# HG changeset patch # User greg # Date 1504615447 14400 # Node ID ff4d84a01fa71e2d32be0afc91dd3f9c05d7552b # Parent 7d9af0d824ad93f3054fa6265f7b05e30e16065a Uploaded diff -r 7d9af0d824ad -r ff4d84a01fa7 ideas.xml --- a/ideas.xml Tue Sep 05 08:38:49 2017 -0400 +++ b/ideas.xml Tue Sep 05 08:44:07 2017 -0400 @@ -237,13 +237,13 @@ **What it does** -IDEAS (an **I**ntegrative and **D**iscriminative **E**pigenome **A**nnotation **S**ystem) identifies de novo -regulatory functions from epigenetic data in multiple cell types jointly. It is a full probabilistic model -defined on all data, and it combines signals across both the genome and cell types to boost power. The underlying -assumption of IDEAS is that, because all cell types share the same underlying DNA sequences, **functions of each -DNA segment should be correlated**. Also, cell type specific regulation is locus-dependent, and thus IDEAS uses -local epigenetic landscape to **identify de novo and local cell type clusters** without assuming or requiring a -known global cell type relationship. +IDEAS (an **I**\ ntegrative and **D**\ iscriminative **E**\ pigenome **A**\ nnotation **S**\ ystem) identifies +de novo regulatory functions from epigenetic data in multiple cell types jointly. It is a full probabilistic +model defined on all data, and it combines signals across both the genome and cell types to boost power. The +underlying assumption of IDEAS is that, because all cell types share the same underlying DNA sequences, +**functions of each DNA segment should be correlated**. Also, cell type specific regulation is locus-dependent, +and thus IDEAS uses local epigenetic landscape to **identify de novo and local cell type clusters** without +assuming or requiring a known global cell type relationship. IDEAS takes as input a list of epigenetic data sets (histones, chromatin accessibility, CpG methylation, TFs, etc) or any other whole-genome data sets (e.g., scores). Currently the supported data formats include BigWig and BAM.