCACCTGAACGACGGCGAAAGGCTGTCCACCACCATTCACCAGAACCAGCATCCAGAGCTGAGAGACGTCTCCCGGCGAACATAATGCCAGGTGGAAACGTTCGTGGGCTGGCGTGAAACGAACCTGGACGGGGAAAAAGCCCCCGAACTCGCTGCCATACTCTCCGTTCATCATCCAGTTAGCCGGTGCGTCCACTTTACGCATCACCTCGTGAGTGAGATTACGGCGCATATCGCTTCCCGCAGCACGGATTTCTTCATATTCCTGGGCATTCATGGACTGCAGGGCATTCAGTGTCAGTTCGGTATTCATCATCGTATTTCTCCCTCTGCCGCCCCGTCTCCGGCGGGGCGGTGTGGTTGTTCATCAGGCGGCATCAGCCAGGTTATCGGCGCGTTCAGTGGCATCCGTCTGTGGACGTGGTGAACACATCCAGCCAGGCACCCAGCGGTTGTCTTTCATATGGAACTCTGCATGTTCAGCGGCATCGCCTTTCTTCATCTTCTCTGCGTCCCGTGCGGCACCGGACAGTCCGGCATCATTCAGGGCTGCGATAATCTGCGGCTTTTTCAGGTGTCCGAAGAAGTTTGCTTTCGTCGGCTGCCACCAGTCGCGCATGTGAAAACCGATGGCGCTCTCCAGTGAGTCAAGCGGACTGCGTGACGTGCGACCACACTCGCGGGTCTGGACACCGTTAAGGCTGCATGCGGTGCAGAAACTGAGCAGGGATAACAGCACCTCCTGACTGAGTGACAGGAACGTCGTCATGTCCCGTGACCATCCCTCCGGTAACAGGGCCGCAAGACGGGCTTTTTCTGCCATCAGCGCCAGGAATGCGGCACCTTCCTTCCCTGACGGCGCATCGCTGGTCAGCGAATAATGTTTACATTCCAGGCTGATTTGTGCTGGTTTACTGTACGCTCCGCTGTCAAACACATTCAGGCAGAGCGTCCATGCCAGCAGTGCCAGAGATTTGTCCGGTTGCTGCATCAGTGCTGCCTGGACTGCCAGCGTGCGTTCGGAAGACATTTTCGTCAGCAACGGCAGACTGATTTCCTCCACTGACGCTTTCTCCTGCACCTGTTCCGTGCGGTCAGCGTCATCAGTCGCGTCATCTTCACTGCGCAACTGCACACCACGCTGGACACATACGTTTCCATAACGCCAGGACACCACCACGCCACTTCCGGCACGCATCTCCGGCGTCCACGCCCTGACCTTCGCCATGCAGCGCATCAGCTTCATTTCTGCTTCCAGCAGGTCGGATTCCTCACACTGGTTTTCCAGCGCGTCGTAACGCGTCATCAGTTCGTTCAGGCGTTCTTCTTCTGCCTCCGTCAGCACCGCTTCCGGCTCCGGCAGACAGCGGTATGTTCCGGCATCCTCACGGCACTCACCGACAGGCTCCATGCGTCCGGCGCACCATTCCCAGCCTTCGGCTTCCCGAAGGTGTTCAGCGACAGCCTGGAGTTTTTCCAGCAGGGCAGCATCGAGCGCCACGCGGTCGACATAACCGTCCCCGTCATCGCTGAACAAATCAGTACGCAGTTCGTCAGGTGAGAAAGCATCAGCCCCCACGAAGCGGAATTTACTGTTACCTGCCACCGCCACTTCACTTTCGGTCACCAGACGACGAATGGTCTGTACTTCCGGTTTACCGCCCCATCCCGACTGGCAGGCGGCTTCAAACACCTGCACCTGACGCGCGGTGTCGTTCTCCAGCGCCAGCGCCTGACAGTGCTCTGTGGTGATGCGGTCTTCTGCCAGCGCATCGAGGATGACAGGCGCAAGGTCTGCCAGTTTCAGCATTCGCTGAACGTGGCGGGGCGAATAGCCCAGCAAATCACCGATTTGTGCAGGCGTTTTGCCTTCCTGCGCCATCGCACGGAATCCGGCAATCTGTTCGGCAGGGTGCATATCCCGACGATGACCGTTTTCAGTCATTGATGCAGCCGTCGCCAGCTCCTGCGGAATAACCTTCACGCGTACAGGCCAGTCAGCCGGAATGATGCCACGCTCTGCCAGCATGTTGAGTGCAGCCAGTCGGCGACCACCTGCGGCGACACCGTAACGGTCACCAGGCAGGGTATGCACGACCAGATTCTGCAGCAGTCCGACGCCCTTAATGGACTCCGCCAGTTCGCTGACGGACTCCGCAGAATACGGCACCGTGCGCACATTCAGCGGTGATTTAATCAGCGAGGCCAGCGGCACGCTCACTTCCTCCGTCTGCGCCAGCAGGGCAGACAGGACAGTTTCCTGCGTTTTTACAGATTTACGGCTTGCTTTGCGGGTGGTTTCTGGTTCACACTTCGTTACAGGCATAATCATCCCCTTATAATTGCTTATGTCCTGCCGGACGTTCGCGCGTCCGGCACCTCTCTTACTTAAGAATCCCGAAATCCCTGATGTACTGGTTCATCCAGTACCCGGCACAGTCCTCAAAATTCCAGGAGCGCCAGATCAACGTGCCATCCTGACGGACAACCAGGCGAAAATGCGTTCCCTGATCATCCTCGATAAAGACGTTCCGGTACTGTGCGGCAACGGCTTCCGCCTGTTCGCGGGTAAAGGAGCCGTCCGGCAGTCCCTGAAGTATTCTGAAATATTCGCTCATCCTCATATCTCCGGTGATGCCCCGCACAGGGCGGGGCGGTTGTCACAGTCAGCCCGATCAGAACGGGATGTCGTCTGAAAACCCGTAATCCTCCCCCTCCGGCGGTTGCGGCTGAGGCTCTGGCTGCGCGGCCTTACGTCCACGGCCTTTCGTTTTCGCGCCACCTTTTTTCGTCGCGTCAGCACTCTGTGGCTGCCCATTCTGCTGAGGCTTCGGTTGCGCCTGAGCGTTCTGCTGTGGTGCACGTCCCAGCATCTGCACGGTGCCCGTGGTCTTAACAAGAATTTCAGTGACGTAACGGGTGATACCGTTATCTTCCCAGCTACGGGTGCGAAGCTGACCTTCGATGTAGACCTGCGCACCCTTGCACAGATATTCACCTGCCACTTCCGCGAGCTTGCCGAACAGCACCACGCGGTGCCATTCCGTCTGCTCCCGCATCTCCCCCGTCTGTTTGTCACGCCAGCTTTCTGATGTGGCCACCTGCAGGTTTGCCACTGCGCCCCCGTTGGGGATGTAACGGACTTCCGGATCATTGCCCAGACGCCCGACGAGGATGACCTTGTTGATACCACGTGCACTCATAAGAACCTCCTGACTGAAAGATGTGAGATAAACCGGATACCGGCGACGGGACGTTCATGTGCCCCTTCAGAGGAGCGAAAGCTCCTCCTGCCGTCCACTTCACAGGGGTTTCTCCCCGCAGTGGACCTTTCCGATGGGGGCCCGTTTACCGCCTCACGGGACAGCTGTCCGGGGGCGGACGCAAAATTTTTAGCCGGGTTCATGGCTAAAAATTTTGTGGCCGGTGCATCTCACCCTGGACAGATGGAACGGGAGGGGGTTACGTCTGCCCCCCGGAAAGTCCACAGCGGGAAACAGGCCGCAGGGGTGGCGGCAGGAGGGAAGACTGCTGCGCCATCAGGCGCAGTTTCCTCACACACCGTCAGGTGTGCAGGGAGCGCAGGTCACGGCGCGACAGGGGCGGCGCGACCGGAACGGTCGCTGCAAGCCGGGTTTTCACG
--- a/tool_data_table_conf.xml.sample Tue Nov 05 16:46:20 2019 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,8 +0,0 @@ -<?xml version="1.0"?> -<tables> - <!-- Locations of MOB-Suite database in the required format --> - <table name="mob_suite_databases" comment_char="#"> - <columns>value, name, path</columns> - <file path="tool-data/mob_suite_databases.loc" /> - </table> -</tables> \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/workflows/AMRworkflow_STARAMR.ga Thu Nov 14 00:43:21 2019 +0000 @@ -0,0 +1,184 @@ +{ + "a_galaxy_workflow": "true", + "annotation": "Mobilome and resistome analyses are valuable tools to better characterize genome assemblies for the presence of antibiotic resistance phenotypes and mobile elements such as plasmids. The location of the resistance (chromosome or plasmid) will provide information on potential dissemination potential of the antibiotic resistance genes via horizontal or clonal gene transfer mechanisms (available via the summary.tsv report). This draft workflow will help end-user to potentially qualitatively estimate potential AMR risk for a given isolate along with the underlying mechanisms and the epidemiology of antimicrobial resistance. \n\nPlease provide us with your feedback in order to improve usability and flexibility of