Mercurial > repos > aaronquinlan > multi_intersect
diff BEDTools-Version-2.14.3/src/closestBed/closestMain.cpp @ 0:dfcd8b6c1bda
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author | aaronquinlan |
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date | Thu, 03 Nov 2011 10:25:04 -0400 |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/BEDTools-Version-2.14.3/src/closestBed/closestMain.cpp Thu Nov 03 10:25:04 2011 -0400 @@ -0,0 +1,202 @@ +/***************************************************************************** + closestMain.cpp + + (c) 2009 - Aaron Quinlan + Hall Laboratory + Department of Biochemistry and Molecular Genetics + University of Virginia + aaronquinlan@gmail.com + + Licenced under the GNU General Public License 2.0 license. +******************************************************************************/ +#include "closestBed.h" +#include "version.h" + +using namespace std; + +// define our program name +#define PROGRAM_NAME "closestBed" + +// define our parameter checking macro +#define PARAMETER_CHECK(param, paramLen, actualLen) (strncmp(argv[i], param, min(actualLen, paramLen))== 0) && (actualLen == paramLen) + +// function declarations +void ShowHelp(void); + +int main(int argc, char* argv[]) { + + // our configuration variables + bool showHelp = false; + + // input files + string bedAFile; + string bedBFile; + string tieMode = "all"; + string strandedDistMode = ""; + + bool haveBedA = false; + bool haveBedB = false; + bool haveTieMode = false; + bool sameStrand = false; + bool diffStrand = false; + bool ignoreOverlaps = false; + bool reportDistance = false; + bool signDistance = false; + bool haveStrandedDistMode = false; + + + // check to see if we should print out some help + if(argc <= 1) showHelp = true; + + for(int i = 1; i < argc; i++) { + int parameterLength = (int)strlen(argv[i]); + + if( (PARAMETER_CHECK("-h", 2, parameterLength)) || + (PARAMETER_CHECK("--help", 5, parameterLength))) { + showHelp = true; + } + } + + if(showHelp) ShowHelp(); + + // do some parsing (all of these parameters require 2 strings) + for(int i = 1; i < argc; i++) { + + int parameterLength = (int)strlen(argv[i]); + + if(PARAMETER_CHECK("-a", 2, parameterLength)) { + if ((i+1) < argc) { + haveBedA = true; + bedAFile = argv[i + 1]; + i++; + } + } + else if(PARAMETER_CHECK("-b", 2, parameterLength)) { + if ((i+1) < argc) { + haveBedB = true; + bedBFile = argv[i + 1]; + i++; + } + } + else if (PARAMETER_CHECK("-s", 2, parameterLength)) { + sameStrand = true; + } + else if (PARAMETER_CHECK("-S", 2, parameterLength)) { + diffStrand = true; + } + else if (PARAMETER_CHECK("-d", 2, parameterLength)) { + reportDistance = true; + } + else if (PARAMETER_CHECK("-D", 2, parameterLength)) { + if ((i+1) < argc) { + reportDistance = true; + signDistance = true; + haveStrandedDistMode = true; + strandedDistMode = argv[i + 1]; + i++; + } + } + else if (PARAMETER_CHECK("-io", 3, parameterLength)) { + ignoreOverlaps = true; + } + else if (PARAMETER_CHECK("-t", 2, parameterLength)) { + if ((i+1) < argc) { + haveTieMode = true; + tieMode = argv[i + 1]; + i++; + } + } + else { + cerr << endl << "*****ERROR: Unrecognized parameter: " << argv[i] << " *****" << endl << endl; + showHelp = true; + } + } + + // make sure we have both input files + if (!haveBedA || !haveBedB) { + cerr << endl << "*****" << endl << "*****ERROR: Need -a and -b files. " << endl << "*****" << endl; + showHelp = true; + } + + if (haveTieMode && (tieMode != "all") && (tieMode != "first") + && (tieMode != "last")) { + cerr << endl << "*****" << endl << "*****ERROR: Request \"all\" or \"first\" or \"last\" for Tie Mode (-t)" << endl << "*****" << endl; + showHelp = true; + } + + if (haveStrandedDistMode && (strandedDistMode != "a") && (strandedDistMode != "b") + && (strandedDistMode != "ref")) { + cerr << endl << "*****" << endl << "*****ERROR: Request \"a\" or \"b\" or \"ref\" for Stranded Distance Mode (-D)" << endl << "*****" << endl; + showHelp = true; + } + + if (sameStrand && diffStrand) { + cerr << endl << "*****" << endl << "*****ERROR: Request either -s OR -S, not both." << endl << "*****" << endl; + showHelp = true; + } + + if (!showHelp) { + BedClosest *bc = new BedClosest(bedAFile, bedBFile, sameStrand, diffStrand, tieMode, reportDistance, signDistance, strandedDistMode, ignoreOverlaps); + delete bc; + return 0; + } + else { + ShowHelp(); + } +} + +void ShowHelp(void) { + + cerr << endl << "Program: " << PROGRAM_NAME << " (v" << VERSION << ")" << endl; + + cerr << "Authors: Aaron Quinlan (aaronquinlan@gmail.com)" << endl; + cerr << "\t Erik Arner, Riken" << endl << endl; + + cerr << "Summary: For each feature in A, finds the closest " << endl; + cerr << "\t feature (upstream or downstream) in B." << endl << endl; + + cerr << "Usage: " << PROGRAM_NAME << " [OPTIONS] -a <bed/gff/vcf> -b <bed/gff/vcf>" << endl << endl; + + cerr << "Options: " << endl; + cerr << "\t-s\t" << "Require same strandedness. That is, find the closest feature in B" << endl; + cerr << "\t\tthat overlaps A on the _same_ strand." << endl; + cerr << "\t\t- By default, overlaps are reported without respect to strand." << endl << endl; + + cerr << "\t-S\t" << "Require opposite strandedness. That is, find the closest feature in B" << endl; + cerr << "\t\tthat overlaps A on the _opposite_ strand." << endl; + cerr << "\t\t- By default, overlaps are reported without respect to strand." << endl << endl; + + cerr << "\t-d\t" << "In addition to the closest feature in B, " << endl; + cerr << "\t\treport its distance to A as an extra column." << endl; + cerr << "\t\t- The reported distance for overlapping features will be 0." << endl << endl; + + cerr << "\t-D\t" << "Like -d, report the closest feature in B, and its distance to A" << endl; + cerr << "\t\tas an extra column. Unlike -d, use negative distances to report" << endl; + cerr << "\t\tupstream features. You must specify which orientation defines \"upstream\"." << endl; + cerr << "\t\tThe options are:" << endl; + cerr << "\t\t- \"ref\" Report distance with respect to the reference genome. " << endl; + cerr << "\t\t B features with a lower (start, stop) are upstream" << endl; + cerr << "\t\t- \"a\" Report distance with respect to A." << endl; + cerr << "\t\t When A is on the - strand, \"upstream\" means B has a higher (start,stop)." << endl; + cerr << "\t\t- \"b\" Report distance with respect to B." << endl; + cerr << "\t\t When B is on the - strand, \"upstream\" means A has a higher (start,stop)." << endl << endl; + + cerr << "\t-io\t" << "Ignore features in B that overlap A. That is, we want close, but " << endl; + cerr << "\t\tnot touching features only." << endl << endl; + + cerr << "\t-t\t" << "How ties for closest feature are handled. This occurs when two" << endl; + cerr << "\t\tfeatures in B have exactly the same \"closeness\" with A." << endl; + cerr << "\t\tBy default, all such features in B are reported." << endl; + cerr << "\t\tHere are all the options:" << endl; + cerr << "\t\t- \"all\" Report all ties (default)." << endl; + cerr << "\t\t- \"first\" Report the first tie that occurred in the B file." << endl; + cerr << "\t\t- \"last\" Report the last tie that occurred in the B file." << endl << endl; + + cerr << "Notes: " << endl; + cerr << "\tReports \"none\" for chrom and \"-1\" for all other fields when a feature" << endl; + cerr << "\tis not found in B on the same chromosome as the feature in A." << endl; + cerr << "\tE.g. none\t-1\t-1" << endl << endl; + + // end the program here + exit(1); +}