Mercurial > repos > iuc > gemini
diff gemini_comp_hets.xml @ 17:65f742e605ec draft
planemo upload for repository https://github.com/galaxyproject/tools-iuc/tree/master/tools/gemini commit 344140b8df53b8b7024618bb04594607a045c03a
| author | iuc |
|---|---|
| date | Mon, 04 May 2015 22:46:38 -0400 |
| parents | 53a5647e5271 |
| children |
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--- a/gemini_comp_hets.xml Tue Apr 28 22:55:56 2015 -0400 +++ b/gemini_comp_hets.xml Mon May 04 22:46:38 2015 -0400 @@ -1,11 +1,12 @@ <tool id="gemini_@BINARY@" name="GEMINI @BINARY@" version="@VERSION@.0"> <description>Identifying potential compound heterozygotes</description> - <expand macro="requirements" /> - <expand macro="version_command" /> <macros> <import>gemini_macros.xml</import> <token name="@BINARY@">comp_hets</token> </macros> + <expand macro="requirements" /> + <expand macro="stdio" /> + <expand macro="version_command" /> <command> <![CDATA[ gemini @BINARY@ @@ -23,14 +24,13 @@ > "${ outfile }" ]]> </command> - <expand macro="stdio" /> <inputs> <expand macro="infile" /> <expand macro="add_header_column" /> <expand macro="column_filter" /> - <param name="only_affected" type="boolean" truevalue="--only-affected" falsevalue="" checked="False" + <param name="only_affected" type="boolean" truevalue="--only-affected" falsevalue="" checked="False" label="Report solely those compund heterozygotes impacted a sample labeled as affected" help="(--only-affected)"/> - <param name="ignore_phasing" type="boolean" truevalue="--ignore-phasing" falsevalue="" checked="False" + <param name="ignore_phasing" type="boolean" truevalue="--ignore-phasing" falsevalue="" checked="False" label="Ignore phasing when screening for compound hets" help="Candidates are inherently putative. (--ignore-phasing)"/> <expand macro="filter" /> </inputs> @@ -44,13 +44,13 @@ <help> **What it does** -Many recessive disorders are caused by compound heterozygotes. Unlike canonical recessive sites where the same recessive allele is -inherited from both parents at the _same_ site in the gene, compound heterozygotes occur when the individual’s phenotype is caused +Many recessive disorders are caused by compound heterozygotes. Unlike canonical recessive sites where the same recessive allele is +inherited from both parents at the _same_ site in the gene, compound heterozygotes occur when the individual’s phenotype is caused by two heterozygous recessive alleles at _different_ sites in a particular gene. -So basically, we are looking for two (typically loss-of-function (LoF)) heterozygous variants impacting the same gene at different loci. -The complicating factor is that this is _recessive_ and as such, we must also require that the consequential alleles at each heterozygous -site were inherited on different chromosomes (one from each parent). As such, in order to use this tool, we require that all variants are phased. +So basically, we are looking for two (typically loss-of-function (LoF)) heterozygous variants impacting the same gene at different loci. +The complicating factor is that this is _recessive_ and as such, we must also require that the consequential alleles at each heterozygous +site were inherited on different chromosomes (one from each parent). As such, in order to use this tool, we require that all variants are phased. Once this has been done, the comp_hets tool will provide a report of candidate compound heterozygotes for each sample/gene.