the workflow. For more information refer to http://dx.doi.org/10.1099/mgen.0.000206 and https://github.com/phac-nml/staramr. \n\n", + "format-version": "0.1", + "name": "Mobilome and Resistome Analysis Workflow (MOB-Recon and STARAMR)", + "steps": { + "0": { + "annotation": "", + "content_id": "toolshed.g2.bx.psu.edu/repos/nml/mob_suite/mob_recon/1.4.8", + "errors": null, + "id": 0, + "input_connections": {}, + "inputs": [ + { + "description": "runtime parameter for tool MOB-Recon", + "name": "input" + } + ], + "label": null, + "name": "MOB-Recon", + "outputs": [ + { + "name": "seqhits", + "type": "input" + }, + { + "name": "outfile1", + "type": "tabular" + }, + { + "name": "outfile2", + "type": "tabular" + }, + { + "name": "outfile3", + "type": "tabular" + } + ], + "position": { + "left": 200, + "top": 200 + }, + "post_job_actions": { + "HideDatasetActionoutfile1": { + "action_arguments": {}, + "action_type": "HideDatasetAction", + "output_name": "outfile1" + }, + "HideDatasetActionoutfile2": { + "action_arguments": {}, + "action_type": "HideDatasetAction", + "output_name": "outfile2" + }, + "HideDatasetActionoutfile3": { + "action_arguments": {}, + "action_type": "HideDatasetAction", + "output_name": "outfile3" + } + }, + "tool_id": "toolshed.g2.bx.psu.edu/repos/nml/mob_suite/mob_recon/1.4.8", + "tool_shed_repository": { + "changeset_revision": "2c7f721a4905", + "name": "mob_suite", + "owner": "nml", + "tool_shed": "toolshed.g2.bx.psu.edu" + }, + "tool_state": "{\"adv_param\": \"{\\\"min_length_condition\\\": {\\\"min_length_param\\\": \\\"False\\\", \\\"__current_case__\\\": 1}, \\\"min_con_ident\\\": \\\"80\\\", \\\"min_mob_ident\\\": \\\"80\\\", \\\"min_mob_evalue\\\": \\\"1e-05\\\", \\\"min_rep_evalue\\\": \\\"1e-05\\\", \\\"unicycler_contigs\\\": \\\"True\\\", \\\"min_rep_ident\\\": \\\"80\\\", \\\"min_rpp_evalue\\\": \\\"1e-05\\\", \\\"min_rpp_ident\\\": \\\"80\\\", \\\"run_circlator\\\": \\\"True\\\", \\\"min_con_evalue\\\": \\\"1e-05\\\"}\", \"input\": \"{\\\"__class__\\\": \\\"RuntimeValue\\\"}\", \"__rerun_remap_job_id__\": null, \"chromInfo\": \"\\\"/galaxy/tool-data/shared/ucsc/chrom/?.len\\\"\", \"__page__\": null}", + "tool_version": "1.4.8", + "type": "tool", + "uuid": "017d5861-8836-46a8-8444-0dcaca60eda1", + "workflow_outputs": [ + { + "label": null, + "output_name": "seqhits", + "uuid": "6304bc2b-bcc9-47c4-8e3b-9d2ee5a80433" + } + ] + }, + "1": { + "annotation": "", + "content_id": "toolshed.g2.bx.psu.edu/repos/nml/staramr/staramr_search/0.2.2", + "errors": null, + "id": 1, + "input_connections": { + "genomes": { + "id": 0, + "output_name": "seqhits" + } + }, + "inputs": [ + { + "description": "runtime parameter for tool staramr", + "name": "genomes" + } + ], + "label": null, + "name": "staramr", + "outputs": [ + { + "name": "blast_hits", + "type": "input" + }, + { + "name": "summary", + "type": "tabular" + }, + { + "name": "resfinder", + "type": "tabular" + }, + { + "name": "pointfinder", + "type": "tabular" + }, + { + "name": "settings", + "type": "txt" + }, + { + "name": "excel", + "type": "xlsx" + } + ], + "position": { + "left": 420, + "top": 200 + }, + "post_job_actions": { + "HideDatasetActionpointfinder": { + "action_arguments": {}, + "action_type": "HideDatasetAction", + "output_name": "pointfinder" + }, + "HideDatasetActionsettings": { + "action_arguments": {}, + "action_type": "HideDatasetAction", + "output_name": "settings" + } + }, + "tool_id": "toolshed.g2.bx.psu.edu/repos/nml/staramr/staramr_search/0.2.2", + "tool_shed_repository": { + "changeset_revision": "9047a1d3d8ea", + "name": "staramr", + "owner": "nml", + "tool_shed": "toolshed.g2.bx.psu.edu" + }, + "tool_state": "{\"__page__\": null, \"use_pointfinder\": \"{\\\"enable\\\": \\\"false\\\", \\\"__current_case__\\\": 1}\", \"__rerun_remap_job_id__\": null, \"genomes\": \"{\\\"__class__\\\": \\\"RuntimeValue\\\"}\", \"chromInfo\": \"\\\"/galaxy/tool-data/shared/ucsc/chrom/?.len\\\"\", \"advanced\": \"{\\\"pid_threshold\\\": \\\"98.0\\\", \\\"exclude_resistance_phenotypes\\\": \\\"false\\\", \\\"exclude_negatives\\\": \\\"false\\\", \\\"plength_resfinder\\\": \\\"60.0\\\", \\\"plength_pointfinder\\\": \\\"95.0\\\", \\\"report_all_blast\\\": \\\"false\\\"}\"}", + "tool_version": "0.2.2", + "type": "tool", + "uuid": "41f8718f-87a0-45d2-b79d-e5afddea1532", + "workflow_outputs": [ + { + "label": null, + "output_name": "blast_hits", + "uuid": "9e8592ad-71c0-4528-8e8b-efcd3bb9183a" + }, + { + "label": null, + "output_name": "resfinder", + "uuid": "2f27a46b-29bf-4abf-9d26-fce4e9fc9dd5" + }, + { + "label": null, + "output_name": "excel", + "uuid": "67549d0b-0480-4c25-8bfd-1fa78cfdb066" + }, + { + "label": null, + "output_name": "summary", + "uuid": "17c9e48c-234a-4cb7-986d-f88166bfe0a7" + } + ] + } + }, + "tags": [ + "AMR", + "Resistance", + "ResFinder", + "StarAMR", + "MOB-Suite", + "ARGs" + ], + "uuid": "d6ce87c0-2d16-4c8c-bea8-6464264565d4" +} \ No newline at end of file